Details of the Drug Formulation (DFM)
General Information of DFM (ID: F16794) | |||||
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Name |
Pentoxifylline 400 mg tablet
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Company |
Aphena Pharma Solutions-Tennessee; Oceanside Pharmaceuticals
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Active Pharmaceutical Ingredient (API) | Pentoxifylline | API Info click to show the detail info of this API | |||
Intermittent claudication | ICD-11: BD40 | Approved | |||
Drug Inactive Ingredient (DIGs) | |||||
DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
E0N2PK | DIG Info | Isopropyl alcohol | Antimicrobial preservative ... | ||
E01UTP | DIG Info | Magnesium stearate | lubricant | ||
E0QY1F | DIG Info | Talc | Anticaking agent ... | ||
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
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Oxidoreductase (ORase) | ||||||
DBT Name: Albendazole monooxygenase (CYP3A4) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Magnesium stearate | |||||
Biological Activity | Protein expression downregulation (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Cell line (CELL) | ||||||
DBT Name: Lymphoma P388/ADR cells (P388/ADR) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Isopropyl alcohol | |||||
Biological Activity | IC50 = 0.22 uM (estimated based on the structural similarity with CHEMBL545 ) | [2] | ||||
Structural Similarity | Tanimoto coefficient = 0.789473684 | |||||
Tested Species | Mus musculus (Mouse) | |||||
Cellosaurus ID | CVCL_IZ75 | |||||
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