General Information of DFM (ID: F18612)
Name	Quinapril 20 mg tablet
Company	American Health Packaging
Active Pharmaceutical Ingredient (API)	Quinapril		API Info click to show the detail info of this API
	Essential hypertension		ICD-11: BA00	Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0M0IE	DIG Info	Ferric hydroxide oxide yellow	Colorant
	E04NDE	DIG Info	Magnesium carbonate	Adsorbent ...
	E01UTP	DIG Info	Magnesium stearate	lubricant
	E0HR5F	DIG Info	Soybean lecithin	Other agent
	E0QY1F	DIG Info	Talc	Anticaking agent ...
	E05BSD	DIG Info	Titanium dioxide	Coating agent ...

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Oxidoreductase (ORase)
DBT Name: Albendazole monooxygenase (CYP3A4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Magnesium stearate
Biological Activity	Protein expression downregulation (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Soybean lecithin
Biological Activity	IC50 = 6.61 mg.mL-1 (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN

References
1	Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
2	Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.

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