Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0CZ9M)
DIG Name
Monosodium glutamate
Synonyms    Click to Show/Hide the Synonyms of This DIG
MONOSODIUM GLUTAMATE; 142-47-2; Sodium glutamate; Sodium L-glutamate; L-Glutamic acid, monosodium salt; Monosodium L-glutamate; L-Glutamic acid sodium salt; Glutamic acid, sodium salt; Ajinomoto; Glutacyl; Glutavene; L(+) Sodium glutamate; Glutamate monosodium salt; Sodium hydrogen glutamate; Natriumglutaminat; Glutamate Sodium; Natrium L-hydrogenglutamat; Monosodioglutammato; Glutammato monosodico; L-Glutamic Acid Monosodium; Vetsin; Zest; L-Glutamic acid Monosodium salt; Sodium (S)-2-amino-4-carboxybutanoate; Chinese seasoning; UNII-C3C196L9FG; sodium (2S)-2-amino-4-carboxybutanoate; Ancoma; Glutamic acid, monosodium salt; MSG; Accent (food additive); Glutamat sodny [Czech]; Glutamat sodny; Sodium glutamate (VAN); Natriumglutaminat [German]; C3C196L9FG; Sodium L-glutamate (VAN); 16177-21-2; Monosodioglutammato [Italian]; FEMA No. 2756; CCRIS 3625; HSDB 580; Glutammato monosodico [Italian]; l-Monosodium glutamate; Glutamic acid, L-, sodium salt; RL-50; Glutamate Sodium [JAN]; EINECS 205-538-1; L-Glutamic acid, sodium salt (VAN); NSC 135529; Monosodium glutamate anhydrous; AI3-18393; EINECS 240-313-1; Glutamic acid, monosodium salt, L-; L-Glutamic acid, sodiumsalt (1:1); H-Glu-OH.Na; sodium;(2S)-2-amino-5-hydroxy-5-oxopentanoate; L-Glutamic acid, sodium salt (1:1); 6106-04-3; EC 205-538-1; SCHEMBL16336; DTXSID9020906; AKOS027257231; sodium 2-amino-5-hydroxy-5-oxopentanoate; G0188; J-007661
DIG Function
Buffering agent; Flavoring agent
PubChem CID
23672308
Formula
C5H8NNaO4
Canonical SMILES
C(CC(=O)O)[C@@H](C(=O)[O-])N.[Na+]
InChI
1S/C5H9NO4.Na/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);/q;+1/p-1/t3-;/m0./s1
InChIKey
LPUQAYUQRXPFSQ-DFWYDOINSA-M
   Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=23672308"></iframe>
3D MOL is not available 2D MOL
Physicochemical Properties Molecular Weight 169.11 Topological Polar Surface Area 103
XlogP N.A. Complexity 149
Heavy Atom Count 11 Rotatable Bond Count 4
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 5
Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
      G-protein coupled receptor (GPCR)
            DBT Name: Glutamate receptor mGLU1 (mGluR1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity EC50 = 1050 nM (estimated based on the structural similarity with CHEMBL575060 ) [1]
                    Structural Similarity Tanimoto coefficient = 0.979166667
                    Tested Species Homo sapiens (Human)
                    UniProt ID GRM1_HUMAN
            DBT Name: Glutamate receptor mGLU2 (mGluR2) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity EC50 = 610 nM (estimated based on the structural similarity with CHEMBL575060 ) [2]
                    Structural Similarity Tanimoto coefficient = 0.979166667
                    Tested Species Rattus norvegicus (Rat)
                    UniProt ID GRM2_RAT
            DBT Name: Glutamate receptor mGLU3 (mGluR3) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity EC50 = 60 nM (estimated based on the structural similarity with CHEMBL575060 ) [3]
                    Structural Similarity Tanimoto coefficient = 0.979166667
                    Tested Species Homo sapiens (Human)
                    UniProt ID GRM3_HUMAN
               Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity EC50 = 57.54 nM (estimated based on the structural similarity with CHEMBL575060 ) [4]
                    Structural Similarity Tanimoto coefficient = 0.979166667
                    Tested Species Rattus norvegicus (Rat)
                    UniProt ID GRM3_RAT
            DBT Name: Glutamate receptor mGLU4 (mGluR4) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity EC50 = 3200 nM (estimated based on the structural similarity with CHEMBL575060 ) [3]
