Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00123)
Name
Chlorpheniramine
Synonyms    Click to Show/Hide the Synonyms of This API
chlorpheniramine; Chlorphenamine; Teldrin; Chlor-trimeton; Chlorophenylpyridamine; 132-22-9; Clorfeniramina; Phenetron; Haynon; Clorfenamina; Chlorpheniraminum; Kloromin; Polaronil; Chlorphenaminum; Chlorpheniramine polistirex; Antagonate; 3-(4-chlorophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine; 1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane; 3-(p-Chlorophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine; gamma-(4-Chlorophenyl)-gamma-(2-pyridyl)propyldimethylamine; gamma-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine; 1-(p-Chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpropylamine; Chlo-amine; D-Chlorpheniramine; 2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-; CHEMBL505; Chloropheniramine; Chlorprophenpyridamine; Dexchlorpheniramine free base; Allergican; Allergisan; Chloropiril; Cloropiril; Histadur; CHEBI:52010; Chloroprophenpyridamine; 25523-97-1 (free base); Chlorphenamine hydrogen maleate; 2-(p-Chloro-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine; 2-Pyridinepropanamine, .gamma.-(4-chlorophenyl)-N,N-dimethyl-; 3-(4-chlorophenyl)-N,N-dimethyl-3-(2-pyridyl)propan-1-amine; 3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine; Aller-Chlor; Chlorphenamine Maleate; 4-Chloropheniramine; Chloropheniramine maleate; 2-[p-chloro-alpha-[2-(dimethylamino)ethyl]benzyl]pyridine; Chlorphenamin; Telachlor; Chlorprophenpyridamine maleate; Clorfeniramina [Italian]; Clorfenamina [INN-Spanish]; Chlorphenaminum [INN-Latin]; Pyridine, 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-; 1185054-60-7; HSDB 3032; EINECS 205-054-0; Chlorphenamine [INN:BAN]; [3-(4-Chlorophenyl)-3-(2-pyridyl)propyl]dimethylamine; Clofeniramina; PiriIton; Chlor-Pro; [3H]Chlorphenamine; Clofeniramina (TN); [3H]Chlorpheniramine; Chlorphenamine (INN); chlorpheniaramine maleate; S-(+)-Chlorpheniramine; Prestwick0_000117; Prestwick1_000117; Prestwick2_000117; Prestwick3_000117; NCGC00015227-04; 5-HT,N-ACETYL; SCHEMBL4219; Lopac0_000261; Oprea1_779072; BSPBio_000134; DivK1c_000596; Chlorpheniramine Maleate B.P.; SPBio_002073; BPBio1_000148; GTPL6976; DTXSID0022804; BDBM35938; KBio1_000596; Chlorpheniramine-d6see c424303; NINDS_000596; HMS2090M21; HMS3428J07; Chlorpheniramine polistirex [USAN]; BBL012285; SBB017260; STK736174; AKOS001650136; CCG-108982; DB01114; MCULE-2363896855; SB19135; SDCCGSBI-0050249.P002; IDI1_000596; NCGC00015227-03; NCGC00015227-05; NCGC00015227-06; NCGC00015227-09; NCGC00015227-19; NCGC00162108-01; NCGC00162108-02; ST076791; FT-0665002; FT-0772034; C06905; D07398; L000003; Q420133; W-108317; BRD-A04553218-050-03-0; BRD-A04553218-050-08-9; .gamma.-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine; N-[3-(4-Chlorophenyl)-3-(2-pyridinyl)propyl]-N,N-dimethylamine #; n.-Propanamine, 3-(4-chlorophenyl)-3-(2-pyridyl)-N,N-dimethyl-; (?)-3-(4-Chlorophenyl)-N,N-dimethyl-3-(2-pyridinyl)propan-1-amine; 2-Pyridinepropanamine, .gamma.-(4-chlorophenyl)-N,N-dimethyl-, (S)-; Pyridine, 2-[p-chloro-.alpha.-[2-(dimethylamino)ethyl]benzyl]-, (S)-(+)-
Clinical Status
Approved
Disease Indication Allergic rhinitis ICD-11: CA08 [1]
PubChem CID
2725
Formula
C16H19ClN2
Canonical SMILES
CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2
InChI
1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3
InChIKey
SOYKEARSMXGVTM-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=2725"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 274.79 Topological Polar Surface Area 16.1
XlogP 3.4 Complexity 249
Heavy Atom Count 19 Rotatable Bond Count 5
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 2
Full List of Drug Formulations (DFMs) Containing This API
          Chlorpheniramine 12 mg tablet Click to Show/Hide the Full List of Formulation(s):          5 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Methylparaben; Lactose monohydrate; Sodium benzoate; D&c yellow no. 10; Fd&c blue no. 2; Fd&c yellow no. 6; Magnesium stearate; Calcium sulfate; Propylene glycol; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Povidone; Silicon dioxide; Carnauba wax; Cellulose, microcrystalline; Gelatin; Hydroxypropyl cellulose; Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Sodium laureth sulfate
                   Dosage Form 12 HR Extended Release Oral Tablet
                   Company Cardinal Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
methylparaben DIG Info Carbonic anhydrase VII (Ki = 780 nM) [2]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [5]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [6]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [4]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [7]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Methylparaben; Lactose monohydrate; Sodium benzoate; D&c yellow no. 10; Fd&c blue no. 2; Fd&c yellow no. 6; Magnesium stearate; Calcium sulfate; Propylene glycol; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Povidone; Silicon dioxide; Carnauba wax; Cellulose, microcrystalline; Gelatin; Hydroxypropyl cellulose, unspecified; Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Sodium laureth sulfate
                   Dosage Form 12 HR Extended Release Oral Tablet
                   Company GM Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
