Details of the Biological Target of DIG (DBT)
General Information of DBT (ID: ET0UH9P) | |||||
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Name |
Hepatoblastoma HepG2 cells (HepG2)
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Synonyms |
Click to Show/Hide the Synonyms of This DBT
Human hepatoblastoma HepG2 cells; HEP-G2; Hep G2; HEP G2; HepG2; HEPG2
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Family | Cell line (CELL) >> Liver cell line (LIVcel) | ||||
Organism |
Homo sapiens (Human)
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Cellosaurus ID | CVCL_0027 | (click to find more cell line data of this DBT) | |||
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT | ||||||
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DIG Name: Calcium ascorbate anhydrous | Click to Show/Hide | |||||
Detailed Information | DIG Info click to show the detail info of this DIG | |||||
Functional Class | Click to Show/Hide the Functional Class of This DIG
Antioxidant
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Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
Biological Activity | IC50 > 100000 nM (estimated based on the structural similarity with CHEMBL196 ) | [1] | ||||
Structural Similarity | Tanimoto coefficient = 1 | |||||
Tested Species | Homo sapiens (Human) | |||||
Cellosaurus ID | CVCL_0027 | |||||
DIG Name: D&C brown no. 1 | Click to Show/Hide | |||||
Detailed Information | DIG Info click to show the detail info of this DIG | |||||
Functional Class | Click to Show/Hide the Functional Class of This DIG
Colorant
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Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
Biological Activity | IC50 = 28000 nM (estimated based on the structural similarity with CHEMBL3409815 ) | [2] | ||||
Structural Similarity | Tanimoto coefficient = 0.793103448 | |||||
Tested Species | Homo sapiens (Human) | |||||
Cellosaurus ID | CVCL_0027 | |||||
DIG Name: methylparaben | Click to Show/Hide | |||||
Detailed Information | DIG Info click to show the detail info of this DIG | |||||
Functional Class | Click to Show/Hide the Functional Class of This DIG
Antimicrobial preservative
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Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
Biological Activity | IC50 > 20 ug.mL-1 (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
Cellosaurus ID | CVCL_0027 | |||||
DIG Name: Methylchloroisothiazolinone | Click to Show/Hide | |||||
Detailed Information | DIG Info click to show the detail info of this DIG | |||||
Functional Class | Click to Show/Hide the Functional Class of This DIG
Antimicrobial preservative
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Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
Biological Activity | IC50 = 12000 nM (estimated based on the structural similarity with CHEMBL461475 ) | [4] | ||||
Structural Similarity | Tanimoto coefficient = 0.925 | |||||
Tested Species | Homo sapiens (Human) | |||||
Cellosaurus ID | CVCL_0027 | |||||
DIG Name: Sodium desoxycholate | Click to Show/Hide | |||||
Detailed Information | DIG Info click to show the detail info of this DIG | |||||
Functional Class | Click to Show/Hide the Functional Class of This DIG
Antioxidant; Surfactant
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Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
Biological Activity | IC50 > 100000 nM (estimated based on the structural similarity with CHEMBL406393 ) | [5] | ||||
Structural Similarity | Tanimoto coefficient = 1 | |||||
Tested Species | Homo sapiens (Human) | |||||
Cellosaurus ID | CVCL_0027 | |||||
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