Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00248)
Name
Conjugated estrogen
Synonyms    Click to Show/Hide the Synonyms of This API
Equilin sodium sulfate; Sodium equilin sulfate; 16680-47-0; Conjugated Estrogen; Sodium equilin 3-monosulfate; Equilin 3-Sulfate Sodium Salt; 12126-59-9; UNII-7XY8FW3E68; Conjugated Estrogen sodium; 7XY8FW3E68; Climarest; Dagynil; Estratab; Femavit; Presomen; Transannon; Oestro-feminal; Estra-1,3,5(10),7-tetraen-17-one, 3-(sulfooxy)-, sodium salt; Estrogens, conjugates; Estrogens, Conjugated; Climestrone; Emopremarin; Novoconestron; Ayerogen; Cenestin; Conestron; Conjugen; Conjutabs; Equigyne; Estrifol; Estroate; Estrocon; Estrogens; Estromed; Estropan; Femacoid; Formatrix; Ganeake; Genisis; Glyestrin; Hyphorin; Kestrin; Mannest; Menogen; Menotab; Menotrol; Oestrilin; Palopause; Premaril; Premarina; Premarose; Prempak; Primarin; Promarit; Sukingpo; Theogen; Azumon; Conest; Conjes; Femest; Menpoz; Romeda; Srogen; Premarin Creme; Neo-Menovar; Sodestrin-H; Menopak-E; Oestropak morning; Prevagin-Premaril; Premarin Crema V; CO-Estro; Provette Continuous; Conjugated estrogenic hormones; Ayerogen Crema Vaginal; Premarin Vaginal Creme; Conjugated equine estrogen; Estroplus; CCRIS 7207; TAG-39; Estrogenic substances, conjugated; Estrogens conjugated; EINECS 235-199-5; EINECS 240-727-2; Equilin, sulfate, sodium salt (6CI); Estrogens Conjugated; Conjugated estrogens: sodium equilin sulfate; Estrogens conjugated [USP]; SCHEMBL974791; C.E.S.; Estrogenic substances, cojugated; CHEBI:32143; HSDB 3076; DTXSID00872961; Estrogens, conjugated synthetic A; Sodium estrone sulfate, mixted with sodium equilin sulfate; Estrogens, conjugated [USP:JAN]; C13416; J-004475; 17-Oxoestra-1,3,5(10),7-tetraen-3-yl sodium sulfate; UNII-3ASP8Q3768 component QTTMOCOWZLSYSV-QWAPEVOJSA-M; UNII-8L6LAK9BTR component QTTMOCOWZLSYSV-QWAPEVOJSA-M; UNII-IU5QR144QX component QTTMOCOWZLSYSV-QWAPEVOJSA-M; UNII-JM2621P2LS component QTTMOCOWZLSYSV-QWAPEVOJSA-M; Estra-1,3,5(10),7-tetraen-17-one,3-(sulfooxy)-,sodium salt; Estra-1,3,5(10),7-tetraen-17-one, 3-hydroxy-, hydrogen sulfate sodium salt (8CI)
Clinical Status
Approved
Disease Indication Osteoporosis ICD-11: FB83 [1]
PubChem CID
23676225
Formula
C18H19NaO5S
Canonical SMILES
C[C@]12CC[C@H]3C(=CCC4=C3C=CC(=C4)OS(=O)(=O)[O-])[C@@H]1CCC2=O.[Na+]
InChI
1S/C18H20O5S.Na/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;/h3-5,10,14,16H,2,6-9H2,1H3,(H,20,21,22);/q;+1/p-1/t14-,16+,18+;/m1./s1
InChIKey
QTTMOCOWZLSYSV-QWAPEVOJSA-M
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=23676225"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 370.4 Topological Polar Surface Area 91.9
XlogP N.A. Complexity 682
Heavy Atom Count 25 Rotatable Bond Count 2
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 5
Full List of Drug Formulations (DFMs) Containing This API
          Conjugated estrogen 1.25 mg tablet Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Fd&c yellow no. 6; Magnesium stearate; Ferrosoferric oxide; Sucrose; Titanium dioxide; Polyethylene glycol 400; Carnauba wax; Hydroxypropyl cellulose (1200000 mw); Hypromellose 2208 (15000 mpa.s); Hypromellose 2910 (15 mpa.s); Hypromellose 2910 (6 mpa.s); Microcrystalline cellulose; Powdered cellulose; Tribasic calcium phosphate
                   Dosage Form Oral Tablet
                   Company Pfizer
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Fd&c yellow no. 6; Magnesium stearate; Ferrosoferric oxide; Sucrose; Titanium dioxide; Polyethylene glycol 400; Carnauba wax; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromellose 2208 (15000 mpa.s); Hypromellose 2910 (15 mpa.s); Hypromellose 2910 (6 mpa.s); Powdered cellulose; Tribasic calcium phosphate
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Fd&c yellow no. 6; Magnesium stearate; Ferrosoferric oxide; Sucrose; Titanium dioxide; Polyethylene glycol 400; Carnauba wax; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromellose 2208 (15000 mpa.s); Hypromellose 2910 (15 mpa.s); Hypromellose 2910 (6 mpa.s); Powdered cellulose; Tribasic calcium phosphate
                   Dosage Form Oral Tablet
                   Company Lake Eire Medical & Surgical Supply DBA Quality Care Products