methylparaben DIG Info Carbonic anhydrase VII (Ki = 780 nM) [2]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [5]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [6]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [4]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [7]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Methylparaben; Lactose monohydrate; Sodium benzoate; D&c yellow no. 10; Fd&c blue no. 2; Fd&c yellow no. 6; Magnesium stearate; Calcium sulfate; Propylene glycol; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Povidone; Silicon dioxide; Carnauba wax; Cellulose, microcrystalline; Gelatin; Low-substituted hydroxypropyl cellulose, unspecified; Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Sodium laureth sulfate
                   Dosage Form 12 HR Extended Release Oral Tablet
                   Company KVK Tech
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
methylparaben DIG Info Carbonic anhydrase VII (Ki = 780 nM) [2]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [5]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [6]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [4]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [7]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Methylparaben; Lactose monohydrate; Sodium benzoate; D&c yellow no. 10; Fd&c blue no. 2; Fd&c yellow no. 6; Magnesium stearate; Calcium sulfate; Propylene glycol; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Silicon dioxide; Carnauba wax; Cellulose, microcrystalline; Gelatin; Low-substituted hydroxypropyl cellulose, unspecified; Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Sodium laureth sulfate
                   Dosage Form 12 HR Extended Release Oral Tablet
                   Company CVS Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
methylparaben DIG Info Carbonic anhydrase VII (Ki = 780 nM) [2]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [5]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [6]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Oleic acid; Lactose monohydrate; Magnesium stearate; Calcium sulfate; Sucrose; Talc; Titanium dioxide; Rosin; Povidone; Acacia; Carnauba wax; Starch, corn; Tribasic calcium phosphate; White wax; Zein
                   Dosage Form 12 HR Extended Release Oral Tablet
                   Company Schering Plough HealthCare Products
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Oleic acid DIG Info Liver lipid-binding protein (Ki = 180 nM) [9]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [7]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
          Chlorpheniramine 4 mg tablet Click to Show/Hide the Full List of Formulation(s):        32 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous lactose; Fd&c red no. 40; Fd&c yellow no. 5; Titanium dioxide; Ethanethiol; Crospovidone; Silicon dioxide; Hypromelloses; Microcrystalline wax; Polyethylene glycols; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company Kareway Product
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [4]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [4]
Hydrazine yellow DIG Info GABA(A) receptor alpha-1 (IC50 = 13 uM) [4]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous lactose; D&c yellow no. 10; Magnesium stearate; Croscarmellose sodium; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Unifirst First Aid
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous lactose; D&c yellow no. 10; Magnesium stearate; Croscarmellose sodium; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Gericare Pharmaceuticals; RemedyRepack; State of Florida DOH Central Pharmacy; Time Cap Labs
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous lactose; D&c yellow no. 10; Magnesium stearate; Croscarmellose sodium; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Chain Drug Marketing Association; Discount Drug Mart; KMART; TopCare
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Magnesium stearate; Anhydrous dibasic calcium phosphate; Croscarmellose sodium; Silicon dioxide; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Advance Pharmaceutical; Richmond Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Magnesium stearate; Anhydrous dibasic calcium phosphate; Croscarmellose sodium; Silicon dioxide; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company SDA Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Magnesium stearate; Anhydrous dibasic calcium phosphate; Croscarmellose sodium; Silicon dioxide; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Contract Pharmacal
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Magnesium stearate; Croscarmellose sodium; Silicon dioxide; Calcium phosphate, dibasic, anhydrous; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Bryant Ranch Prepack; Clinical Solutions Wholesale
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Magnesium stearate; Croscarmellose sodium; Silicon dioxide; Calcium phosphate, dibasic, anhydrous; Cellulose, microcrystalline; Starch, pregelatinized corn
                   Dosage Form Oral Tablet
                   Company Reliable 1 Laboratires; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Magnesium stearate; Croscarmellose sodium; Silicon dioxide; Aluminum oxide; Calcium phosphate, dibasic, anhydrous; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Edwards Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c red no. 40; Magnesium stearate; Povidone k30; Silicon dioxide; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company Fortune Pharmacal
