Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00081)
Name
Bumetanide
Synonyms    Click to Show/Hide the Synonyms of This API
bumetanide; 28395-03-1; 3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid; Burinex; Fordiuran; Lunetoron; Fontego; Segurex; Ro 10-6338; Bumetanida; Bumetanidum; Bumetanidum [INN-Latin]; 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid; Bumetanida [INN-Spanish]; PF 1593; Benzoic acid, 3-(aminosulfonyl)-5-(butylamino)-4-phenoxy-; UNII-0Y2S3XUQ5H; Bumetanide-d5; C17H20N2O5S; 0Y2S3XUQ5H; MLS000028457; CHEBI:3213; Aquazone; Butinat; Cambiex; Diurama; Yurinex; BENZOIC ACID, 3-(BUTYLAMINO)-4-PHENOXY-5-SULFAMOYL-; Burine; 3-butylamino-4-phenoxy-5-sulfamoyl-benzoic acid; 3-butylamino-4-(phenoxy)-5-sulfamoylbenzoic acid; Lixil-Leo; 3-(butylamino)-4-phenoxy-5-sulfamoyl-benzoic acid; MFCD00078949; NCGC00015149-02; SMR000058418; CAS-28395-03-1; Ro 10-6338;PF 1593; DSSTox_CID_2699; 3-butylamino-4-phenoxy-5-sulfamoylbenzoic acid; DSSTox_RID_76695; DSSTox_GSID_22699; Bufenox; Bumex (TN); SR-01000003062; EINECS 249-004-6; BRN 2185351; Bumetanide (Ro 10-6338); Prestwick_679; Bumetanide [USAN:USP:INN:BAN:JAN]; Ro-10-6338; Spectrum_001317; Bumetanide, >=98%; Opera_ID_1734; Prestwick0_000276; Prestwick1_000276; Prestwick2_000276; Prestwick3_000276; Spectrum2_001050; Spectrum3_001481; Spectrum4_000030; Spectrum5_001212; Lopac-B-3023; B 3023; cid_2471; CHEMBL1072; Lopac0_000162; SCHEMBL27525; BSPBio_000152; BSPBio_001508; BSPBio_003061; KBioGR_000228; KBioGR_000439; KBioSS_000228; KBioSS_001797; MLS001148265; DivK1c_000034; SPECTRUM1502004; SPBio_000980; SPBio_002371; BPBio1_000168; Bumetanide (JP17/USP/INN); GTPL4837; DTXSID5022699; BDBM25903; HMS500B16; KBio1_000034; KBio2_000228; KBio2_001797; KBio2_002796; KBio2_004365; KBio2_005364; KBio2_006933; KBio3_000455; KBio3_000456; KBio3_002561; NINDS_000034; 3-(aminosulfonyl)-5-(butylamino)-4-(phenyloxy)benzoic acid; Bio1_000421; Bio1_000910; Bio1_001399; Bio2_000228; Bio2_000708; HMS1361L10; HMS1568H14; HMS1791L10; HMS1921B20; HMS1989L10; HMS2089P13; HMS2092N03; HMS2095H14; HMS2230P15; HMS3259O08; HMS3260B05; HMS3374E02; HMS3402L10; HMS3654B13; HMS3712H14; HMS3873C13; Pharmakon1600-01502004; BCP28485; ZINC3813061; Tox21_110088; Tox21_500162; ANW-45473; CCG-40125; NSC758145; AKOS015896600; Tox21_110088_1; AC-8115; CS-1821; DB00887; KS-5211; LP00162; MCULE-6802013568; NC00550; NE48825; NSC-758145; Ro-106338; SDCCGSBI-0050150.P004; IDI1_000034; IDI1_033978; SMP1_000049; NCGC00015149-01; NCGC00015149-03; NCGC00015149-04; NCGC00015149-05; NCGC00015149-06; NCGC00015149-07; NCGC00015149-08; NCGC00015149-09; NCGC00015149-10; NCGC00015149-11; NCGC00015149-12; NCGC00015149-13; NCGC00015149-15; NCGC00015149-16; NCGC00015149-26; NCGC00022072-03; NCGC00022072-04; NCGC00022072-05; NCGC00022072-06; NCGC00022072-07; NCGC00022072-08; NCGC00260847-01; HY-17468; SBI-0050150.P003; AB0012138; AB00052253; EU-0100162; ST51014910; SW196834-3; D00247; J10080; 3-butylamino-4-phenoxy-5-sulphamyl-benzoic acid; AB00052253-15; AB00052253-16; AB00052253_17; AB00052253_18; 3-n-butylamino-4-phenoxy-5-sulfamyl-benzoic acid; 3-n-butylamino-4-phenoxy-5-sulphamyl-benzoic acid; 395B031; A819434; Q275926; S95008.; J-017055; S-95008.; SR-01000003062-2; SR-01000003062-4; SR-01000003062-7; BRD-K38197229-001-06-7; BRD-K38197229-001-17-4; Z1550648769; Bumetanide, British Pharmacopoeia (BP) Reference Standard; Bumetanide, European Pharmacopoeia (EP) Reference Standard; Bumetanide, United States Pharmacopeia (USP) Reference Standard; Ro 10-6338; PF 1593 pound>>Ro-10-6338; PF1593 pound>>Ro10-6338; PF-1593
Clinical Status
Approved
Disease Indication Congestive heart failure ICD-11: BD10 [1]
PubChem CID
2471
Formula
C17H20N2O5S
Canonical SMILES
CCCCNC1=C(C(=CC(=C1)C(=O)O)S(=O)(=O)N)OC2=CC=CC=C2
InChI
1S/C17H20N2O5S/c1-2-3-9-19-14-10-12(17(20)21)11-15(25(18,22)23)16(14)24-13-7-5-4-6-8-13/h4-8,10-11,19H,2-3,9H2,1H3,(H,20,21)(H2,18,22,23)
InChIKey
MAEIEVLCKWDQJH-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=2471"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 364.4 Topological Polar Surface Area 127
