Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01385)
Name
Revefenacin
Synonyms    Click to Show/Hide the Synonyms of This API
Revefenacin; 864750-70-9; TD-4208; Yupelri; GSK-1160724; UNII-G2AE2VE07O; GSK1160724; G2AE2VE07O; 864750-70-9 (free base); [1-[2-[[4-[(4-carbamoylpiperidin-1-yl)methyl]benzoyl]-methylamino]ethyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate; 1-(2-(4-((4-Carbamoylpiperidin-1-yl)methyl)-N-methylbenzamido)ethyl)piperidin-4-yl N-((1,1'-biphenyl)-2-yl)carbamate; TD-4208; GSK-1160724;[1-[2-[[4-[(4-carbamoylpiperidin-1-yl)methyl]benzoyl]-methylamino]ethyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate; Revefenacin [INN]; Revefenacin [WHO-DD]; Revefenacin (USAN/INN); Revefenacin [USAN:INN]; Revefenacin;GSK1160724; SCHEMBL356480; CHEMBL3833319; GTPL10129; HMS3886K17; AMY16789; BCP15793; EX-A1722; s5258; TD4208; CCG-270187; CS-7743; DB11855; SB17262; BS-18189; HY-15851; Revefenacin; TD-4208; GSK-1160724; D10978; Q27278649; Revefenacin; TD 4208; TD4208; GSK-1160724; GSK1160724; GSK 1160724; Biphenyl-2-ylcarbamic acid, 1-(2-((4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl)methylamino)ethyl)piperidin-4-yl ester; Carbamic acid, N-(1,1'-biphenyl)-2-yl-, 1-(2-((4-((4-(aminocarbonyl)-1-piperidinyl)methyl)benzoyl)methylamino)ethyl)-4-piperidinyl ester
Clinical Status
Approved
PubChem CID
11753673
Formula
C35H43N5O4
Canonical SMILES
CN(CCN1CCC(CC1)OC(=O)NC2=CC=CC=C2C3=CC=CC=C3)C(=O)C4=CC=C(C=C4)CN5CCC(CC5)C(=O)N
InChI
1S/C35H43N5O4/c1-38(34(42)29-13-11-26(12-14-29)25-40-19-15-28(16-20-40)33(36)41)23-24-39-21-17-30(18-22-39)44-35(43)37-32-10-6-5-9-31(32)27-7-3-2-4-8-27/h2-14,28,30H,15-25H2,1H3,(H2,36,41)(H,37,43)
InChIKey
FYDWDCIFZSGNBU-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=11753673"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 597.7 Topological Polar Surface Area 108
XlogP 4.1 Complexity 918
Heavy Atom Count 44 Rotatable Bond Count 11
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 6
Full List of Drug Formulations (DFMs) Containing This API
          Revefenacin 175 mcg/3 ml solution Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium Chloride; Citric Acid; Sodium Citrate; Water For Injection
                   Dosage Form Solution
                   Company Mylan Specialty L.P.
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium citrate anhydrous DIG Info Carbonic anhydrase IV (Ki = 99 nM) [1]
Kyselina citronova DIG Info Perilipin-1 (IC50 = 3708 nM) [2]
References
1 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):573-8.
2 PubChem BioAssay data set.

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