General Information of DBT (ID: ET0UH9P)
Name
Hepatoblastoma HepG2 cells (HepG2)
Synonyms    Click to Show/Hide the Synonyms of This DBT
Human hepatoblastoma HepG2 cells; HEP-G2; Hep G2; HEP G2; HepG2; HEPG2
Family Cell line (CELL)  >>  Liver cell line (LIVcel)
Organism
Homo sapiens (Human)
Cellosaurus ID CVCL_0027 (click to find more cell line data of this DBT)
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
          DIG Name: Calcium ascorbate anhydrous Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Antioxidant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 > 100000 nM (estimated based on the structural similarity with CHEMBL196 ) [1]
                   Structural Similarity Tanimoto coefficient = 1
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0027
          DIG Name: D&C brown no. 1 Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Colorant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 28000 nM (estimated based on the structural similarity with CHEMBL3409815 ) [2]
                   Structural Similarity Tanimoto coefficient = 0.793103448
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0027
          DIG Name: methylparaben Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Antimicrobial preservative
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 > 20 ug.mL-1 (tested by experiment) [3]
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0027
          DIG Name: Methylchloroisothiazolinone Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Antimicrobial preservative
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 12000 nM (estimated based on the structural similarity with CHEMBL461475 ) [4]
                   Structural Similarity Tanimoto coefficient = 0.925
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0027
          DIG Name: Sodium desoxycholate Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Antioxidant; Surfactant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 > 100000 nM (estimated based on the structural similarity with CHEMBL406393 ) [5]
                   Structural Similarity Tanimoto coefficient = 1
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0027
References
1 Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives. Eur J Med Chem. 2019 Dec 15; 184:111739.
2 Synthesis, anticancer and radiosensitizing evaluation of some novel sulfonamide derivatives. Eur J Med Chem. 2015 Mar 6; 92:682-92.
3 Bioactive Phenolic Components from the Twigs of Atalantia buxifolia. J Nat Prod. 2018 Jul 27; 81(7):1534-1539.
4 Reactivity of isothiazolones and isothiazolone-1-oxides in the inhibition of the PCAF histone acetyltransferase. Eur J Med Chem. 2009 Dec; 44(12):4855-61.
5 Novel derivatives of deoxycholic acid bearing aliphatic or cyclic diamine moieties at the C-3 position: Synthesis and evaluation of anti-proliferative activity. Bioorg Med Chem Lett. 2017 Aug 15; 27(16):3755-3759.

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