Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0HR5F)
DIG Name	Soybean lecithin
DIG Function	Other agent

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 01		Infectious/parasitic disease	Click to Show/Hide
Azithromycin	API Info	Congenital syphilis [ICD-11: 1A60]		[1]
Amantadine	API Info	Influenza virus infection [ICD-11: 1E30]		[2]
Tetracycline	API Info	Spotted fever [ICD-11: 1C31]		[3]
Maraviroc	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[4]
Zidovudine	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[5]
Ganciclovir	API Info	Cytomegalovirus infection [ICD-11: 1D82]		[6]
Fidaxomicin	API Info	Clostridium difficile infection [ICD-11: 1A04]		[7]
Moxifloxacin	API Info	Streptococcus bacterial infection [ICD-11: 1C41]		[8]
ICD Disease Classification 02		Benign/in-situ/malignant neoplasm	Click to Show/Hide
Nicotinic acid	API Info	Lung cancer [ICD-11: 2C25]		[9]
Regorafenib	API Info	Colon cancer [ICD-11: 2B90]		[10]
ICD Disease Classification 05		Endocrine/nutritional/metabolic disease	Click to Show/Hide
Fenofibrate	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[11]
Atorvastatin	API Info	Hyperlipidaemia [ICD-11: 5C8Z]		[12]
Paricalcitol	API Info	Hyperparathyroidism [ICD-11: 5A51]		[13]
Metformin	API Info	Diabetes mellitus [ICD-11: 5A10]		[14]
Omega-3 acid ethyl ester	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[15]
Ergocalciferol	API Info	Hypoparathyroidism [ICD-11: 5A50]		[16]
Fluvastatin	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[17]
ICD Disease Classification 06		Mental/behavioural/neurodevelopmental disorder	Click to Show/Hide
Bupropion	API Info	Nicotine dependence [ICD-11: 6C4A]		[18]
Fluoxetine	API Info	Major depressive disorder [ICD-11: 6A70]		[19]
Venlafaxine	API Info	Major depressive disorder [ICD-11: 6A70]		[20]
Amitriptyline	API Info	Major depressive disorder [ICD-11: 6A70]		[21]
Methylphenidate	API Info	Attention deficit hyperactivity disorder [ICD-11: 6A05]		[22]
Paroxetine	API Info	Major depressive disorder [ICD-11: 6A70]		[23]
Quetiapine	API Info	Schizophrenia [ICD-11: 6A20]		[24]
Cyclobenzaprine	API Info	Major depressive disorder [ICD-11: 6A70]		[25]
Fluphenazine	API Info	Schizophrenia [ICD-11: 6A20]		[26]
Chlordiazepoxide	API Info	Anxiety disorder [ICD-11: 6B00]		[27]
ICD Disease Classification 08		Nervous system disease	Click to Show/Hide
Gabapentin	API Info	Focal seizure [ICD-11: 8A68]		[28]
Valproic acid	API Info	Epilepsy [ICD-11: 8A60]		[29]
Pramipexole	API Info	Parkinsonism [ICD-11: 8A00]		[30]
Ropinirole	API Info	Parkinsonism [ICD-11: 8A00]		[31]
Levetiracetam	API Info	Focal seizure [ICD-11: 8A68]		[32]
Topiramate	API Info	Focal seizure [ICD-11: 8A68]		[33]
Oxcarbazepine	API Info	Epilepsy [ICD-11: 8A60]		[34]
Donepezil	API Info	Alzheimer disease [ICD-11: 8A20]		[35]
Eletriptan	API Info	Migraine [ICD-11: 8A80]		[36]