                    Structural Similarity Tanimoto coefficient = 0.979166667
                    Tested Species Homo sapiens (Human)
                    UniProt ID GRM4_HUMAN
               Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity EC50 = 2880 nM (estimated based on the structural similarity with CHEMBL575060 ) [5]
                    Structural Similarity Tanimoto coefficient = 0.979166667
                    Tested Species Rattus norvegicus (Rat)
                    UniProt ID GRM4_RAT
            DBT Name: Glutamate receptor mGLU5 (mGluR5) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity EC50 = 3100 nM (estimated based on the structural similarity with CHEMBL575060 ) [6]
                    Structural Similarity Tanimoto coefficient = 0.979166667
                    Tested Species Homo sapiens (Human)
                    UniProt ID GRM5_HUMAN
               Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity EC50 = 1200 nM (estimated based on the structural similarity with CHEMBL575060 ) [7]
                    Structural Similarity Tanimoto coefficient = 0.979166667
                    Tested Species Rattus norvegicus (Rat)
                    UniProt ID GRM5_RAT
            DBT Name: Glutamate receptor mGLU6 (mGluR6) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity EC50 = 7600 nM (estimated based on the structural similarity with CHEMBL575060 ) [7]
                    Structural Similarity Tanimoto coefficient = 0.979166667
                    Tested Species Rattus norvegicus (Rat)
                    UniProt ID GRM6_RAT
            DBT Name: Glutamate receptor mGLU7 (mGluR7) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity EC50 = 1180 nM (estimated based on the structural similarity with CHEMBL575060 ) [4]
                    Structural Similarity Tanimoto coefficient = 0.979166667
                    Tested Species Homo sapiens (Human)
                    UniProt ID GRM7_HUMAN
            DBT Name: Glutamate receptor mGLU8 (mGluR8) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity EC50 = 22 nM (estimated based on the structural similarity with CHEMBL575060 ) [8]
                    Structural Similarity Tanimoto coefficient = 0.979166667
                    Tested Species Mus musculus (Mouse)
                    UniProt ID GRM8_MOUSE
               Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity EC50 = 8000 nM (estimated based on the structural similarity with CHEMBL575060 ) [9]
                    Structural Similarity Tanimoto coefficient = 0.979166667
                    Tested Species Rattus norvegicus (Rat)
                    UniProt ID GRM8_RAT
      Transmembrane channel/porin (TC/P)
            DBT Name: GluA2-GluA3 complex (GRIA2-GRIA3) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity EC50 = 11000 nM (estimated based on the structural similarity with CHEMBL575060 ) [10]
                    Structural Similarity Tanimoto coefficient = 0.979166667
                    Tested Species Homo sapiens (Human)
                    UniProt ID GRIA2_HUMAN ; GRIA3_HUMAN
            DBT Name: Glutamate receptor AMPA 3 (GRIA3) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity EC50 = 3660 nM (estimated based on the structural similarity with CHEMBL575060 ) [10]
                    Structural Similarity Tanimoto coefficient = 0.979166667
                    Tested Species Homo sapiens (Human)
                    UniProt ID GRIA3_HUMAN
            DBT Name: Glutamate receptor AMPA 4 (GRIA4) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity Ki = 868 nM (estimated based on the structural similarity with CHEMBL575060 ) [11]
                    Structural Similarity Tanimoto coefficient = 0.979166667
                    Tested Species Homo sapiens (Human)
                    UniProt ID GRIA4_HUMAN
