Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00126)
Name
Chlorthalidone
Synonyms    Click to Show/Hide the Synonyms of This API
chlorthalidone; Chlortalidone; 77-36-1; Phthalamudine; Chlorphthalidolone; Chlorthalidon; Hygroton; Phthalamodine; Chlorothalidone; Thalitone; Chlorphthalidone; Natriuran; Saluretin; Zambesil; Igroton; Isoren; Oradil; Hydro-Long; Oxodolin; Chlortalidonum; Oksodolin (oxodolin); Racemic chlorthalidone; 2-Chloro-5-(1-hydroxy-3-oxoisoindolin-1-yl)benzenesulfonamide; Demi-Regroton; G-33182; 1-Keto-3-(3'-sulfamyl-4'-chlorophenyl)-3-hydroxyisoindoline; 2-Chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)benzenesulfonamide; 3-Hydroxy-3-(4-chloro-3-sulfamylphenyl)phthalimidine; 3-(4'-Chloro-3'-sulfamoylphenyl)-3-hydroxyphthalimidine; 1-Oxo-3-(3-sulfamyl-4-chlorophenyl)-3-hydroxyisoindoline; G 33182; 2-chloro-5-(1-hydroxy-3-oxo-2H-isoindol-1-yl)benzenesulfonamide; NSC-69200; Benzenesulfonamide, 2-chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)-; 2-Chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzenesulfonamide; Benzenesulfonamide, 2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-; MLS000069531; CHEBI:3654; Clortalidone; Famolin; Higroton; Urolin; 2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)benzenesulfonamide; Chlorthalidone, 98%; Clortalidona; SMR000058635; (+-)-Hygroton; Clortalidone [DCIT]; (+-)-Chlorthalidone; DSSTox_CID_2812; 2-chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzene-1-sulfonamide; DSSTox_RID_76738; DSSTox_GSID_22812; Chlortalidonum [INN-Latin]; Clortalidona [INN-Spanish]; C14H11ClN2O4S; Thalitone (TN); Hygroton (TN); Chlorthalidone (USP); HSDB 3035; SR-01000721929; EINECS 201-022-5; NSC 69200; Chlortalidone (JAN/INN); BRN 0312295; Chlorthalidone [USAN:USP]; Oksodolin; CAS-77-36-1; NCGC00016317-01; Prestwick_759; Chlortalidone [INN]; Regroton (Salt/Mix); Combipres (Salt/Mix); Spectrum_000146; Opera_ID_138; (.+/-.)-Hygroton; Prestwick0_000351; Prestwick1_000351; Prestwick2_000351; Prestwick3_000351; Spectrum2_000099; Spectrum3_000349; Spectrum4_000957; Spectrum5_000743; (.+/-.)-Chlorthalidone; CHEMBL1055; SCHEMBL26234; BSPBio_000441; BSPBio_002017; KBioGR_001574; KBioSS_000626; 5-22-07-00602 (Beilstein Handbook Reference); Chlorthalidone (Chlortalidone); DivK1c_000731; SPECTRUM1500187; SPBio_000058; SPBio_002362; BPBio1_000487; GTPL7147; DTXSID4022812; BDBM25900; HMS502E13; KBio1_000731; KBio2_000626; KBio2_003194; KBio2_005762; KBio3_001237; NINDS_000731; HMS1569G03; HMS1920M09; HMS2091E12; HMS2096G03; HMS2236D07; HMS3259H04; HMS3372A07; HMS3713G03; Pharmakon1600-01500187; BCP27835; NSC69200; Tox21_110369; CCG-38917; MFCD00036257; NSC756692; STK686335; Chlortalidone 1.0 mg/ml in Methanol; AKOS005599810; Tox21_110369_1; DB00310; KS-1342; MCULE-6661021422; NC00690; NSC-756692; VZ31574; IDI1_000731; NCGC00094616-01; NCGC00094616-02; NCGC00094616-03; NCGC00094616-04; NCGC00094616-07; AC-11367; AK116459; HY-15833; ST088141; SBI-0051313.P003; AB0007445; DB-056211; [(3,5-Difluorophenyl)amino](oxo)aceticacid; AB00051946; D00272; AB00051946_12; 036C257; Q425289; SR-01000721929-2; SR-01000721929-3; W-104322; BRD-A26384407-001-05-3; BRD-A26384407-001-15-2; 2-chloro-5-(1-hydroxy-3-oxoisoindolinyl)benzenesulfonamide; 2-Chloro-5(1-hydroxy-3-oxo-1-isoindolinyl) benzenesulfonamide; 2-Chloro-5-(1-hydroxy-3-oxo-1H-isoindolinyl)benzenesulfonamide; Chlorthalidone, European Pharmacopoeia (EP) Reference Standard; 2-chloro-5-(1,3-dihydroxy-1H-isoindol-1-yl)benzene-1-sulfonamide; Benzenesulfonamide,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-; Chlorthalidone, United States Pharmacopeia (USP) Reference Standard; 2-chloranyl-5-(1-oxidanyl-3-oxidanylidene-2H-isoindol-1-yl)benzenesulfonamide; 2-Chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzenesulfonamide #; 74658-80-3