Lacosamide	API Info	Epilepsy [ICD-11: 8A60]		[37]
Ezogabine	API Info	Epilepsy [ICD-11: 8A60]		[38]
ICD Disease Classification 10		Ear/mastoid process disease	Click to Show/Hide
Diphenhydramine	API Info	Meniere disease [ICD-11: AB31]		[39]
Amoxicillin	API Info	Acute otitis media [ICD-11: AB00]		[40]
ICD Disease Classification 11		Circulatory system disease	Click to Show/Hide
Nifedipine	API Info	Angina pectoris [ICD-11: BA40]		[41]
Propafenone	API Info	Ventricular tachyarrhythmia [ICD-11: BC71]		[42]
Benazepril	API Info	Essential hypertension [ICD-11: BA00]		[43]
Dipyridamole	API Info	Atherosclerosis [ICD-11: BA80]		[44]
Ambrisentan	API Info	Pulmonary hypertension [ICD-11: BB01]		[45]
Quinapril	API Info	Essential hypertension [ICD-11: BA00]		[46]
Macitentan	API Info	Pulmonary hypertension [ICD-11: BB01]		[47]
ICD Disease Classification 12		Respiratory system disease	Click to Show/Hide
Montelukast	API Info	Asthma [ICD-11: CA23]		[48]
Guaifenesin	API Info	Asthma [ICD-11: CA23]		[49]
Budesonide	API Info	Allergic rhinitis [ICD-11: CA08]		[50]
ICD Disease Classification 13		Digestive system disease	Click to Show/Hide
Pantoprazole	API Info	Gastro-oesophageal reflux disease [ICD-11: DA22]		[51]
Simethicone	API Info	Irritable bowel syndrome [ICD-11: DD91]		[52]
Mycophenolate mofetil	API Info	Crohn disease [ICD-11: DD70]		[53]
Cimetidine	API Info	Duodenal ulcer [ICD-11: DA63]		[54]
Rabeprazole	API Info	Gastro-oesophageal reflux disease [ICD-11: DA22]		[55]
Famotidine	API Info	Peptic ulcer [ICD-11: DA61]		[56]
Trimethobenzamide	API Info	Functional nausea/vomiting [ICD-11: DD90]		[57]
Nitazoxanide	API Info	Irritable bowel syndrome [ICD-11: DD91]		[58]
ICD Disease Classification 14		Skin disease	Click to Show/Hide
Pseudoephedrine	API Info	Erythema multiforme [ICD-11: EB12]		[59]
Tretinoin	API Info	Acne vulgaris [ICD-11: ED80]		[60]
ICD Disease Classification 15		Musculoskeletal/connective-tissue disease	Click to Show/Hide
Indomethacin	API Info	Rheumatoid arthritis [ICD-11: FA20]		[61]
Phenylephrine	API Info	Juvenile rheumatoid arthritis [ICD-11: FA24]		[62]
Piroxicam	API Info	Rheumatoid arthritis [ICD-11: FA20]		[63]
ICD Disease Classification 16		Genitourinary system disease	Click to Show/Hide
Ibuprofen	API Info	Dysmenorrhea [ICD-11: GA34]		[64]
Dutasteride	API Info	Prostatic hyperplasia [ICD-11: GA90]		[65]
Progesterone	API Info	Endometrial hyperplasia [ICD-11: GA16]		[66]
Sevelamer	API Info	Chronic kidney disease [ICD-11: GB61]		[67]
Fesoterodine	API Info	Overactive bladder [ICD-11: GC50]		[68]

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
Oxidoreductase (ORase)
DBT Name: Albendazole monooxygenase (CYP3A4)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 6.61 mg.mL-1 (tested by experiment)		[69]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN

