Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0J4OX)
DIG Name	Hydroxypropyl cellulose
DIG Function	Binding agent; Coating agent; Emulsifying agent; Film/Membrane-forming agent; Modified-release agent; Suspending agent; Viscosity-controlling agent

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 01		Infectious/parasitic disease	Click to Show/Hide
Metronidazole	API Info	Amebiasis [ICD-11: 1A36]		[1]
Raltegravir	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[2]
ICD Disease Classification 02		Benign/in-situ/malignant neoplasm	Click to Show/Hide
Enasidenib	API Info	Acute myeloid leukemia [ICD-11: 2A60]		[3]
Osimertinib	API Info	Lung cancer [ICD-11: 2C25]		[4]
Alectinib	API Info	Lung cancer [ICD-11: 2C25]		[5]
Cabozantinib	API Info	Thyroid cancer [ICD-11: 2D10]		[6]
ICD Disease Classification 03		Blood/blood-forming organ disease	Click to Show/Hide
Ruxolitinib	API Info	Thrombocytosis [ICD-11: 3B63]		[7]
ICD Disease Classification 04		Immune system disease	Click to Show/Hide
Cetirizine	API Info	Allergy [ICD-11: 4A80]		[8]
ICD Disease Classification 05		Endocrine/nutritional/metabolic disease	Click to Show/Hide
Atorvastatin	API Info	Hyperlipidaemia [ICD-11: 5C8Z]		[9]
Fluvastatin	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[10]
Alogliptin	API Info	Diabetes mellitus [ICD-11: 5A10]		[11]
Lorcaserin	API Info	Obesity [ICD-11: 5B81]		[12]
Pitavastatin	API Info	Hyperlipidaemia [ICD-11: 5C8Z]		[13]
ICD Disease Classification 06		Mental/behavioural/neurodevelopmental disorder	Click to Show/Hide
Bupropion	API Info	Nicotine dependence [ICD-11: 6C4A]		[14]
Sertraline	API Info	Major depressive disorder [ICD-11: 6A70]		[15]
Cyclobenzaprine	API Info	Major depressive disorder [ICD-11: 6A70]		[16]
Imipramine	API Info	Major depressive disorder [ICD-11: 6A70]		[17]
Fluphenazine	API Info	Schizophrenia [ICD-11: 6A20]		[18]
Trifluoperazine	API Info	Schizophrenia [ICD-11: 6A20]		[19]
Vortioxetine	API Info	Major depressive disorder [ICD-11: 6A70]		[20]
Thioridazine	API Info	Schizophrenia [ICD-11: 6A20]		[21]
Naltrexone	API Info	Alcohol dependence [ICD-11: 6C40]		[22]
ICD Disease Classification 08		Nervous system disease	Click to Show/Hide
Galantamine	API Info	Alzheimer disease [ICD-11: 8A20]		[23]
Donepezil	API Info	Alzheimer disease [ICD-11: 8A20]		[24]
Tiagabine	API Info	Epilepsy [ICD-11: 8A60]		[25]
ICD Disease Classification 11		Circulatory system disease	Click to Show/Hide
Warfarin	API Info	Atrial fibrillation [ICD-11: BC81]		[26]
Clonidine	API Info	Essential hypertension [ICD-11: BA00]		[27]
Losartan	API Info	Essential hypertension [ICD-11: BA00]		[28]
Clopidogrel	API Info	Deep vein thrombosis [ICD-11: BD71]		[29]
Prasugrel	API Info	Myocardial infarction [ICD-11: BA41]		[30]
Quinapril	API Info	Essential hypertension [ICD-11: BA00]		[31]
Dabigatran etexilate	API Info	Venous thromboembolism [ICD-11: BD72]		[32]
Moexipril	API Info	Essential hypertension [ICD-11: BA00]		[33]
ICD Disease Classification 12		Respiratory system disease	Click to Show/Hide
Budesonide	API Info	Allergic rhinitis [ICD-11: CA08]		[34]
Cefpodoxime	API Info	Bronchitis [ICD-11: CA20]		[35]
ICD Disease Classification 13		Digestive system disease	Click to Show/Hide
Pantoprazole	API Info	Gastro-oesophageal reflux disease [ICD-11: DA22]		[36]
Famotidine	API Info	Peptic ulcer [ICD-11: DA61]		[37]
ICD Disease Classification 14		Skin disease	Click to Show/Hide
Pseudoephedrine	API Info	Erythema multiforme [ICD-11: EB12]		[38]
ICD Disease Classification 15		Musculoskeletal/connective-tissue disease	Click to Show/Hide
Raloxifene	API Info	Osteoporosis [ICD-11: FB83]		[39]
Tofacitinib	API Info	Rheumatoid arthritis [ICD-11: FA20]		[40]

