Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01507)
Name
Tromethamine
Synonyms    Click to Show/Hide the Synonyms of This API
Trometamol; TROMETHAMINE; 77-86-1; Tris; Tris(Hydroxymethyl)aminomethane; Tham; 2-Amino-2-(hydroxymethyl)propane-1,3-diol; Trisamine; 2-Amino-2-(hydroxymethyl)-1,3-propanediol; Trizma; Tris buffer; Tris base; Tromethane; Trisaminol; 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-; Pehanorm; Talatrol; Trisamin; Trispuffer; Tutofusin tris; Apiroserum Tham; Tris-steril; Addex-tham; Tris-base; Tris, free base; Trimethylolaminomethane; Tris Amino; Aminotrimethylolmethane; Aminotris(hydroxymethyl)methane; THAM-E; Tris (buffering agent); Tromethanmin; Tris(hydroxymethyl)methanamine; Tris(hydroxymethyl)methylamine; Trometamole; Trizma base; 2-Amino-2-methylol-1,3-propanediol; Tris-hydroxymethylaminomethane; Tri(hydroxymethyl)aminomethane; 2-Amino-2-hydroxymethyl-1,3-propanediol; Tris-Amino; Methylamine, 1,1,1-tris(hydroxymethyl)-; NSC 6365; 2-(Hydroxymethyl)-2-amino-1,3-propanediol; UNII-023C2WHX2V; Tris-hydroxymethyl-aminomethan; Methanamine, 1,1,1-tris(hydroxymethyl)-; MFCD00004679; 023C2WHX2V; CHEBI:9754; tris(hydroxymethyl) aminomethane; Tris(Hydroxymethyl)-Aminomethane; Tris-(hydroxymethyl)-aminomethane; NSC6365; NSC-6365; 1,1,1-tris(hydroxymethyl)methanamine; TRIS (tromethamine); NCGC00159412-02; NCGC00159412-04; Tris buffertris-hydroxymethyl-aminomethan; Tromethamolum; DSSTox_CID_3723; trishydroxymethylaminomethane; WLN: Q1XZ1Q1Q; DSSTox_RID_77165; DSSTox_GSID_23723; (tris(hydroxymethyl)aminomethane); [tris(hydroxymethyl)aminomethane]; Caswell No. 036; Trometamolum; 1, 2-amino-2-(hydroxymethyl)-; Triladyl; Trigmo base; MFCD00132476; Methanamine,1,1-tris(hydroxymethyl)-; Methylamine,1,1-tris(hydroxymethyl)-; Trometamolum [INN-Latin]; tris(hydroxymethyl)amino methane; CAS-77-86-1; Tris(hydroxymethyl)aminomethane, >=99.8%; 2-amino-2-(hydroxymethyl)-1, 3-propanediol; HSDB 3408; EINECS 201-064-4; Tris(hydroxymethyl)aminomethane, Electrophoresis Grade; Tris-Mg(II)-KCl Buffer; Tromethamine [USAN:USP]; EPA Pesticide Chemical Code 083901; Tris(hydroxymethyl)aminomethane, 99+%, for biochemistry; Tris-hydroxymethyl-aminomethan [German]; Trometamina; Tromethamin; Aminotri(hydroxymethyl)methane; Tribase; tris-buffer; tris-amine; AI3-03948; Tro.meta.mole; Tris(hydroxymethyl)aminomethane, 99.8%, for analysis, biochemical grade; Tro.meta.mol; Tris(hydroxymethyly)amino methane; 1gng; 83147-39-1; Tris(hydroxymethyl)aminomethane, 99.85%, for molecular biology, DNAse, RNAse and Protease free; Trometamol [INN]; TRS; Tromethamine (USP); TRIS Ultrapure, EP; 1h4n; Trometamol (JAN/INN); Tris-[d11]; Tris-Magnesium(II)-Potassium Chloride Buffer; SCHEMBL975; trishydroxymethylmethylamine; THAM (TN); Buffer Salt, pH 10.5; EC 201-064-4; Tri(hydroxymethyl)methylamin; NCIOpen2_000263; NCIOpen2_001720; 2-Amino-2-hydroxymethyl-1,3-propanediol solution; Oprea1_677781; trishydroxymethyl aminomethane; tris-hydroxymethyl-methylamine; B-TRIS500; MLS000028643; ARONIS23912; tris hydroxymethyl aminomethane; Tris (hydroxymethyl)aminoethane; GTPL7328; tris (hydroxymethyl)aminomethane; CHEMBL1200391; DTXSID2023723; tris (hydroxymethyl) methylamine; tris (hydroxymethyl) aminomethane; Tris(2-hydroxymethyl)aminomethane; 2-Amino-2-hydroxymethylpropanediol; HMS3652L05; HMS3885H09; tris-(hydroxymethyl)-amino-methane; ZINC896695; 