Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00182)
Name
Desvenlafaxine
Synonyms    Click to Show/Hide the Synonyms of This API
Desvenlafaxine; 93413-62-8; O-Desmethylvenlafaxine; 4-(2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol; 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol; O-desmethyl venlafaxine; O-Desvenlafaxine; d,l-O-Desmethylvenlafaxine; CHEBI:83527; 93413-62-8 (free base); Desvenlafaxine, 97%; 1-[2-(dimethylamino)-1-(4-hydroxyphenyl)ethyl]cyclohexanol; Phenol, 4-(2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)-; Phenol, 4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]-; Desvenlafaxine [INN:BAN]; Khedezla; Desvenlafaxine (INN); Venlafaxine O-Desmethyl; HSDB 7993; Khedezla (TN); O-DESMETHYLVENLAFAXINE (ODV); O-desmethyl-venlafaxine; ACMC-20ek0k; EC 700-516-2; CHEMBL1118; SCHEMBL34864; MLS006010042; O-Desmethylvenlafaxine solution; (S)-Desmethyl Venlafaxine D6; GTPL7158; 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenol; BDBM86748; DTXSID40869118; HMS3652K16; HMS3885F05; BCP28517; HY-B0602; MFCD00871934; PDSP1_001804; PDSP2_001787; AKOS015896311; CCG-267081; DB06700; DS-1282; SB17444; NSC_6918664; NCGC00345883-04; NCGC00345883-07; AK-72949; AT-19352; BR-72949; SMR004701214; O-Desmethylvenlafaxine, analytical standard; AB0031560; CAS_386750-22-7; FT-0654519; FT-0666245; FT-0666246; SW219514-2; O-Desmethylvenlafaxine 0.1 mg/ml in Methanol; D07793; J10126; S-2830; AB01563022_01; 413D628; A844583; Q2419445; Venlafaxine O-desmethyl 100 microg/mL in Acetonitrile; 4-[2-Dimethyamino-1-(1-hydroxycyclohexyl)ethyl]phenol; 1-[2-dimethylamino-1-(4-hydroxyphenyl)ethyl]cyclohexanol; 4-(2-(Dimethylamino)-1-(1-hydroxycyclohexyl)-ethyl)phenol; 4-[2-(dimethylamino)-1-(1-oxidanylcyclohexyl)ethyl]phenol; 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol #; (RS)-1-[2-(dimethylamino)-1-(4-hydroxyphenyl)ethyl]cyclohexanol; O-Desmethylvenlafaxine solution, 1.0 mg/mL in methanol, certified reference material; O-Desmethylvenlafaxine solution, 100 mug/mL in methanol, ampule of 1 mL, certified reference material
Clinical Status
Approved
Disease Indication Major depressive disorder ICD-11: 6A70 [1]
PubChem CID
125017
Formula
C16H25NO2
Canonical SMILES
CN(C)CC(C1=CC=C(C=C1)O)C2(CCCCC2)O
InChI
1S/C16H25NO2/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16/h6-9,15,18-19H,3-5,10-12H2,1-2H3
InChIKey
KYYIDSXMWOZKMP-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=125017"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 263.37 Topological Polar Surface Area 43.7
XlogP 2.6 Complexity 266
Heavy Atom Count 19 Rotatable Bond Count 4
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Full List of Drug Formulations (DFMs) Containing This API
          Desvenlafaxine 100 mg tablet Click to Show/Hide the Full List of Formulation(s):          5 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c yellow no. 6; Magnesium stearate; Citric acid monohydrate; Ferric oxide red; Ferric oxide yellow; Talc; Titanium dioxide; Polyvinyl alcohol; Silicon dioxide; Cellulose, microcrystalline; Hypromellose 2208 (100000 mpa.s); Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Par Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Polyvinyl alcohol DIG Info Debrisoquine 4-hydroxylase (EC50 = 354.8 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c yellow no. 6; Magnesium stearate; Citric acid monohydrate; Ferric oxide red; Ferric oxide yellow; Talc; Titanium dioxide; Silicon dioxide; Cellulose, microcrystalline; Hypromellose 2208 (100000 mpa.s); Polyethylene glycols; Polyvinyl alcohol, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Macoven Pharmaceuticals; Pernix Therapeutics
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butyl alcohol; Magnesium stearate; Ammonia; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Propylene glycol; Talc; Titanium dioxide; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols; Shellac
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Sun Pharmaceutical Industries
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [5]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Talc; Titanium dioxide; Polyvinyl alcohol; Cellulose, microcrystalline; Hypromellose 2208 (15000 mpa.s); Polyethylene glycol
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Lake Eire Medical & Surgical Supply DBA Quality Care Products
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polyvinyl alcohol DIG Info Debrisoquine 4-hydroxylase (EC50 = 354.8 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Citric acid monohydrate; Ferric oxide red; Ferrosoferric oxide; Talc; Titanium dioxide; Povidone k30; Alginic acid; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycol 8000
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Sun Pharmaceutical Industries
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Desvenlafaxine 50 mg tablet Click to Show/Hide the Full List of Formulation(s):          4 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butyl alcohol; Magnesium stearate; Ammonia; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Propylene glycol; Talc; Titanium dioxide; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols; Shellac
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Sun Pharmaceutical Industries
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [5]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Citric acid monohydrate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Talc; Titanium dioxide; Polyvinyl alcohol; Silicon dioxide; Cellulose, microcrystalline; Hypromellose 2208 (100000 mpa.s); Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Par Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polyvinyl alcohol DIG Info Debrisoquine 4-hydroxylase (EC50 = 354.8 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Citric acid monohydrate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Talc; Titanium dioxide; Silicon dioxide; Cellulose, microcrystalline; Hypromellose 2208 (100000 mpa.s); Polyethylene glycols; Polyvinyl alcohol, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Macoven Pharmaceuticals; Pernix Therapeutics
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Citric acid monohydrate; Ferric oxide red; Talc; Titanium dioxide; Polyethylene glycol 6000; Povidone k30; Alginic acid; Cellulose, microcrystalline; Hypromelloses
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Sun Pharmaceutical Industries
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Polyethylene glycol 6000 DIG Info Albendazole monooxygenase (Inhibition ratio < 70 %) [5]
References
1 FDA label for approved desvenlafaxine from the official website of the U.S. Food and Drug Administration.
2 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
3 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
4 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
5 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.

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