Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00375)
Name
Lorazepam
Synonyms    Click to Show/Hide the Synonyms of This API
lorazepam; Ativan; 846-49-1; o-Chloroxazepam; o-Chlorooxazepam; Temesta; Delormetazepam; Almazine; Anxiedin; Bonatranquan; Duralozam; Emotival; Lorabenz; Sedatival; Laubeel; Orfidal; Punktyl; Apo-Lorazepam; Lorazepam Intensol; Norlormetazepam; Anzepam; Aplacasse; Azurogen; Efasedan; Equitam; Kalmalin; Larpose; Lorapam; Lorazene; Lorazep; Lorazin; Lorenin; Loridem; Lorsedal; Lozepam; Novhepar; Renaquil; Rocosgen; Sedizepan; Sidenar; Silence; Tranqipam; Anxira; Aripax; Bonton; Merlit; Stapam; Trapax; Nervistop L; Demethyllormetazepam; Lorazepamum; Wy 4036; Wy-4036; 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one; (+/-)-Lorazepam; Lorazepam preservative free; 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-; NSC 289758; Idalprem; 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one; Aplacassee; Sinestron; CHEMBL580; 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one; Lorazepam Medical; Nu Loraz; 7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one; Nervistopl; Novolorazem; Emotion; Lomesta; Lorafen; Lorazon; Lorivan; Somagerol; Vigiten; Lorans; Lorzem; Lorazepam Fabra; Lorazepam-Efeka; Lorazepan Chobet; Lorazepan Richet; Max Pax; NSC289758; Lorazepam Genericon; Lorazepam Lannacher; NSC-289758; NCGC00159439-02; Lorsilan; Securit; Sedazin; Pro dorm; 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-; Lorazepamum [INN-Latin]; Ativan (TN); EINECS 212-687-6; BRN 0759084; Lorazepam civ; DEA No. 2885; Lorazepam [USAN:USP:INN:BAN:JAN]; (.+/-.)-Lorazepam; DSSTox_CID_3225; DSSTox_RID_76932; DSSTox_GSID_23225; SCHEMBL26961; 5-25-02-00248 (Beilstein Handbook Reference); MLS001424236; DivK1c_000965; Lorazepam (JP17/USP/INN); CHEBI:6539; GTPL5884; DTXSID7023225; HMS503A11; KBio1_000965; NINDS_000965; HMS2052H07; HMS3394H07; BCP13713; Tox21_111669; BDBM50292627; Lorazepam 0.1 mg/ml in Acetonitrile; Lorazepam 1.0 mg/ml in Acetonitrile; AKOS015904303; CCG-101170; DB00186; NC00420; IDI1_000965; CAS-846-49-1; SMR000058410; WLN: T67 GMV JN IHJ CG IQ KR BG; D00365; 846L491; A840886; Q408265; 7-Chloro-5-(o-chlorophenyl)-1,4-benzodiazepin-2-one; BRD-A11990600-001-01-8; Lorazepam, British Pharmacopoeia (BP) Reference Standard; Lorazepam, European Pharmacopoeia (EP) Reference Standard; 2H-1, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-; 2H-1, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-; Lorazepam, United States Pharmacopeia (USP) Reference Standard; O-Chloroxazepam; O-Chlorooxazepam; Almazine; WY 4036; WY-4036; WY4036; 7-chloranyl-5-(2-chlorophenyl)-3-oxidanyl-1,3-dihydro-1,4-benzodiazepin-2-one; 7-chloro-3-hydroxy-5-(2'-chloro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-one; 7-chloro-3-hydroxy-5-(2'-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-one; 7-Chloro-5-(2-chloro-phenyl)-3-hydroxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one; 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepine-2-one; 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one.; 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one #; 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-benzo[e][1,4]diazepin-2(3H)-one; 7-chloro-5-(2-chlorophenyl)-3-hydroxy-2,3-dihydro-1H-1,4-benzodiazepin-2-one; Lorazepam for system suitability, European Pharmacopoeia (EP) Reference Standard
Clinical Status
Approved
Disease Indication Anxiety disorder ICD-11: 6B00 [1]
PubChem CID
3958
Formula
C15H10Cl2N2O2
Canonical SMILES
C1=CC=C(C(=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O)Cl
InChI
1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)
InChIKey
DIWRORZWFLOCLC-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=3958"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 321.2 Topological Polar Surface Area 61.7
XlogP 2.4 Complexity 443
Heavy Atom Count 21 Rotatable Bond Count 1
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Full List of Drug Formulations (DFMs) Containing This API
          Lorazepam 0.5 mg tablet Click to Show/Hide the Full List of Formulation(s):        21 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium stearyl fumarate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company Aphena Pharma Solutions-Tennessee; McKesson; NCS HealthCare of KY, Inc dba Vangard Labs; Proficient Rx; RedPharm; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [2]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium stearyl fumarate; Microcrystalline cellulose; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company Cardinal Health; Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [2]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Hypromellose; Starch, corn
                   Dosage Form Oral Tablet
                   Company McKesson