2-amino-2-hydroxymethyl-propane-1; Tris-Base, molecular biology grade; BCP05578; HY-D0227; NSC65434; STR03166; Tox21_111645; Tox21_201646; Tox21_303167; BBL000011; NSC-65434; s4176; SBB006714; STK379529; 2-amino-2-methylol-propane-1,3-diol; AKOS000121321; Tox21_111645_1; AM90366; CCG-214012; CS-W018524; DB03754; MCULE-7300085951; NE10342; Trizma(R) base, >=99.0% (T); ATX Tris buffer, ready-to-use solution; Tris(hydroxymethyl)aminomethane, >=99%; NCGC00159412-03; NCGC00159412-05; NCGC00257164-01; NCGC00259195-01; TRIS, 0.5M buffer solution, pH 6.8; TRIS, 0.5M buffer solution, pH 7.2; TRIS, 0.5M buffer solution, pH 7.4; TRIS, 0.5M buffer solution, pH 7.5; TRIS, 0.5M buffer solution, pH 8.0; TRIS, 0.5M buffer solution, pH 8.5; TRIS, 0.5M buffer solution, pH 8.6; TRIS, 0.5M buffer solution, pH 8.8; TRIS, 0.5M buffer solution, pH 9.0; TRIS, 0.5M buffer solution, pH 9.5; TRIS, 1.0M buffer solution, pH 6.5; TRIS, 1.0M buffer solution, pH 7.4; TRIS, 1.0M buffer solution, pH 7.6; TRIS, 1.0M buffer solution, pH 7.8; TRIS, 1.0M buffer solution, pH 8.2; TRIS, 1.0M buffer solution, pH 8.4; TRIS, 1.0M buffer solution, pH 8.6; TRIS, 1.0M buffer solution, pH 8.8; TRIS, 1.0M buffer solution, pH 9.0; AK-41163; BP-13394; SMR000059179; Tris(hydroxymethyl)aminomethane ACS grade; Tris(hydroxymethyl)aminomethane, ultrapure; 2-amino-2-[hydroxymethyl]-1,3-propandiol; DB-091324; DS-014869; Methanamine, 1, 1,1-tris(hydroxymethyl)-; Tris acidimetric, NIST(R) SRM(R) 723e; A0321; FT-0611014; ST51037436; SW219208-1; T6977; TRIS-buffered saline (TBS, 10X) pH 7.4; TRIS-buffered saline (TBS, 10X) pH 7.6; TRIS-buffered saline (TBS, 10X) pH 8.0; TRIS-buffered saline (TBS, 20X) pH 7.4; 2-(Hydroxymethyl)-2-amino-1, 3-propanediol; 2-amino-2-(hydroxyl-methyl)propane-1,3-diol; 2-amino-2-(hydroxymethyl) propane-1,3-diol; 2-Amino-2-(hydroxymethyl)-1,3-propanediol;; Tris-amino, Tromethane, Trometamol, Trisamine; Trizma(R) base, BioUltra, >=99.8% (T); Trizma(R) base, tested according to Ph.Eur.; Tromethamine, meets USP testing specifications; 1606-EP1441224A2; 1606-EP2269977A2; 1606-EP2269992A1; 1606-EP2270000A1; 1606-EP2270001A1; 1606-EP2270004A1; 1606-EP2270014A1; 1606-EP2270101A1; 1606-EP2270895A2; 1606-EP2272516A2; 1606-EP2272817A1; 1606-EP2272825A2; 1606-EP2272827A1; 1606-EP2272835A1; 1606-EP2272844A1; 1606-EP2272972A1; 1606-EP2272973A1; 1606-EP2275105A1; 1606-EP2275413A1; 1606-EP2275420A1; 1606-EP2275469A1; 1606-EP2277507A1; 1606-EP2277872A1; 1606-EP2277877A1; 1606-EP2277881A1; 1606-EP2277882A1; 1606-EP2278637A1; 1606-EP2280004A1; 1606-EP2280005A1; 1606-EP2280006A1; 1606-EP2280011A1; 1606-EP2280012A2; 1606-EP2280020A1; 1606-EP2280021A1; 1606-EP2281813A1; 1606-EP2281818A1; 1606-EP2281899A2; 1606-EP2284157A1; 1606-EP2284169A1; 1606-EP2286795A1; 1606-EP2287156A1; 1606-EP2287161A1; 1606-EP2287162A1; 1606-EP2287165A2; 1606-EP2287166A2; 1606-EP2289868A1; 1606-EP2289883A1; 1606-EP2289884A1; 1606-EP2289886A1; 1606-EP2289890A1; 1606-EP2289891A2; 1606-EP2289894A2; 1606-EP2292589A1; 1606-EP2292593A2; 1606-EP2292596A2; 1606-EP2292607A2; 1606-EP2292610A1; 1606-EP2292620A2; 1606-EP2295055A2; 1606-EP2295406A1; 1606-EP2295410A1; 1606-EP2295417A1; 1606-EP2295421A1; 1606-EP2295423A1; 1606-EP2295424A1; 1606-EP2295429A1; 1606-EP2295434A2; 1606-EP2295436A1; 1606-EP2295439A1; 1606-EP2295550A2; 