Details of the Active Pharmaceutical Ingredient (API)
General Information of API (ID: D00613) | |||||
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Name |
Salbutamol
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Synonyms |
Click to Show/Hide the Synonyms of This API
Salbutamol; albuterol; 18559-94-9; Proventil; Sultanol; Volmax; Broncovaleas; Aerolin; dl-Salbutamol; dl-Albuterol; Ventolin Inhaler; Ventolin; Proventil HFA; Buventol; Cobutolin; Salbulin; Salbuvent; Saventol; Ventoline; Asmaven; Salamol; Spreor; Sultanol N; Proventil Inhaler; Novosalmol; Salbuhexal; Salbutalan; Salbutamolum; Servitamol; Ventiloboi; Ventodisks; Almotex; Anebron; Asmadil; Asmanil; Asmasal; Asmatol; Asmidon; Bronter; Bugonol; Butamol; Butohaler; Butotal; Butovent; Dilatamol; Farcolin; Gerivent; Grafalin; Libretin; Medolin; Parasma; Pneumolat; Respolin; Sabutal; Salbetol; Salbron; Salbupur; Salbusian; Salbutan; Salbutol; Salbuven; Sallbupp; Salmaplon; Salomol; Salvent; Suprasma; Theosal; Tobybron; Vencronyl; Ventamol; Ventilan; Zaperin; Respax; Asthalin; Alti-Salbutamol; Broncho-Spray; Salbu-Fatol; Buto-Asma; Asmol Uni-Dose; Ventolin Rotacaps; Salbu-BASF; Salbutamol Sulphate; Volare easi-breathe; 4-[2-(tert-Butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol; Arubendol-Salbutamol; Volare albuterol HFA; Salbutamol sulfate; ALBUTEROL (+/-); AH 3365; (l)-albuterol; 4-(2-(tert-Butylamino)-1-hydroxyethyl)-2-(hydroxymethyl)phenol; alpha-[(tert-Butylamino)methyl]-4-hydroxy-m-xylene-alpha,alpha'-diol; AccuNeb; 2-(tert-Butylamino)-1-(4-hydroxy-3-hydroxymethylphenyl)ethanol; Proventil (TN); Salbutamol (hemisulfate); MFCD00148978; 1-(tert-Butylaminomethyl)-4-hydroxy-m-xylene-alpha1,alpha3-diol; alpha'-((tert-Butylamino)methyl)-4-hydroxy-m-xylene-alpha,alpha'-diol; 4-Hydroxy-3-hydroxymethyl-alpha-((tert-butylamino)methyl)benzyl alcohol; Combivent; DL-N-tert-Butyl-2-(4-hydroxy-3-hydroxymethylphenyl)-2-hydroxyethylamine; alpha(sup 1)-((tert-Butylamino)methyl)-4-hydroxy-m-xylene-alpha,alpha'-diol; CHEBI:2549; Airomir; Ventalin inhaler; SCH-13949W; NCGC00015955-09; Solbutamol; 18559-94-9 (FREE BASE); (R)-Albuterol;(R)-Salbutamol;Levosalbutamol; DSSTox_CID_1255; m-Xylene-alpha,alpha'-diol, alpha'-((tert-butylamino)methyl)-4-hydroxy-; 1,3-Benzenedimethanol, .alpha.1-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-; 4-{2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol; Albuterol (hemisulfate);AH-3365 (hemisulfate); DSSTox_RID_76042; DSSTox_GSID_21255; Salbutamolum [INN-Latin]; Vospire; Eolene; 4-{2-[(tert-butyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol; Albuterol (USP); HSDB 7206; SR-01000075161; Albuterol [USAN:USP]; 51022-70-9; EINECS 242-424-0; BRN 2213614; Salbutamol-d9; racemic salbutamol; Salamol EB; Prestwick_665; CAS-18559-94-9; Salbutamol Free Base; Salbutamol,(+/-); Venetlin (Salt/Mix); Spectrum_000200; Salbutamol [INN:BAN]; Prestwick0_000198; Prestwick1_000198; Prestwick2_000198; Prestwick3_000198; Spectrum2_001350; Spectrum4_000887; Spectrum5_001059; m-Xylene-alpha,alpha'-diol, alpha-((tert-butylamino)methyl)-4-hydroxy-; CHEMBL714; 1,3-Benzenedimethanol, alpha1-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-; EC 242-424-0; S 8260; SCHEMBL4913; Lopac0_001090; Lopac0_001098; BSPBio_000155; GTPL558; KBioGR_001294; KBioSS_000680; 35763-26-9; DivK1c_000943; SPECTRUM1500677; SPBio_001539; SPBio_002076; BPBio1_000171; SGCUT00011; DTXSID5021255; SCHEMBL10025126; BCBcMAP01_000116; BDBM25769; HMS502P05; KBio1_000943; KBio2_000680; KBio2_003248; KBio2_005816; NINDS_000943; Bio1_000446; Bio1_000935; Bio1_001424; HMS1568H17; HMS1921C04; HMS2089I19; HMS2092I08; HMS2095H17; HMS3712H17; HMS3886I08; KUC106739N; Pharmakon1600-01500677; SCH 13949W; 