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company McKesson; Rebel Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company Aidarex Pharmaceuticals; Leading Pharma; NCS HealthCare of KY, Inc dba Vangard Labs; NuCare Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Microcrystalline cellulose; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company Aphena Pharma Solutions-Tennessee; Major Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company Preferred Pharamaceuticals; Ranbaxy Pharmaceuticals; TYA Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Alcohol; Hypromelloses; Starch, corn
                   Dosage Form Oral Tablet
                   Company Rebel Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; Actavis Pharma; Aphena Pharma Solutions-Tennessee; Bryant Ranch Prepack; Lake Eire Medical & Surgical Supply DBA Quality Care Products; McKesson; PD-Rx Pharmaceuticals; Physicians Total Care; Stat Rx USA
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Hydroxypropyl cellulose, low substituted
                   Dosage Form Oral Tablet
                   Company Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company Actavis Elizabeth; Aidarex Pharmaceuticals; American Health Packaging; Cardinal Health; Contract Pharmacal; Dispensing Solution; Excellium Pharmaceutical; Kaiser Foundation Hospitals; Major Pharmaceuticals; NuCare Pharmaceuticals; Preferred Pharamaceuticals; RemedyRepack; Sandoz; Stat Rx USA; Unit Dose Services; Upsher-Smith Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Cardinal Health; Kaiser Foundation Hospitals; NCS HealthCare of KY, Inc dba Vangard Labs; Qualitest Pharmaceuticals; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Microcrystalline cellulose; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company McKesson; Proficient Rx
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company BTA Pharmaceuticals; Valeant Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 15 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company RedPharm; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 16 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 17 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company DirectRX; RedPharm
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 18 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company DirectRX
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 19 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company RedPharm
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 20 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company RedPharm
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 21 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Lorazepam 1 mg tablet Click to Show/Hide the Full List of Formulation(s):        19 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium stearyl fumarate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company Aphena Pharma Solutions-Tennessee; Lake Eire Medical & Surgical Supply DBA Quality Care Products; McKesson; Proficient Rx; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [2]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium stearyl fumarate; Microcrystalline cellulose; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company Cardinal Health; Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [2]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Hypromellose; Starch, corn
                   Dosage Form Oral Tablet
                   Company McKesson
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company McKesson; Rebel Distributors; RedPharm
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company Aidarex Pharmaceuticals; Leading Pharma; NCS HealthCare of KY, Inc dba Vangard Labs; NuCare Pharmaceuticals; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Microcrystalline cellulose; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company Major Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company Apotheca; Blenheim Phamacal; Lake Eire Medical & Surgical Supply DBA Quality Care Products; Preferred Pharamaceuticals; Ranbaxy Pharmaceuticals; TYA Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Alcohol; Hypromelloses; Starch, corn
                   Dosage Form Oral Tablet
                   Company Rebel Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; Actavis Pharma; Aphena Pharma Solutions-Tennessee; Blenheim Phamacal; Cardinal Health; Lake Eire Medical & Surgical Supply DBA Quality Care Products; Life Line Home Care Services; McKesson; PD-Rx Pharmaceuticals; Physicians Total Care; RedPharm; Stat Rx USA
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Hydroxypropyl cellulose, low substituted
                   Dosage Form Oral Tablet