1606-EP2298305A1; 1606-EP2298312A1; 1606-EP2298728A1; 1606-EP2298744A2; 1606-EP2298769A1; 1606-EP2298773A1; 1606-EP2298774A1; 1606-EP2298783A1; 1606-EP2299785A1; 1606-EP2301921A1; 1606-EP2301926A1; 1606-EP2301928A1; 1606-EP2301930A1; 1606-EP2301932A1; 1606-EP2301934A1; 1606-EP2301937A1; 1606-EP2301939A1; 1606-EP2302382A2; 1606-EP2302383A2; 1606-EP2305250A1; 1606-EP2305641A1; 1606-EP2305672A1; 1606-EP2305677A1; 1606-EP2305687A1; 1606-EP2305825A1; 1606-EP2306788A1; 1606-EP2306789A1; 1606-EP2308841A2; 1606-EP2308851A1; 1606-EP2308855A1; 1606-EP2308866A1; 1606-EP2308873A1; 1606-EP2308874A1; 1606-EP2308878A2; 1606-EP2311453A1; 1606-EP2311801A1; 1606-EP2311802A1; 1606-EP2311803A1; 1606-EP2311807A1; 1606-EP2311814A1; 1606-EP2311818A1; 1606-EP2314571A2; 1606-EP2314584A1; 1606-EP2314585A1; 1606-EP2316824A1; 1606-EP2316830A2; 1606-EP2316832A1; 1606-EP2316833A1; 1606-EP2371811A2; 1606-EP2371814A1; 1606-EP2374784A1; 1606-EP2374785A1; 3368-EP2269610A2; 3368-EP2270002A1; 3368-EP2270010A1; 3368-EP2272517A1; 3368-EP2272822A1; 3368-EP2277848A1; 3368-EP2281815A1; 3368-EP2284160A1; 3368-EP2284172A1; 3368-EP2289510A1; 3368-EP2289890A1; 3368-EP2295406A1; 3368-EP2295409A1; 3368-EP2301933A1; 3368-EP2301937A1; 3368-EP2305250A1; 3368-EP2305640A2; 3368-EP2305646A1; 3368-EP2305677A1; 3368-EP2305679A1; 3368-EP2305682A1; 3368-EP2308840A1; 3368-EP2308879A1; 3368-EP2311827A1; 3368-EP2311842A2; 3368-EP2314295A1; 3368-EP2314574A1; 3368-EP2314588A1; 3368-EP2314590A1; 3368-EP2316457A1; 3368-EP2316458A1; 3368-EP2316825A1; 3368-EP2316826A1; 3368-EP2316827A1; 3368-EP2316828A1; C07182; D00396; M02623; 23153-EP2270505A1; 23153-EP2272832A1; 23153-EP2281899A2; 23153-EP2284159A1; 23153-EP2287163A1; 23153-EP2289883A1; 23153-EP2292592A1; 23153-EP2295407A1; 23153-EP2298736A1; 23153-EP2298743A1; 23153-EP2298767A1; 23153-EP2298778A1; 23153-EP2305641A1; 23153-EP2305651A1; 23153-EP2305678A1; 23153-EP2305684A1; 23153-EP2308510A1; 23153-EP2308854A1; 23153-EP2314584A1; 23153-EP2314587A1; 27256-EP2272822A1; 27256-EP2314575A1; 42340-EP2305808A1; 42340-EP2308479A2; 42340-EP2311808A1; 42340-EP2311829A1; AB00443859_03; AB00443859_04; 111860-EP2292611A1; 111860-EP2298761A1; 116174-EP2289891A2; 116174-EP2298770A1; Q413961; Sigma 7-9(R), >=99% (titration), crystalline; SR-01000944234; Trizma(R) base, puriss. p.a., >=99.7% (T); J-610076; SR-01000944234-1; Trizma(R) base, >=99.9% (titration), crystalline; Trizma(R) base, Vetec(TM) reagent grade, >=99%; W-104296; Tris(hydroxymethyl)aminomethane, 99.8%, ACS reagent; Tris(hydroxymethyl)aminomethane, ACS reagent, 99.9%; TRIS-buffered saline (TBS, 10X, low salt) pH 8.0; 4-Anilino-1-(2-hydroxyethylamino)anthracene-9,11-dione; F0001-1979; Tris(hydroxymethyl)aminomethane, ACS reagent, >=99.8%; Tris(hydroxymethyl)aminomethane, Molecular Biology Grade; TRIS-buffered saline (TBS, 10X, high salt) pH 7.4; Z1317839150; Tris(hydroxymethyl)aminomethane, p.a., ACS reagent, 99.8%; Tris(hydroxymethyl)aminomethane, ultrapure grade, >=99.9%; TRIS-buffered saline (TBS, 10X), with 1% Triton X-100; Trizma(R) base, puriss. p.a., buffer substance, >=99.5%; Trometamol, European Pharmacopoeia (EP) Reference Standard; Tris(hydroxymethyl)aminomethane, JIS special grade, >=99.0%; TRIS, 1.0M buffer solution, pH 7.0, 0.2 micron filtered; TRIS, 1.0M buffer solution, pH 8.5, 0.2 micron filtered; TRIS, 1.0M buffer