4-[2-(tert-butylamino)-1-hydroxy-ethyl]-2-(hydroxymethyl)phenol; BCP28423; HY-B1037; Salbutamol-(tert-butyl-d9) acetate; to_000081; Tox21_110266; Tox21_200800; CCG-39288; CS0015; NSC757417; PDSP1_000623; PDSP2_000620; SBB066105; AKOS007930174; Tox21_110266_1; CS-4556; DB01001; KS-5209; MCULE-4493408325; NSC-757417; SDCCGSBI-0051060.P006; IDI1_000943; SMP1_000268; NCGC00015955-04; NCGC00015955-05; NCGC00015955-06; NCGC00015955-07; NCGC00015955-08; NCGC00015955-10; NCGC00015955-11; NCGC00015955-12; NCGC00015955-13; NCGC00015955-14; NCGC00015955-16; NCGC00015955-28; NCGC00024698-02; NCGC00024698-03; NCGC00024698-04; NCGC00024698-05; NCGC00024698-06; NCGC00024698-07; NCGC00258354-01; AC-10286; KSC-11-222-1; Salbutamol 100 microg/mL in Acetonitrile; ST024764; ST075204; ST077150; SBI-0051060.P005; AB0011383; AB00052154; EU-0101090; FT-0661467; FT-0770967; VU0243312-5; D02147; J10176; K-5595; Salbutamol, VETRANAL(TM), analytical standard; AB00052154-08; AB00052154-09; AB00052154_10; AB00052154_11; (+)-5,6-O-CYCLOHEXYLIDENE-L-ASCORBICACID; 559S949; A812971; L000531; Q410358; Q-201695; Q-201696; SR-01000075161-3; SR-01000075161-4; SR-01000075161-5; SR-01000075161-8; BRD-A88254928-001-04-6; BRD-A88254928-001-05-3; SR-01000075161-11; Salbutamol, British Pharmacopoeia (BP) Reference Standard; Salbutamol, European Pharmacopoeia (EP) Reference Standard; Albuterol, United States Pharmacopeia (USP) Reference Standard; 2-(tert-Butylamino)-1-[4-hydroxy-3-(hydroxymethyl)phenyl]ethanol; 4-[2-(tert-Butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol #; 4-[2-(tert-butylamino)-1-oxidanyl-ethyl]-2-(hydroxymethyl)phenol; 1-(tert-Butylaminomethyl)-4-hydroxy-m-xylene-.alpha.1,.alpha.3-diol; 4-[(1S)-2-(butylamino)-1-hydroxy-isopropyl]-2-(hydroxymethyl)phenol; 4-Hydroxy-3-hydroxymethyl-.alpha.-((tert-butylamino)methyl)benzyl alcohol; .alpha.'-((tert-Butylamino)methyl)-4-hydroxy-m-xylene-.alpha.,.alpha.'-diol; .alpha.1-[(tert-Butylamino)methyl]-4-hydroxy-m-xylene-.alpha.,.alpha.'-diol; 1,3-Benzenedimethanol, .alpha.(1)-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-; 4-[(1S)-1-hydroxy-2-(propylamino)ethyl]-2-(hydroxymethyl)phenol, oxamethane; m-Xylene-.alpha.,.alpha.'-diol, .alpha.'-((tert-butylamino)methyl)-4-hydroxy-; m-Xylene-.alpha.,.alpha.-diol, .alpha.-1-((tert-butylamino)methyl)-4-hydroxy-; 148563-15-9
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Clinical Status |
Approved
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Disease Indication | Chronic obstructive pulmonary disease | ICD-11: CA22 | [1] | ||
PubChem CID | |||||
Formula |
C13H21NO3
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Canonical SMILES |
CC(C)(C)NCC(C1=CC(=C(C=C1)O)CO)O
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InChI |
1S/C13H21NO3/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15/h4-6,12,14-17H,7-8H2,1-3H3
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InChIKey |
NDAUXUAQIAJITI-UHFFFAOYSA-N
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Click to Show/Hide the Molecular Data (Structure/Property) of This API | |||||
Structure |
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=2083"></iframe>
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3D MOL | 2D MOL | ||||
Physicochemical Properties | Molecular Weight | 239.31 | Topological Polar Surface Area | 72.7 | |
XlogP | 0.3 | Complexity | 227 | ||
Heavy Atom Count | 17 | Rotatable Bond Count | 5 | ||
Hydrogen Bond Donor Count | 4 | Hydrogen Bond Acceptor Count | 4 | ||
Full List of Drug Formulations (DFMs) Containing This API | ||||||
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Salbutamol 4 mg tablet | Click to Show/Hide the Full List of Formulation(s): 4 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; D&c yellow no. 10; Fd&c blue no. 1; Magnesium stearate; Calcium sulfate; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Triacetin; Carnauba wax; Ethylcelluloses; Hypromelloses; Polyethylene glycols; Shellac
