Details of the Active Pharmaceutical Ingredient (API)
General Information of API (ID: D00218) | |||||
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Name |
Dronedarone
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Synonyms |
Click to Show/Hide the Synonyms of This API
Dronedarone; 141626-36-0; Multaq; SR 33589; SR 33589B; UNII-JQZ1L091Y2; SR33589; N-(2-Butyl-3-(p-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)methanesulfonamide; N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanesulfonamide; N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)-methanesulfonamide; CHEMBL184412; JQZ1L091Y2; CHEBI:50659; N-[2-butyl-3-{4-[3-(dibutylamino)propoxy]benzoyl}-1-benzofuran-5-yl]methanesulfonamide; NCGC00188863-01; DSSTox_CID_28579; DSSTox_RID_82850; Methanesulfonamide, N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)-; Methanesulfonamide, N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]-; DSSTox_GSID_48653; N-(2-butyl-3-{4-[3-(dibutylamino)propoxy]benzoyl}-1-benzofuran-5-yl)methanesulfonamide; Dronedarone (INN); CAS-141626-36-0; Dronedarone [INN:BAN]; C31H44N2O5S; HSDB 7928; DRONEDARONE BASE; cc-334; SCHEMBL110363; GTPL7465; MET037; DTXSID3048653; HMS3749G19; BCP21326; HY-A0016; Tox21_113008; BDBM50151864; MFCD00910331; SR-33598B; STL451011; ZINC49933061; AKOS005145680; Tox21_113008_1; AC-5012; CS-0384; DB04855; MCULE-5052395136; NCGC00188863-02; NCGC00188863-10; AB0022262; FT-0651916; D02537; W-5212; AB01566893_01; 626D360; A807786; L001445; Q408637; J-520428; Multaq; SR-33589; SR33589; SR 33589; SR-33589B; N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)benzofuran-5-yl) methanesulfonamide; N-[2-butyl-3-(p-{3-(dibutylamino)propoxy} benzoyl)-5-benzofuranyl]methanesulfonamide; n-[2-butyl-3-({4-[3-(dibutylamino)propoxy]phenyl}carbonyl)-1-benzofuran-5-yl]methanesulfonamide; N-[2-butyl-3-[[4-[3-(dibutylamino)propoxy]phenyl]-oxomethyl]-5-benzofuranyl]methanesulfonamide; N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]phenyl]carbonyl-1-benzofuran-5-yl]methanesulfonamide
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Clinical Status |
Approved
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Disease Indication | Atrial fibrillation | ICD-11: BC81 | [1] | ||
PubChem CID | |||||
Formula |
C31H44N2O5S
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Canonical SMILES |
CCCCC1=C(C2=C(O1)C=CC(=C2)NS(=O)(=O)C)C(=O)C3=CC=C(C=C3)OCCCN(CCCC)CCCC
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InChI |
1S/C31H44N2O5S/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3/h13-18,23,32H,5-12,19-22H2,1-4H3
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InChIKey |
ZQTNQVWKHCQYLQ-UHFFFAOYSA-N
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Click to Show/Hide the Molecular Data (Structure/Property) of This API | |||||
Structure |
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=208898"></iframe>
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3D MOL is unavailable | 2D MOL | ||||
Physicochemical Properties | Molecular Weight | 556.8 | Topological Polar Surface Area | 97.2 | |
XlogP | 7.2 | Complexity | 800 | ||
Heavy Atom Count | 39 | Rotatable Bond Count | 18 | ||
Hydrogen Bond Donor Count | 1 | Hydrogen Bond Acceptor Count | 7 | ||
Full List of Drug Formulations (DFMs) Containing This API | ||||||
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Dronedarone Hydrochloride eq 400mg base tablet | Click to Show/Hide the Full List of Formulation(s): 1 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Hypromellose; Starch; Crospovidone; Poloxamer 407; Lactose Monohydrate; Colloidal Silicon Dioxide; Magnesium Stearate; Polyethylene Glycol 6000; Titanium Dioxide; Carnauba Wax
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Dosage Form | Tablet | |||||
Company | Sanofi Aventis Us | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Hypromellose | DIG Info | Cytochrome P450 3A5 (IC50 = 19.4 uM) | [2] | |||
Poloxamer 407 | DIG Info | Albendazole monooxygenase (EC50 = 32.8 uM) | [2] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [3] | |||
Crospovidone | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [3] | |||
Polyethylene glycol 6000 | DIG Info | Albendazole monooxygenase (Inhibition ratio < 70 %) | [4] | |||
Pregelatinized starch | DIG Info | Multidrug resistance protein 1 (Protein expression downregulation) | [3] | |||
Dronedarone 400 mg tablet | Click to Show/Hide the Full List of Formulation(s): 3 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Titanium dioxide; Crospovidone; Poloxamer 407; Polyethylene glycol 6000; Silicon dioxide; Carnauba wax; Hypromelloses; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Physicians Total Care | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Poloxamer 407 | DIG Info | Albendazole monooxygenase (EC50 = 32.8 uM) | [2] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [3] | |||
Crospovidone | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [3] | |||
Polyethylene glycol 6000 | DIG Info | Albendazole monooxygenase (Inhibition ratio < 70 %) | [4] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [3] | |||
Drug Formulation 2 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Titanium dioxide; Poloxamer 407; Polyethylene glycol 6000; Silicon dioxide; Carnauba wax; Crospovidone (15 mpa.s at 5%); Hypromellose, unspecified; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Sanofi-Aventis | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Poloxamer 407 | DIG Info | Albendazole monooxygenase (EC50 = 32.8 uM) | [2] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [3] | |||
Polyethylene glycol 6000 | DIG Info | Albendazole monooxygenase (Inhibition ratio < 70 %) | [4] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [3] | |||
Drug Formulation 3 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Titanium dioxide; Poloxamer 407; Polyethylene glycol 6000; Silicon dioxide; Carnauba wax; Crospovidone (15 mpa.s at 5%); Hypromelloses; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Cardinal Health | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Poloxamer 407 | DIG Info | Albendazole monooxygenase (EC50 = 32.8 uM) | [2] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [3] | |||
Polyethylene glycol 6000 | DIG Info | Albendazole monooxygenase (Inhibition ratio < 70 %) | [4] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [3] | |||
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