References
1	FDA label for approved azithromycin from the official website of the U.S. Food and Drug Administration.
2	FDA label for approved amantadine from the official website of the U.S. Food and Drug Administration.
3	FDA label for approved tetracycline from the official website of the U.S. Food and Drug Administration.
4	FDA label for approved maraviroc from the official website of the U.S. Food and Drug Administration.
5	FDA label for approved zidovudine from the official website of the U.S. Food and Drug Administration.
6	FDA label for approved ganciclovir from the official website of the U.S. Food and Drug Administration.
7	FDA label for approved fidaxomicin from the official website of the U.S. Food and Drug Administration.
8	FDA label for approved moxifloxacin from the official website of the U.S. Food and Drug Administration.
9	FDA label for approved nicotinic acid from the official website of the U.S. Food and Drug Administration.
10	FDA label for approved regorafenib from the official website of the U.S. Food and Drug Administration.
11	FDA label for approved fenofibrate from the official website of the U.S. Food and Drug Administration.
12	FDA label for approved atorvastatin from the official website of the U.S. Food and Drug Administration.
13	FDA label for approved paricalcitol from the official website of the U.S. Food and Drug Administration.
14	FDA label for approved metformin from the official website of the U.S. Food and Drug Administration.
15	FDA label for approved omega-3 acid ethyl ester from the official website of the U.S. Food and Drug Administration.
16	FDA label for approved ergocalciferol from the official website of the U.S. Food and Drug Administration.
17	FDA label for approved fluvastatin from the official website of the U.S. Food and Drug Administration.
18	FDA label for approved bupropion from the official website of the U.S. Food and Drug Administration.
19	FDA label for approved fluoxetine from the official website of the U.S. Food and Drug Administration.
20	FDA label for approved venlafaxine from the official website of the U.S. Food and Drug Administration.
21	FDA label for approved amitriptyline from the official website of the U.S. Food and Drug Administration.
22	FDA label for approved methylphenidate from the official website of the U.S. Food and Drug Administration.
23	FDA label for approved paroxetine from the official website of the U.S. Food and Drug Administration.
24	FDA label for approved quetiapine from the official website of the U.S. Food and Drug Administration.
25	FDA label for approved cyclobenzaprine from the official website of the U.S. Food and Drug Administration.
26	FDA label for approved fluphenazine from the official website of the U.S. Food and Drug Administration.
27	FDA label for approved chlordiazepoxide from the official website of the U.S. Food and Drug Administration.
28	FDA label for approved gabapentin from the official website of the U.S. Food and Drug Administration.
29	FDA label for approved valproic acid from the official website of the U.S. Food and Drug Administration.
30	FDA label for approved pramipexole from the official website of the U.S. Food and Drug Administration.
31	FDA label for approved ropinirole from the official website of the U.S. Food and Drug Administration.
32	FDA label for approved levetiracetam from the official website of the U.S. Food and Drug Administration.
33	FDA label for approved topiramate from the official website of the U.S. Food and Drug Administration.
34	FDA label for approved oxcarbazepine from the official website of the U.S. Food and Drug Administration.
35	FDA label for approved donepezil from the official website of the U.S. Food and Drug Administration.
36	FDA label for approved eletriptan from the official website of the U.S. Food and Drug Administration.
37	FDA label for approved lacosamide from the official website of the U.S. Food and Drug Administration.
38	FDA label for approved ezogabine from the official website of the U.S. Food and Drug Administration.
39	FDA label for approved diphenhydramine from the official website of the U.S. Food and Drug Administration.
40	FDA label for approved amoxicillin from the official website of the U.S. Food and Drug Administration.
41	FDA label for approved nifedipine from the official website of the U.S. Food and Drug Administration.
42	FDA label for approved flecainide from the official website of the U.S. Food and Drug Administration.
43	FDA label for approved benazepril from the official website of the U.S. Food and Drug Administration.
44	FDA label for approved dipyridamole from the official website of the U.S. Food and Drug Administration.
45	FDA label for approved ambrisentan from the official website of the U.S. Food and Drug Administration.
46	FDA label for approved quinapril from the official website of the U.S. Food and Drug Administration.
47	FDA label for approved macitentan from the official website of the U.S. Food and Drug Administration.
48	FDA label for approved montelukast from the official website of the U.S. Food and Drug Administration.
49	FDA label for approved guaifenesin from the official website of the U.S. Food and Drug Administration.
50	FDA label for approved budesonide from the official website of the U.S. Food and Drug Administration.
51	FDA label for approved pantoprazole from the official website of the U.S. Food and Drug Administration.
52	FDA label for approved simethicone from the official website of the U.S. Food and Drug Administration.
53	FDA label for approved mycophenolate mofetil from the official website of the U.S. Food and Drug Administration.
54	FDA label for approved cimetidine from the official website of the U.S. Food and Drug Administration.
55	FDA label for approved rabeprazole from the official website of the U.S. Food and Drug Administration.
56	FDA label for approved famotidine from the official website of the U.S. Food and Drug Administration.
57	FDA label for approved trimethobenzamide from the official website of the U.S. Food and Drug Administration.
58	FDA label for approved nitazoxanide from the official website of the U.S. Food and Drug Administration.
59	A study of sustained action pseudoephedrine in allergic rhinitis. Ann Allergy. 1982 Feb;48(2):87-92.
60	FDA label for approved tretinoin from the official website of the U.S. Food and Drug Administration.
61	FDA label for approved indomethacin from the official website of the U.S. Food and Drug Administration.
62	FDA label for approved phenylephrine from the official website of the U.S. Food and Drug Administration.
63	FDA label for approved piroxicam from the official website of the U.S. Food and Drug Administration.
64	FDA label for approved ibuprofen from the official website of the U.S. Food and Drug Administration.
65	FDA label for approved dutasteride from the official website of the U.S. Food and Drug Administration.
66	FDA label for approved progesterone from the official website of the U.S. Food and Drug Administration.
67	FDA label for approved sevelamer from the official website of the U.S. Food and Drug Administration.
68	FDA label for approved fesoterodine from the official website of the U.S. Food and Drug Administration.
69	Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.

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