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [5]
          Conjugated estrogen 0.3 mg tablet Click to Show/Hide the Full List of Formulation(s):          4 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Fd&c blue no. 2; Magnesium stearate; Sucrose; Titanium dioxide; Polyethylene glycol 400; Carnauba wax; Hydroxypropyl cellulose (1200000 mw); Hypromellose 2208 (15000 mpa.s); Hypromellose 2910 (15 mpa.s); Hypromellose 2910 (6 mpa.s); Microcrystalline cellulose; Powdered cellulose; Tribasic calcium phosphate
                   Dosage Form Oral Tablet
                   Company Pfizer
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Fd&c blue no. 2; Magnesium stearate; Sucrose; Titanium dioxide; Polyethylene glycol 400; Carnauba wax; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromellose 2208 (15000 mpa.s); Hypromellose 2910 (15 mpa.s); Hypromellose 2910 (6 mpa.s); Powdered cellulose; Tribasic calcium phosphate
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Fd&c blue no. 2; Magnesium stearate; Sucrose; Titanium dioxide; Polyethylene glycol 400; Carnauba wax; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromellose 2208 (15000 mpa.s); Hypromellose 2910 (15 mpa.s); Hypromellose 2910 (6 mpa.s); Powdered cellulose; Tribasic calcium phosphate
                   Dosage Form Oral Tablet
                   Company Aphena Pharma Solutions-Tennessee; Lake Eire Medical & Surgical Supply DBA Quality Care Products
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Fd&c blue no. 2; Sucrose; Titanium dioxide; Polyethylene glycol 400; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromellose 2208 (15000 mpa.s); Hypromellose 2910 (15 mpa.s); Hypromellose 2910 (6 mpa.s); Powdered cellulose; Tribasic calcium phosphate
                   Dosage Form Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [5]
          Conjugated estrogen 0.625 mg tablet Click to Show/Hide the Full List of Formulation(s):          5 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c red no. 40; Fd&c blue no. 2; Magnesium stearate; Sucrose; Titanium dioxide; Polyethylene glycol 400; Carnauba wax; Hydroxypropyl cellulose (1200000 mw); Hypromellose 2208 (15000 mpa.s); Hypromellose 2910 (15 mpa.s); Hypromellose 2910 (6 mpa.s); Microcrystalline cellulose; Powdered cellulose; Tribasic calcium phosphate
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; Pfizer
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c red no. 40; Fd&c blue no. 2; Magnesium stearate; Sucrose; Titanium dioxide; Polyethylene glycol 400; Carnauba wax; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromellose 2208 (15000 mpa.s); Hypromellose 2910 (15 mpa.s); Hypromellose 2910 (6 mpa.s); Powdered cellulose; Tribasic calcium phosphate
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c red no. 40; Fd&c blue no. 2; Magnesium stearate; Sucrose; Titanium dioxide; Polyethylene glycol 400; Carnauba wax; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromellose 2208 (15000 cps); Hypromellose 2910 (15 cps); Hypromellose 2910 (6 cps); Powdered cellulose; Tribasic calcium phosphate
                   Dosage Form Oral Tablet
                   Company State of Florida DOH Central Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c red no. 40; Fd&c blue no. 2; Magnesium stearate; Sucrose; Titanium dioxide; Polyethylene glycol 400; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromellose 2208 (15000 mpa.s); Hypromellose 2910 (15 mpa.s); Hypromellose 2910 (6 mpa.s); Powdered cellulose; Tribasic calcium phosphate
                   Dosage Form Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [5]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c red no. 40; Fd&c blue no. 2; Magnesium stearate; Sucrose; Titanium dioxide; Polyethylene glycol 400; Carnauba wax; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromellose 2208 (15000 mpa.s); Hypromellose 2910 (15 mpa.s); Hypromellose 2910 (6 mpa.s); Powdered cellulose; Tribasic calcium phosphate
                   Dosage Form Oral Tablet
                   Company Aphena Pharma Solutions-Tennessee; Lake Eire Medical & Surgical Supply DBA Quality Care Products
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [5]