            DBT Name: Glutamate receptor AMPA 1 (GRIA1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity EC50 = 2260 nM (estimated based on the structural similarity with CHEMBL575060 ) [10]
                    Structural Similarity Tanimoto coefficient = 0.979166667
                    Tested Species Homo sapiens (Human)
                    UniProt ID GRIA1_HUMAN
            DBT Name: Glutamate receptor AMPA 2 (GRIA2) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity EC50 = 2190 nM (estimated based on the structural similarity with CHEMBL575060 ) [10]
                    Structural Similarity Tanimoto coefficient = 0.979166667
                    Tested Species Homo sapiens (Human)
                    UniProt ID GRIA2_HUMAN
            DBT Name: Glutamate receptor (GRIA) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 150 nM (estimated based on the structural similarity with CHEMBL575060 ) [12]
                    Structural Similarity Tanimoto coefficient = 0.979166667
                    Tested Species Rattus norvegicus (Rat)
                    UniProt ID GRIA1_RAT ; GRIA2_RAT ; GRIA3_RAT ; GRIA4_RAT
            DBT Name: Glutamate receptor kainate 1 (GRIK1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity EC50 = 22000 nM (estimated based on the structural similarity with CHEMBL575060 ) [13]
                    Structural Similarity Tanimoto coefficient = 0.979166667
                    Tested Species Homo sapiens (Human)
                    UniProt ID GRIK1_HUMAN
            DBT Name: Glutamate receptor kainate 2 (GRIK2) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity EC50 = 25000 nM (estimated based on the structural similarity with CHEMBL575060 ) [14]
                    Structural Similarity Tanimoto coefficient = 0.979166667
                    Tested Species Homo sapiens (Human)
                    UniProt ID GRIK2_HUMAN
References
1 First enantiospecific synthesis of a 3,4-dihydroxy-L-glutamic acid [(3S,4S)-DHGA], a new mGluR1 agonist. Bioorg Med Chem Lett. 2000 Jan 17; 10(2):129-33.
2 1-amino-APDC, a partial agonist of group II metabotropic glutamate receptors with neuroprotective properties. Bioorg Med Chem Lett. 1999 Jun 21; 9(12):1721-6.
3 A highly selective agonist for the metabotropic glutamate receptor mGluR2. Med Chem Comm. (2011) 2:1120-1124.
4 New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III. J Med Chem. 2016 Feb 11; 59(3):914-24.
5 -amino--fluorocyclopropanecarboxylic acids as a new tool for drug development: synthesis of glutamic acid analogs and agonist activity towards metabotropic glutamate receptor 4. Bioorg Med Chem. 2012 Aug 1; 20(15):4716-26.
6 Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist. J Med Chem. 1998 May 7; 41(10):1641-50.
7 Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines. Bioorg Med Chem. 2007 May 1; 15(9):3161-70.
8 Metabotropic glutamate receptors: novel targets for drug development. J Med Chem. 1995 Apr 28; 38(9):1417-26.
9 New probes of the agonist binding site of metabotropic glutamate receptors. Bioorg Med Chem Lett. 2001 Jun 18; 11(12):1569-72.
10 Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. Bioorg Med Chem. 2010 Feb 15; 18(4):1381-7.
11 4-Alkyl- and 4-cinnamylglutamic acid analogues are potent GluR5 kainate receptor agonists. J Med Chem. 2000 May 18; 43(10):1958-68.
12 Syntheses of trans-3-substituted-CCG-IV analogs and their characterization to ionotropic glutamate receptors. Bioorg Med Chem Lett. (1996) 6:2381-2386.
13 Structure-activity relationship studies on N3-substituted willardiine derivatives acting as AMPA or kainate receptor antagonists. J Med Chem. 2006 Apr 20; 49(8):2579-92.
14 4-Alkylidenyl glutamic acids, potent and selective GluR5 agonists. Bioorg Med Chem Lett. 2000 Aug 21; 10(16):1807-10.

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