Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET0LX3S)
Name
Glutamate receptor (GRIA)
Family Transmembrane channel/porin (TC/P)  >>  Glutamate-gated ion channel (GIC)
Organism
Homo sapiens (Human)
UniProt ID GRIA1_HUMAN (click to find more protein-related data of this DBT)
GRIA2_HUMAN (click to find more protein-related data of this DBT)
GRIA3_HUMAN (click to find more protein-related data of this DBT)
GRIA4_HUMAN (click to find more protein-related data of this DBT)
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
          DIG Name: Glutamic acid hydrochloride Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Acidulant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 613 nM (estimated based on the structural similarity with CHEMBL575060 ) [1]
                   Structural Similarity Tanimoto coefficient = 1
                   Tested Species Homo sapiens (Human)
                   UniProt ID GRIA1_HUMAN ; GRIA2_HUMAN ; GRIA3_HUMAN ; GRIA4_HUMAN
          DIG Name: Monosodium glutamate Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Buffering agent; Flavoring agent
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 150 nM (estimated based on the structural similarity with CHEMBL575060 ) [2]
                   Structural Similarity Tanimoto coefficient = 0.979166667
                   Tested Species Rattus norvegicus (Rat)
                   UniProt ID GRIA1_RAT ; GRIA2_RAT ; GRIA3_RAT ; GRIA4_RAT
References
1 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization. J. Med. Chem. 2005; 48:6887-6896.
2 Syntheses of trans-3-substituted-CCG-IV analogs and their characterization to ionotropic glutamate receptors. Bioorg Med Chem Lett. (1996) 6:2381-2386.

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