          Conjugated estrogen 0.9 mg tablet Click to Show/Hide the Full List of Formulation(s):          4 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c red no. 30; D&c red no. 7; Magnesium stearate; Sucrose; Titanium dioxide; Polyethylene glycol 400; Carnauba wax; Hydroxypropyl cellulose (1200000 mw); Hypromellose 2208 (15000 mpa.s); Hypromellose 2910 (15 mpa.s); Hypromellose 2910 (6 mpa.s); Microcrystalline cellulose; Powdered cellulose; Tribasic calcium phosphate
                   Dosage Form Oral Tablet
                   Company Cardinal Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c red no. 30; D&c red no. 7; Magnesium stearate; Sucrose; Titanium dioxide; Polyethylene glycol 400; Carnauba wax; Hydroxypropyl cellulose (1200000 mw); Hypromellose 2208 (15000 mpa.s); Hypromellose 2910 (15 mpa.s); Hypromellose 2910 (6 mpa.s); Microcrystalline cellulose; Powdered cellulose; Tribasic calcium phosphate
                   Dosage Form Oral Tablet
                   Company Pfizer
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c red no. 30; D&c red no. 7; Magnesium stearate; Sucrose; Titanium dioxide; Polyethylene glycol 400; Carnauba wax; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromellose 2208 (15000 mpa.s); Hypromellose 2910 (15 mpa.s); Hypromellose 2910 (6 mpa.s); Powdered cellulose; Tribasic calcium phosphate
                   Dosage Form Oral Tablet
                   Company Avera McKennan Hospital
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c red no. 30; D&c red no. 7; Magnesium stearate; Sucrose; Titanium dioxide; Polyethylene glycol 400; Carnauba wax; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromellose 2208 (15000 mpa.s); Hypromellose 2910 (15 mpa.s); Hypromellose 2910 (6 mpa.s); Powdered cellulose; Tribasic calcium phosphate
                   Dosage Form Oral Tablet
                   Company Lake Eire Medical & Surgical Supply DBA Quality Care Products
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [5]
          Conjugated estrogen 0.45 mg tablet Click to Show/Hide the Full List of Formulation(s):          4 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c blue no. 2; Magnesium stearate; Sucrose; Titanium dioxide; Polyethylene glycol 400; Carnauba wax; Hydroxypropyl cellulose (1200000 mw); Hypromellose 2208 (15000 mpa.s); Hypromellose 2910 (15 mpa.s); Hypromellose 2910 (6 mpa.s); Microcrystalline cellulose; Powdered cellulose; Tribasic calcium phosphate
                   Dosage Form Oral Tablet
                   Company Cardinal Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c blue no. 2; Magnesium stearate; Sucrose; Titanium dioxide; Polyethylene glycol 400; Carnauba wax; Hydroxypropyl cellulose (1200000 mw); Hypromellose 2208 (15000 mpa.s); Hypromellose 2910 (15 mpa.s); Hypromellose 2910 (6 mpa.s); Microcrystalline cellulose; Powdered cellulose; Tribasic calcium phosphate
                   Dosage Form Oral Tablet
                   Company Pfizer
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c blue no. 2; Magnesium stearate; Sucrose; Titanium dioxide; Polyethylene glycol 400; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromellose 2208 (15000 mpa.s); Hypromellose 2910 (15 mpa.s); Hypromellose 2910 (6 mpa.s); Powdered cellulose; Tribasic calcium phosphate
                   Dosage Form Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c blue no. 2; Magnesium stearate; Sucrose; Titanium dioxide; Polyethylene glycol 400; Carnauba wax; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromellose 2208 (15000 mpa.s); Hypromellose 2910 (15 mpa.s); Hypromellose 2910 (6 mpa.s); Powdered cellulose; Tribasic calcium phosphate
                   Dosage Form Oral Tablet
                   Company Lake Eire Medical & Surgical Supply DBA Quality Care Products
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [5]
References
1 FDA label for approved conjugated estrogen from the official website of the U.S. Food and Drug Administration.
2 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
3 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
4 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
5 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
6 PubChem BioAssay data set.

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