Details of the Drug Formulation (DFM)

General Information of DFM (ID: F14084)
Name
Minocycline 100 mg capsule
Company
Aidarex Pharmaceuticals; Bryant Ranch Prepack; Clinical Solutions Wholesale; Kaiser Foundation Hospitals; Lake Eire Medical & Surgical Supply DBA Quality Care Products; Liberty Pharmaceuticals; Physicians Total Care; Proficient Rx; Ranbaxy Pharmaceuticals; RemedyRepack
Active Pharmaceutical Ingredient (API) Minocycline API Info click to show the detail info of this API
Streptococcus bacterial infection ICD-11: 1C41 Approved
Drug Inactive Ingredient (DIGs)
DIG ID DIG Info DIG Name DIG Functional Class
E02FBG DIG Info Ferrosoferric oxide Colorant
E01UTP DIG Info Magnesium stearate lubricant
E0ND5Z DIG Info Potassium hydroxide Alkalizing agent
E0M1JK DIG Info Propylene glycol Antimicrobial preservative ...
E05BSD DIG Info Titanium dioxide Coating agent ...
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
      Oxidoreductase (ORase)
            DBT Name: Albendazole monooxygenase (CYP3A4) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Propylene glycol
                    Biological Activity Inhibition ratio < 20 % (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP3A4_HUMAN
               Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Magnesium stearate
                    Biological Activity Protein expression downregulation (tested by experiment) [2]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP3A4_HUMAN
References
1 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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