Details of the Drug Formulation (DFM)
General Information of DFM (ID: F14018) | |||||
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Name |
Metyrapone 250 mg capsule
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Company |
Laboratoire HRA Pharma
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Active Pharmaceutical Ingredient (API) | Metyrapone | API Info click to show the detail info of this API | |||
Cushing syndrome | ICD-11: 5A70 | Approved | |||
Drug Inactive Ingredient (DIGs) | |||||
DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
E01EBV | DIG Info | Ethyl vanillin | Flavoring agent | ||
E06WYP | DIG Info | Glycerin | Antimicrobial preservative ... | ||
E0X6QO | DIG Info | Propylparaben sodium | Antimicrobial preservative | ||
E05BSD | DIG Info | Titanium dioxide | Coating agent ... | ||
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
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Oxidoreductase (ORase) | ||||||
DBT Name: Aldehyde dehydrogenase 5A1 (ALDH5A1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Ethyl vanillin | |||||
Biological Activity | IC50 = 15600 nM (estimated based on the structural similarity with CHEMBL13883 ) | [1] | ||||
Structural Similarity | Tanimoto coefficient = 0.975806452 | |||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | SSDH_HUMAN | |||||
Nuclear receptor (NR) | ||||||
DBT Name: Estrogen receptor alpha (ESR1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Propylparaben sodium | |||||
Biological Activity | EC50 = 38200 nM (estimated based on the structural similarity with CHEMBL15841 ) | [2] | ||||
Structural Similarity | Tanimoto coefficient = 0.946428571 | |||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | ESR1_HUMAN | |||||
Cell line (CELL) | ||||||
DBT Name: Lung cancer A-549 cells (A-549) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Ethyl vanillin | |||||
Biological Activity | IC50 = 16.42 ug.mL-1 (estimated based on the structural similarity with CHEMBL13883 ) | [3] | ||||
Structural Similarity | Tanimoto coefficient = 0.975806452 | |||||
Tested Species | Homo sapiens (Human) | |||||
Cellosaurus ID | CVCL_0023 | |||||
DBT Name: Breast cancer MCF7 cells (MCF7) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Ethyl vanillin | |||||
Biological Activity | IC50 = 15.69 ug.mL-1 (estimated based on the structural similarity with CHEMBL13883 ) | [3] | ||||
Structural Similarity | Tanimoto coefficient = 0.975806452 | |||||
Tested Species | Homo sapiens (Human) | |||||
Cellosaurus ID | CVCL_0031 | |||||
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