Details of the Drug Formulation (DFM)
| General Information of DFM (ID: F00930) | |||||
|---|---|---|---|---|---|
| Name |
Amantadine 100 mg capsule
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| Company |
RemedyRepack
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| Active Pharmaceutical Ingredient (API) | Amantadine |
API Info
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| Influenza virus infection | ICD-11: 1E30 | Approved | |||
| Drug Inactive Ingredient (DIGs) | |||||
| DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
| E0M0IE | DIG Info | Ferric hydroxide oxide yellow | Colorant | ||
| E02FBG | DIG Info | Ferrosoferric oxide | Colorant | ||
| E06WYP | DIG Info | Glycerin | Antimicrobial preservative ... | ||
| E04KSN | DIG Info | Hexahydric alcohol | Diluent ... | ||
| E0Q6DQ | DIG Info | Mannitol | Diluent ... | ||
| E05BSD | DIG Info | Titanium dioxide | Coating agent ... | ||
| Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
|---|---|---|---|---|---|---|
| Transmembrane channel/porin (TC/P) | ||||||
| DBT Name: Glycine receptor alpha-1 (GLRA1) | Click to Show/Hide | |||||
| Detailed Information |
DBT Info
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| Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Mannitol | |||||
| Biological Activity | EC50 = 12589.25 nM (estimated based on the structural similarity with CHEMBL604608 ) | [1] | ||||
| Structural Similarity | Tanimoto coefficient = 0.804878049 | |||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | GLRA1_HUMAN | |||||
| References | |||||
|---|---|---|---|---|---|
| 1 | Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective. Bioorg Med Chem Lett. 2017 Jun 1; 27(11):2239-2258. | ||||
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