solution, pH 9.0, 0.2 micron filtered; TRIS-buffered saline (TBS, 10X) pH 7.4, for Western blot; Trizma(R) base, anhydrous, free-flowing, Redi-Dri(TM), >=99.9%; Trizma(R) base, BioUltra, for molecular biology, >=99.8% (T); Tromethamine, United States Pharmacopeia (USP) Reference Standard; Trizma(R) base, cell culture tested, >=99.9% (titration), crystalline; Trizma(R) base, BioXtra, pH 10.5-12.0 (1 M in H2O), >=99.9% (titration); Trizma(R) base, Primary Standard and Buffer, >=99.9% (titration), crystalline; Tromethamine, Pharmaceutical Secondary Standard; Certified Reference Materi
Clinical Status
Approved
PubChem CID
6503
Formula
C4H11NO3
Canonical SMILES
C(C(CO)(CO)N)O
InChI
1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2
InChIKey
LENZDBCJOHFCAS-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
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3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 121.14 Topological Polar Surface Area 86.7
XlogP -2.9 Complexity 54
Heavy Atom Count 8 Rotatable Bond Count 3
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 4
Full List of Drug Formulations (DFMs) Containing This API
          Tromethamine 10mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Hydroxypropyl Cellulose; Hypromellose, Unspecified; Lactose Monohydrate; Magnesium Stearate; Microcrystalline Cellulose; Polyethylene Glycol, Unspecified; Titanium Dioxide
                   Dosage Form Tablet
                   Company Proficient Rx
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Hydroxypropyl cellulose DIG Info Mephenytoin 4-hydroxylase (EC50 = 89.5 uM) [1]
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [1]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Polyethylene glycol 4000 DIG Info Albendazole monooxygenase (Inhibition ratio < 40 %) [3]
          Tromethamine 30mg/ml powder Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Alcohol; Hydrochloric Acid; Sodium Chloride; Sodium Hydroxide
                   Dosage Form Powder
                   Company Fosun Pharma Usa
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Hydrochloric acid DIG Info Carbonic anhydrase V (Ki = 156 nM) [4]
          Tromethamine 60mg/2ml powder Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Alcohol; Hydrochloric Acid; Sodium Chloride; Sodium Hydroxide
                   Dosage Form Powder
                   Company Fosun Pharma Usa
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Hydrochloric acid DIG Info Carbonic anhydrase V (Ki = 156 nM) [4]
          Tromethamine 15.75mg spray Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Edetate Disodium; Potassium Phosphate, Monobasic; Sodium Hydroxide; Water
                   Dosage Form Spray
                   Company Zyla Life Sciences Us
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Potassium phosphate monobasic DIG Info Intestinal alkaline phosphatase (IC50 = 2410 nM) [5]
References
1 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
3 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
4 Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1; 14(21):5435-9.
5 Synthesis, crystal structure and biological evaluation of some novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines. Eur J Med Chem. 2014 May 6; 78:167-77.

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