General Information of DFM (ID: F05880)
Name	Diethylpropion 75 mg tablet
Company	A-S Medication Solutions
Active Pharmaceutical Ingredient (API)	Diethylpropion		API Info click to show the detail info of this API
	Obesity		ICD-11: 5B81	Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0Q6DQ	DIG Info	Mannitol	Diluent ...
	E06RNC	DIG Info	Tartaric acid	Acidulant ...
	E0U3AI	DIG Info	Zinc stearate	lubricant

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Transmembrane channel/porin (TC/P)
DBT Name: Glycine receptor alpha-1 (GLRA1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Mannitol
Biological Activity	EC50 = 12589.25 nM (estimated based on the structural similarity with CHEMBL604608 )					[1]
Structural Similarity	Tanimoto coefficient = 0.804878049
Tested Species	Homo sapiens (Human)
UniProt ID	GLRA1_HUMAN

References
1	Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective. Bioorg Med Chem Lett. 2017 Jun 1; 27(11):2239-2258.

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