Details of the Drug Formulation (DFM)
General Information of DFM (ID: F10997) | |||||
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Name |
Labetalol 200 mg tablet
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Company |
County Line Pharmaceuticals
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Active Pharmaceutical Ingredient (API) | Labetalol | API Info click to show the detail info of this API | |||
Essential hypertension | ICD-11: BA00 | Approved | |||
Drug Inactive Ingredient (DIGs) | |||||
DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
E0SJ4H | DIG Info | Beta-D-lactose | Diluent ... | ||
E01UTP | DIG Info | Magnesium stearate | lubricant | ||
E0Y7PW | DIG Info | Sodium benzoate | Antimicrobial preservative ... | ||
E05BSD | DIG Info | Titanium dioxide | Coating agent ... | ||
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
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Oxidoreductase (ORase) | ||||||
DBT Name: Albendazole monooxygenase (CYP3A4) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Magnesium stearate | |||||
Biological Activity | Protein expression downregulation (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Lyase/isomerase/ligase (L/I/G) | ||||||
DBT Name: Carbonic anhydrase II (CA2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Sodium benzoate | |||||
Biological Activity | Ki = 30000 nM (tested by experiment) | [2] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CAH2_HUMAN | |||||
DBT Name: Carbonic anhydrase IV (CA4) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Sodium benzoate | |||||
Biological Activity | Ki = 74700 nM (tested by experiment) | [2] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CAH4_HUMAN | |||||
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