Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00702)
Name
Trientine
Synonyms    Click to Show/Hide the Synonyms of This API
TRIETHYLENETETRAMINE; trientine; 112-24-3; 1,2-Ethanediamine, N,N'-bis(2-aminoethyl)-; Triethylene tetramine; Araldite hardener HY 951; DEH 24; Araldite HY 951; 1,4,7,10-Tetraazadecane; 1,8-Diamino-3,6-diazaoctane; N,N'-Bis(2-aminoethyl)-1,2-ethanediamine; Syprine; 3,6-Diazaoctane-1,8-diamine; N,N'-Bis(2-aminoethyl)ethylenediamine; NSC 443; UNII-SJ76Y07H5F; HY 951; MFCD00008169; triethylenetetraamine; 2,2,2-tetramine; Ethylenediamine, N,N'-bis(2-aminoethyl)-; N,N'-bis(2-aminoethyl)ethane-1,2-diamine; CHEMBL609; N'-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine; 3,6-Diazaoctanethylenediamin; SJ76Y07H5F; CHEBI:39501; NSC-443; 1,2-Ethanediamine, N1,N2-bis(2-aminoethyl)-; (2-aminoethyl)({2-[(2-aminoethyl)amino]ethyl})amine; NCGC00091695-01; NCGC00091695-03; DSSTox_CID_3702; Triethylenetetramine, 60%; DSSTox_RID_77156; DSSTox_GSID_23702; N1,N1'-(Ethane-1,2-diyl)diethane-1,2-diamine; Trientinum; Trientina; Trientinum [INN-Latin]; Trientina [INN-Spanish]; CAS-112-24-3; CCRIS 6279; HSDB 1002; (2-aminoethyl){2-[(2-aminoethyl)amino]ethyl}amine; EINECS 203-950-6; UN2259; BRN 0605448; triene; Trientene; N,N-Bis(2-aminoethyl)-1,2-diaminoethane; AI3-24384; 1,6-diazaoctane; EPH 925; Trientine [INN]; 3,8-diamine; Tomography, x-ray computed trientine; triethylene tetraamine; 1,7,10-Tetraazadecane; bmse000773; Texlin 300 (Salt/Mix); ACMC-1C99K; SCHEMBL15439; WLN: Z2M2M2Z; 4-04-00-01242 (Beilstein Handbook Reference); BIDD:ER0303; BIDD:GT0014; NSC443; SCHEMBL6423840; DTXSID9023702; STR03562; Tox21_111162; Tox21_201066; ANW-16423; BDBM50323751; SBB058767; STL477736; ZINC19364225; N,N'-Di(2-aminoethyl)ethylenediamine; AKOS006223906; Tox21_111162_1; Triethylenetetramine, >=97.0% (T); DB06824; Ethylenediamine,N'-bis(2-aminoethyl)-; MCULE-3203769500; NCGC00091695-04; NCGC00258619-01; BP-30180; Ethanediamine, N,N'-bis(2-aminoethyl)-; SBI-0206814.P001; DB-041060; N,N'-Bis(2-aminoethyl)-1,2-diaminoethane; Triethylenetetramine, technical grade, 60%; ST50824040; Triethylenetetramine [UN2259] [Corrosive]; 12T243; C07166; AB00573244_07; N,N''-Bis-(2-amino-ethyl)-ethane-1,2-diamine; 133105-EP2272849A1; 133105-EP2295438A1; Q418386; J-018026; N,N''-BIS(2-AMINOETHYL)-1,2-ETHANEDIAMINE; W-109064; 105821-86-1
Clinical Status
Approved
Disease Indication Hyperphosphatemia ICD-11: 5C64 [1]
PubChem CID
5565
Formula
C6H18N4
Canonical SMILES
C(CNCCNCCN)N
InChI
1S/C6H18N4/c7-1-3-9-5-6-10-4-2-8/h9-10H,1-8H2
InChIKey
VILCJCGEZXAXTO-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5565"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 146.23 Topological Polar Surface Area 76.1
XlogP -2.5 Complexity 49.7
Heavy Atom Count 10 Rotatable Bond Count 7
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 4
Full List of Drug Formulations (DFMs) Containing This API
          Trientine 250 mg capsule Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Titanium dioxide; Gelatin
                   Dosage Form Oral Capsule
                   Company Aton Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Titanium dioxide; Gelatin
                   Dosage Form Oral Capsule
                   Company Valeant Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
          Trientine Hydrochloride 250mg capsule Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic Acid; Gelatin; Titanium Dioxide; Shellac; Titanium Dioxide; Fd&C Yellow 5 Aluminum Lake; Fd&C Blue 1 Aluminum Lake; Fd&C Blue 2/Indigo Carmine Aluminum Lake; Fd&C Blue 1/Brilliant Blue Fcf Aluminum Lake
                   Dosage Form Capsule
                   Company Kadmon Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Food blue 1 aluminum lake DIG Info Leukemia MT4 cells (IC50 = 1288.25 nM) [3]
Gelatin DIG Info Mephenytoin 4-hydroxylase (EC50 = 20.5 uM) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Gelatin; Iron Oxides; Stearic Acid; Titanium Dioxide
                   Dosage Form Capsule
                   Company Oceanside Pharmaceutials
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Gelatin DIG Info Mephenytoin 4-hydroxylase (EC50 = 20.5 uM) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Shellac; Propylene Glycol; Black Iron Oxide; Potassium Hydroxide
                   Dosage Form Capsule
                   Company Navinta
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [5]
References
1 FDA label for approved trientine from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Synthesis and structure-activity relationship studies of CD4 down-modulating cyclotriazadisulfonamide (CADA) analogues. J Med Chem. 2006 Feb 23; 49(4):1291-312.
4 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
5 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.

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