XlogP 2.8 Complexity 528
Heavy Atom Count 25 Rotatable Bond Count 8
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 7
Full List of Drug Formulations (DFMs) Containing This API
          Bumetanide 0.5 mg tablet Click to Show/Hide the Full List of Formulation(s):          4 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Magnesium stearate; Talc; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Eon Labs; Mylan Pharamceuticals; Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; Fd&c blue no. 1; Magnesium stearate; Talc; Aluminum oxide; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company AvKARE; Carilion Materials Management; Lake Eire Medical & Surgical Supply DBA Quality Care Products; Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; Fd&c blue no. 1; Magnesium stearate; Talc; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Edenbridge Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Amneal Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Bumetanide 1 mg tablet Click to Show/Hide the Full List of Formulation(s):          7 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; Magnesium stearate; Talc; Aluminum oxide; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Aidarex Pharmaceuticals; AvKARE; Avera McKennan Hospital; Lake Eire Medical & Surgical Supply DBA Quality Care Products; NCS HealthCare of KY, Inc dba Vangard Labs; NuCare Pharmaceuticals; St Marys Medical Park Pharmacy; Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; Magnesium stearate; Talc; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company NuCare Pharmaceuticals; Paragon Enterprises
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; Magnesium stearate; Talc; Aluminum oxide; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Unit Dose Services
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; Magnesium stearate; Talc; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Edenbridge Pharmaceuticals; Unit Dose Services
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; Magnesium stearate; Talc; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Aphena Pharma Solutions-Tennessee; Avera McKennan Hospital; Cardinal Health; Carilion Materials Management; Eon Labs; Mylan Pharamceuticals; Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; Magnesium stearate; Talc; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Bryant Ranch Prepack; Unit Dose Services
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Amneal Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Bumetanide 2 mg tablet Click to Show/Hide the Full List of Formulation(s):          7 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Talc; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Talc; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Aphena Pharma Solutions-Tennessee; Avera McKennan Hospital; Eon Labs; NuCare Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Talc; Cellulose, microcrystalline; Starch, corn; Starch, corn
                   Dosage Form Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Talc; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Unit Dose Services
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Ferric oxide red; Talc; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company AvKARE; Avera McKennan Hospital; Lake Eire Medical & Surgical Supply DBA Quality Care Products; NCS HealthCare of KY, Inc dba Vangard Labs; St Marys Medical Park Pharmacy; Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Ferric oxide red; Talc; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Bryant Ranch Prepack; Edenbridge Pharmaceuticals; Unit Dose Services
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Amneal Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
References
1 FDA label for approved bumetanide from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
4 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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