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
Oxidoreductase (ORase)
DBT Name: Mephenytoin 4-hydroxylase (CYP2C19)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	EC50 = 89.5 uM (tested by experiment)		[41]
Tested Species	Homo sapiens (Human)
UniProt ID	CP2CJ_HUMAN
DBT Name: Debrisoquine 4-hydroxylase (CYP2D6)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	EC50 = 148.3 uM (tested by experiment)		[41]
Tested Species	Homo sapiens (Human)
UniProt ID	CP2D6_HUMAN
Lyase/isomerase/ligase (L/I/G)
DBT Name: Cholesterol 25-hydroxylase (CYP1A2)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	EC50 = 139 uM (tested by experiment)		[41]
Tested Species	Homo sapiens (Human)
UniProt ID	CP1A2_HUMAN

References
1	FDA label for approved metronidazole from the official website of the U.S. Food and Drug Administration.
2	2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.
3	FDA label for approved enasidenib from the official website of the U.S. Food and Drug Administration.
4	FDA label for approved osimertinib from the official website of the U.S. Food and Drug Administration.
5	FDA label for approved alectinib from the official website of the U.S. Food and Drug Administration.
6	FDA label for approved cabozantinib from the official website of the U.S. Food and Drug Administration.
7	FDA label for approved ruxolitinib from the official website of the U.S. Food and Drug Administration.
8	FDA label for approved cetirizine from the official website of the U.S. Food and Drug Administration.
9	FDA label for approved atorvastatin from the official website of the U.S. Food and Drug Administration.
10	FDA label for approved fluvastatin from the official website of the U.S. Food and Drug Administration.
11	FDA label for approved alogliptin from the official website of the U.S. Food and Drug Administration.
12	FDA label for approved lorcaserin from the official website of the U.S. Food and Drug Administration.
13	FDA label for approved pitavastatin from the official website of the U.S. Food and Drug Administration.
14	FDA label for approved bupropion from the official website of the U.S. Food and Drug Administration.
15	FDA label for approved sertraline from the official website of the U.S. Food and Drug Administration.
16	FDA label for approved cyclobenzaprine from the official website of the U.S. Food and Drug Administration.
17	FDA label for approved imipramine from the official website of the U.S. Food and Drug Administration.
18	FDA label for approved fluphenazine from the official website of the U.S. Food and Drug Administration.
19	FDA label for approved trifluoperazine from the official website of the U.S. Food and Drug Administration.
20	FDA label for approved vortioxetine from the official website of the U.S. Food and Drug Administration.
21	FDA label for approved thioridazine from the official website of the U.S. Food and Drug Administration.
22	FDA label for approved naltrexone from the official website of the U.S. Food and Drug Administration.
23	FDA label for approved galantamine from the official website of the U.S. Food and Drug Administration.
24	FDA label for approved donepezil from the official website of the U.S. Food and Drug Administration.
25	FDA label for approved tiagabine from the official website of the U.S. Food and Drug Administration.
26	FDA label for approved warfarin from the official website of the U.S. Food and Drug Administration.
27	FDA label for approved clonidine from the official website of the U.S. Food and Drug Administration.
28	FDA label for approved losartan from the official website of the U.S. Food and Drug Administration.
29	FDA label for approved clopidogrel from the official website of the U.S. Food and Drug Administration.
30	FDA label for approved prasugrel from the official website of the U.S. Food and Drug Administration.
31	FDA label for approved quinapril from the official website of the U.S. Food and Drug Administration.
32	FDA label for approved dabigatran etexilate from the official website of the U.S. Food and Drug Administration.
33	FDA label for approved moexipril from the official website of the U.S. Food and Drug Administration.
34	FDA label for approved budesonide from the official website of the U.S. Food and Drug Administration.
35	FDA label for approved cefpodoxime from the official website of the U.S. Food and Drug Administration.
36	FDA label for approved pantoprazole from the official website of the U.S. Food and Drug Administration.
37	FDA label for approved famotidine from the official website of the U.S. Food and Drug Administration.
38	A study of sustained action pseudoephedrine in allergic rhinitis. Ann Allergy. 1982 Feb;48(2):87-92.
39	FDA label for approved raloxifene from the official website of the U.S. Food and Drug Administration.
40	FDA label for approved tofacitinib from the official website of the U.S. Food and Drug Administration.
41	Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.

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