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Dosage Form | 12 HR Extended Release Oral Tablet | |||||
Company | DAVA Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
FD&C blue no. 1 | DIG Info | Solute carrier SLCO2B1 (Ki = 13 uM) | [2] | |||
Stearic acid | DIG Info | Phosphodiesterase 3A (IC50 = 3.1 uM) | [3] | |||
Quinoline yellow WS | DIG Info | Estrogen receptor alpha (IC50 = 18 uM) | [3] | |||
Propylene glycol | DIG Info | Albendazole monooxygenase (Inhibition ratio < 20 %) | [4] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Drug Formulation 2 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Magnesium stearate; Titanium dioxide; Triacetin; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polydextrose; Polyethylene glycols; Xanthan gum
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Dosage Form | 12 HR Extended Release Oral Tablet | |||||
Company | Mylan Pharamceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Sodium lauryl sulfate | DIG Info | Solute carrier SLCO2B1 (Ki = 1.98 uM) | [2] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Drug Formulation 3 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Mylan Pharamceuticals; PD-Rx Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Sodium lauryl sulfate | DIG Info | Solute carrier SLCO2B1 (Ki = 1.98 uM) | [2] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Drug Formulation 4 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Sodium starch glycolate type a potato; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Bryant Ranch Prepack | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Salbutamol 8 mg tablet | Click to Show/Hide the Full List of Formulation(s): 2 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Fd&c blue no. 2; Fd&c yellow no. 6; Magnesium stearate; Titanium dioxide; Triacetin; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polydextrose; Polyethylene glycols; Xanthan gum
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Dosage Form | 12 HR Extended Release Oral Tablet | |||||
Company | Mylan Pharamceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Sunset yellow FCF | DIG Info | Solute carrier SLCO2B1 (Ki = 68.4 uM) | [2] | |||
Sodium lauryl sulfate | DIG Info | Solute carrier SLCO2B1 (Ki = 1.98 uM) | [2] | |||
FD&C blue no. 2 | DIG Info | Adenosine receptor A3 (IC50 = 1 uM) | [3] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Drug Formulation 2 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; Magnesium stearate; Calcium sulfate; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Triacetin; Carnauba wax; Ethylcelluloses; Hypromelloses; Polyethylene glycols; Shellac
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Dosage Form | 12 HR Extended Release Oral Tablet | |||||
Company | DAVA Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Stearic acid | DIG Info | Phosphodiesterase 3A (IC50 = 3.1 uM) | [3] | |||
Propylene glycol | DIG Info | Albendazole monooxygenase (Inhibition ratio < 20 %) | [4] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Salbutamol 2 mg tablet | Click to Show/Hide the Full List of Formulation(s): 3 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Mylan Pharamceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Sodium lauryl sulfate | DIG Info | Solute carrier SLCO2B1 (Ki = 1.98 uM) | [2] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Drug Formulation 2 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Sodium starch glycolate type a potato; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Physicians Total Care; RemedyRepack | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Drug Formulation 3 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Sodium starch glycolate type a potato; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | RemedyRepack | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
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