Clinical Status
Approved
Disease Indication Huntington disease ICD-11: 8A01 [1]
PubChem CID
2732
Formula
C14H11ClN2O4S
Canonical SMILES
C1=CC=C2C(=C1)C(=O)NC2(C3=CC(=C(C=C3)Cl)S(=O)(=O)N)O
InChI
1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21)
InChIKey
JIVPVXMEBJLZRO-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=2732"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 338.8 Topological Polar Surface Area 118
XlogP 0.9 Complexity 564
Heavy Atom Count 22 Rotatable Bond Count 2
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 5
Full List of Drug Formulations (DFMs) Containing This API
          Chlorthalidone 25 mg tablet Click to Show/Hide the Full List of Formulation(s):          5 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Sodium lauryl sulfate; D&c yellow no. 10; Fd&c yellow no. 6; Magnesium stearate; Croscarmellose sodium; Crospovidone; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company NuCare Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose, unspecified form; Sodium lauryl sulfate; D&c yellow no. 10; Fd&c yellow no. 6; Magnesium stearate; Croscarmellose sodium; Silicon dioxide; Crospovidone (15 mpa.s at 5%); Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company American Health Packaging; Preferred Pharamaceuticals; Sun Pharmaceutical Industries
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Calcium stearate; Fd&c blue no. 1; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a corn; Starch, corn
                   Dosage Form Oral Tablet
                   Company Ingenus Pharmaceuticals; RemedyRepack; RiconPharma; Rising Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; D&c yellow no. 10; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; Bryant Ranch Prepack; Kaiser Foundation Hospitals; Mylan Pharamceuticals; PD-Rx Pharmaceuticals; Physicians Total Care; Rebel Distributors; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; D&c yellow no. 10; Silicon dioxide; Microcrystalline cellulose; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company Bryant Ranch Prepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Chlorthalidone 50 mg tablet Click to Show/Hide the Full List of Formulation(s):          4 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose, unspecified form; Sodium lauryl sulfate; D&c yellow no. 10; Fd&c blue no. 1; Magnesium stearate; Croscarmellose sodium; Silicon dioxide; Cellulose, microcrystalline; Crospovidone (15 mpa.s at 5%)
                   Dosage Form Oral Tablet
                   Company Aphena Pharma Solutions-Tennessee
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose, unspecified form; Sodium lauryl sulfate; D&c yellow no. 10; Fd&c blue no. 1; Magnesium stearate; Croscarmellose sodium; Silicon dioxide; Crospovidone (15 mpa.s at 5%); Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company Sun Pharmaceutical Industries
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; D&c yellow no. 10; Fd&c blue no. 1; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; Aphena Pharma Solutions-Tennessee; Lake Eire Medical & Surgical Supply DBA Quality Care Products; Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Calcium stearate; Fd&c blue no. 1; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a corn; Starch, corn
                   Dosage Form Oral Tablet
                   Company Ingenus Pharmaceuticals; RiconPharma; Rising Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
References
1 FDA label for approved chlorthalidone from the official website of the U.S. Food and Drug Administration.
2 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
3 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
4 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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