                   Company Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company Actavis Elizabeth; Aidarex Pharmaceuticals; American Health Packaging; Blenheim Phamacal; Cardinal Health; Contract Pharmacal; DirectRX; Dispensing Solution; Excellium Pharmaceutical; Kaiser Foundation Hospitals; Lake Eire Medical & Surgical Supply DBA Quality Care Products; Major Pharmaceuticals; NuCare Pharmaceuticals; Preferred Pharamaceuticals; Proficient Rx; Rebel Distributors; RedPharm; RemedyRepack; Sandoz; St Marys Medical Park Pharmacy; Stat Rx USA; Upsher-Smith Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; Aphena Pharma Solutions-Tennessee; Cardinal Health; Kaiser Foundation Hospitals; NCS HealthCare of KY, Inc dba Vangard Labs; Qualitest Pharmaceuticals; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Microcrystalline cellulose; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company McKesson
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; BTA Pharmaceuticals; Cardinal Health; Valeant Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 15 DFM Info click to show the detail info of this DFM
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Lactose; Magnesium stearate; Hypromellose 2910 (3 mpa.s); Starch, corn
                   Dosage Form Oral Tablet
                   Company RedPharm
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 16 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company Stat Rx USA
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 17 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose, unspecified form; Magnesium stearate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company Preferred Pharamaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 18 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose, unspecified form; Magnesium stearate; Microcrystalline cellulose; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company Bryant Ranch Prepack; Unit Dose Services
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 19 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Microcrystalline cellulose; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company McKesson
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Lorazepam 2 mg tablet Click to Show/Hide the Full List of Formulation(s):        15 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium stearyl fumarate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company Aphena Pharma Solutions-Tennessee; McKesson; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [2]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium stearyl fumarate; Microcrystalline cellulose; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company Cardinal Health; Mylan Pharamceuticals; Proficient Rx
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [2]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Hypromellose; Starch, corn
                   Dosage Form Oral Tablet
                   Company McKesson
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company McKesson; Rebel Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company Leading Pharma; NCS HealthCare of KY, Inc dba Vangard Labs; NuCare Pharmaceuticals; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Microcrystalline cellulose; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company Major Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company Ranbaxy Pharmaceuticals; RxChange
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Alcohol; Hypromelloses; Starch, corn
                   Dosage Form Oral Tablet
                   Company Rebel Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; Actavis Pharma; Aphena Pharma Solutions-Tennessee; Bryant Ranch Prepack; McKesson; PD-Rx Pharmaceuticals; Physicians Total Care; Stat Rx USA; TYA Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Hydroxypropyl cellulose, low substituted
                   Dosage Form Oral Tablet
                   Company Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company Actavis Elizabeth; Aidarex Pharmaceuticals; American Health Packaging; Contract Pharmacal; Dispensing Solution; Excellium Pharmaceutical; Lake Eire Medical & Surgical Supply DBA Quality Care Products; Major Pharmaceuticals; NuCare Pharmaceuticals; Sandoz; Unit Dose Services; Upsher-Smith Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Cardinal Health; NCS HealthCare of KY, Inc dba Vangard Labs; Qualitest Pharmaceuticals; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Microcrystalline cellulose; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company McKesson
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company BTA Pharmaceuticals; Valeant Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 15 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
References
1 FDA label for approved lorazepam from the official website of the U.S. Food and Drug Administration.
2 Synthesis and evaluation of (-)-Massoialactone and analogues as potential anticancer and anti-inflammatory agents. Eur J Med Chem. 2014 Apr 9; 76:291-300.
3 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
4 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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