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [4]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose; D&c yellow no. 10; Magnesium stearate; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Contract Pharmacal
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose; D&c yellow no. 10; Magnesium stearate; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Allegiant Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose; D&c yellow no. 10; Magnesium stearate; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Athlete's Needs
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 15 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose; D&c yellow no. 10; Magnesium stearate; Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company Athlete's Needs
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 16 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Fd&c yellow no. 6; Magnesium stearate; Gelatin; Starch, corn
                   Dosage Form Oral Tablet
                   Company Bayer HealthCare
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 17 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; D&c yellow no. 10; Magnesium stearate; Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company Marc Glassman, Inc.
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 18 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; Magnesium stearate; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Cardinal Health; Family Dollar; Rite Aid; Rugby Laboratories; SuperValu; Walgreens Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 19 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; Magnesium stearate; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; Aidarex Pharmaceuticals; DirectRX; Lake Eire Medical & Surgical Supply DBA Quality Care Products
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 20 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; Magnesium stearate; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Better Living Brands; L&R Distributors; Major Pharmaceuticals; Preferred Pharamaceuticals; RemedyRepack; Wal-Mart Stores
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 21 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; Magnesium stearate; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Great Lakes Wholesale Marketing & Sales
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 22 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; Magnesium stearate; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Cardinal Health; UDL Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 23 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; D&c yellow no. 10; Magnesium stearate; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Contract Pharmacal
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 24 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Magnesium stearate
                   Dosage Form Oral Tablet
                   Company Hy-Vee; L. Perrigo Company; McKesson
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 25 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Magnesium stearate
                   Dosage Form Oral Tablet
                   Company American Sales Company; Amerisource Bergen; CVS Pharmacy; Kroger Company; McKesson
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 26 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; Magnesium stearate; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Harmon Stores
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 27 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; Magnesium stearate; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Chain Drug Consortium; McKesson
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 28 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; D&c yellow no. 10; Magnesium stearate; Starch, corn
                   Dosage Form Oral Tablet
                   Company Kroger Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 29 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; Magnesium stearate; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company WinCo Foods
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 30 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Magnesium stearate; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company McKesson
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 31 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Magnesium stearate; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Cardinal Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 32 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate
                   Dosage Form Oral Tablet
                   Company Hy-Vee; L. Perrigo Company; McKesson; SuperValu; Topco Associates
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
References
1 FDA label for approved chlorpheniramine from the official website of the U.S. Food and Drug Administration.
2 Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV. Bioorg Med Chem. 2013 Mar 15; 21(6):1564-9.
3 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
4 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
5 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):573-8.
6 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
7 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
8 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
9 Characterization of the drug binding specificity of rat liver fatty acid binding protein. J Med Chem. 2008 Jul 10; 51(13):3755-64.

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