Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00196)
Name
Diethylpropion
Synonyms    Click to Show/Hide the Synonyms of This API
DIETHYLPROPION; Amfepramone; Diethylpropione; Anorex; Tepanil; Frekentine; Danylen; Dobesin; Magrene; Tylinal; 90-84-6; alpha-Benzoyltriethylamine; Amfepramonum; Prefamone; Regenon; alpha-Diethylaminopropiophenone; Anfepramona; 1-Propanone, 2-(diethylamino)-1-phenyl-; Diethylcathinone; Amfepramonum [INN-Latin]; Anfepramona [INN-Spanish]; 2-(Diethylamino)propiophenone; Amfepramone [INN]; 1-Phenyl-2-diethylamino-1-propanone; 2-(Diethylamino)-1-phenyl-1-propanone; 2-(diethylamino)-1-phenylpropan-1-one; Moderatan; Tenuate; Amfepramon; Amfepramone hydrochloride; DEA No. 1610; Propiophenone, 2-(diethylamino)-; Amfepramone (INN); Amphepramon; Amphepramone; Nopropiophenone; Adiposon; Neobes; Tenuate Dospan; Amphepramonum hydrochloride; Diethylpropione hydrochloride; Cegramine; Obesitex; Silutin; Derfon; Regenon hydrochloride; CHEBI:4530; DIETHYLPROPION, DONYLEN,DOBESIN; Anfamon; Keramik; Keramin; Modulor; Parabolin; UNII-I535TOV6LY; UNII-P1A5AE6Q2R; C06954; D07444; Tenuate hydrochloride; (+)-Amfepramone; (-)-Amfepramone; UR 1423; (+-)-diethylpropion; Diethylpropion (BAN); Fenyl-(1-diethylaminoethyl)keton [Czech]; Amfepramone, (+)-; Amfepramone, (-)-; Fenyl-(1-diethylaminoethyl)keton; HSDB 3059; I535TOV6LY; P1A5AE6Q2R; Diethylpropion, (+}-; Diethylpropion, (-)-; NCGC00167475-01; EINECS 202-019-1; BRN 2804400; 1-Phenyl-2-diethylaminopropanone-1 hydrochloride; Propiophenone, 2-(diethylamino)-, hydrochloride; Propiophenone, 2-diethylamino-; (+)-2-Diethylaminopropiophenone; (-)-2-Diethylaminopropiophenone; (+/-)-diethylpropion; SCHEMBL27330; 1-Propanone, 2-(diethylamino)-1-phenyl-, (+)-; 1-Propanone, 2-(diethylamino)-1-phenyl-, (-)-; 4-14-00-00144 (Beilstein Handbook Reference); GTPL7161; CHEMBL1194666; DTXSID6022929; MFCD00056154; AKOS025401369; DB00937; J4.327C; MCULE-3905795013; 2-Diethylaminopropiophenone hydrochloride; 39648-49-2; 39648-50-5; AC-13099; 2-(Diethylamino)-1-phenyl-1-propanone #; 1-Phenyl-2-diethylamino-1-propanone hydrochloride; Q2356505; BRD-A37288617-003-01-4
Clinical Status
Approved
Disease Indication Obesity ICD-11: 5B81 [1]
PubChem CID
7029
Formula
C13H19NO
Canonical SMILES
CCN(CC)C(C)C(=O)C1=CC=CC=C1
InChI
1S/C13H19NO/c1-4-14(5-2)11(3)13(15)12-9-7-6-8-10-12/h6-11H,4-5H2,1-3H3
InChIKey
XXEPPPIWZFICOJ-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=7029"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 205.3 Topological Polar Surface Area 20.3
XlogP 2.8 Complexity 193
Heavy Atom Count 15 Rotatable Bond Count 5
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 2
Full List of Drug Formulations (DFMs) Containing This API
          Diethylpropion 25 mg tablet Click to Show/Hide the Full List of Formulation(s):          5 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Mannitol; Tartaric acid; Zinc stearate; Talc; Povidone; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Aidarex Pharmaceuticals; Lannett Company; NuCare Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Tartaric acid; Crospovidone; Starch, corn
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; Aidarex Pharmaceuticals; KVK Tech; PD-Rx Pharmaceuticals; Unit Dose Services
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Tartaric acid; Talc; Starch, corn
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; Actavis Pharma; Apotheca; Keltman Pharmaceuticals; NuCare Pharmaceuticals; PD-Rx Pharmaceuticals; Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose, unspecified form; Magnesium stearate; Tartaric acid; Talc; Starch, corn
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; Bryant Ranch Prepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Tartaric acid; Starch, corn
                   Dosage Form Oral Tablet
                   Company CorePharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Diethylpropion 75 mg tablet Click to Show/Hide the Full List of Formulation(s):          6 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Mannitol; Tartaric acid; Zinc stearate; Povidone; Carbomer 934
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company A-S Medication Solutions; Apotheca; Blenheim Phamacal; Keltman Pharmaceuticals; Physicians Total Care; Rebel Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Mannitol; Tartaric acid; Povidone k30; Carbomer homopolymer type a; Hypromellose acetate succinate 06081224 (3 mm2/s)
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company PD-Rx Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Mannitol; Tartaric acid; Povidone k30; Carbomer homopolymer type a (allyl pentaerythritol crosslinked); Hypromellose acetate succinate 06081224 (3 mm2/s)
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company A-S Medication Solutions; Aidarex Pharmaceuticals; Preferred Pharamaceuticals; Proficient Rx
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Mannitol; Tartaric acid; Povidone k30; Carbomer homopolymer type a; Hypromellose acetate succinate 06081224 (3 mm2/s)
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Lannett Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Mannitol; Tartaric acid; Zinc stearate; Carbomer homopolymer type b (allyl sucrose crosslinked); Povidone, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company A-S Medication Solutions
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [2]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Mannitol; Tartaric acid; Zinc stearate; Carbomer homopolymer type b (allyl sucrose crosslinked); Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Actavis Pharma; Apotheca; Bryant Ranch Prepack; NuCare Pharmaceuticals; PD-Rx Pharmaceuticals; Preferred Pharamaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [2]
          Diethylpropion Hydrochloride 25mg tablet Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Tartaric Acid; Mannitol; Lactose Monohydrate; Cellulose, Microcrystalline; Povidone; Talc; Zinc Stearate
                   Dosage Form Tablet
                   Company Lannett
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Crospovidone; Lactose, Unspecified Form; Magnesium Stearate; Starch, Corn; Tartaric Acid
                   Dosage Form Tablet
                   Company Bryant Ranch Prepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Crospovidone; Lactose; Magnesium Stearate; Starch, Corn; Tartaric Acid
                   Dosage Form Tablet
                   Company Pd-Rx Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
References
1 FDA label for approved diethylpropion from the official website of the U.S. Food and Drug Administration.
2 Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective. Bioorg Med Chem Lett. 2017 Jun 1; 27(11):2239-2258.
3 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
4 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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