General Information of DFM (ID: F23143)
Name	Ecallantide 10mg/ml injectable
Company	Dyax Corp
Active Pharmaceutical Ingredient (API)	Ecallantide		API Info click to show the detail info of this API
				Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E06YUO	DIG Info	Disodium hydrogenorthophosphate	Buffering agent ...
	E02GBG	DIG Info	Potassium chloride	Tonicity agent
	E0V4HH	DIG Info	Potassium phosphate monobasic	Buffering agent
	E0T4TW	DIG Info	Sodium chloride	Diluent ...

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Hydrolase (HDase)
DBT Name: Intestinal alkaline phosphatase (IAP)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Potassium phosphate monobasic
Biological Activity	IC50 = 2410 nM (tested by experiment)					[1]
Tested Species	Bos taurus (Bovine)
UniProt ID	PPBI_BOVIN
Lyase/isomerase/ligase (L/I/G)
DBT Name: Carbonic anhydrase IV (CA4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Potassium chloride
Biological Activity	Ki = 90000 nM (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	CAH4_HUMAN

References
1	Synthesis, crystal structure and biological evaluation of some novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines. Eur J Med Chem. 2014 May 6; 78:167-77.
2	Characterization and anions inhibition studies of an -carbonic anhydrase from the teleost fish Dicentrarchus labrax. Bioorg Med Chem. 2011 Jan 15; 19(2):744-8.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.