General Information of DFM (ID: F12544)
Name
Lorazepam 0.5 mg tablet
Company
Actavis Elizabeth; Aidarex Pharmaceuticals; American Health Packaging; Cardinal Health; Contract Pharmacal; Dispensing Solution; Excellium Pharmaceutical; Kaiser Foundation Hospitals; Major Pharmaceuticals; NuCare Pharmaceuticals; Preferred Pharamaceuticals; RemedyRepack; Sandoz; Stat Rx USA; Unit Dose Services; Upsher-Smith Laboratories
Active Pharmaceutical Ingredient (API) Lorazepam API Info click to show the detail info of this API
Anxiety disorder ICD-11: 6B00 Approved
Drug Inactive Ingredient (DIGs)
DIG ID DIG Info DIG Name DIG Functional Class
E00DHW DIG Info Lactose monohydrate Binding agent ...
E01UTP DIG Info Magnesium stearate lubricant
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
      Oxidoreductase (ORase)
            DBT Name: Albendazole monooxygenase (CYP3A4) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Magnesium stearate
                    Biological Activity Protein expression downregulation (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP3A4_HUMAN
References
1 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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