Details of the Drug Inactive Ingredient (DIG) | ACDINA

General Information of DIG (ID: E02GBG)
DIG Name	Potassium chloride
Synonyms	Click to Show/Hide the Synonyms of This DIG potassium chloride; 7447-40-7; Enseal; Muriate of potash; Klotrix; Sylvite; Slow-K; Klor-Con; Chlorvescent; Kalitabs; Kaochlor; Potavescent; Kloren; Pfiklor; Rekawan; Chloropotassuril; Potassium chloride (KCl); KCl-retard Zyma; Klor-Lyte; K-Contin; Kay Ciel; Monopotassium chloride; Potassium monochloride; Kaon-Cl; Chloride of potash; K-Lor; Kay-EM; Kaliumchlorid; Emplets potassium chloride; Potassiumchloride; Kaon-Cl 10; Potassium chloride solution; KCL; MFCD00011360; UNII-660YQ98I10; Steropotassium; Acronitol; Kaliduron; Kaliglutol; Kalilente; Kaliolite; Miopotasio; Neobakasal; Durekal; Durules; Kadalex; Kalcorid; Kaleorid; Kalinorm; Kalipor; Kalipoz; Keylyte; Klorvess; Potasion; Potasol; Celeka; Enpott; Natural sylvite; Kato; Kalium Duriles; Kalium Durules; Kalium-Durettes; Rekawan Retard; Kalium Retard; Lento-Kalium; Peter-kal; Kalitrans Retard; Potassium muriate; Durules-K; Kalium-R; Kay-Ciel; Repone K; Diffu-K; K-Lease; Kalinor-Retard P; Kalium SR; Kaon Cl; Lento-K; Micro-K; Super K; Ultra K Chlor; Ultra-K-Chlor; KCL Retard; Potassium chloride, FCC grade; Addi-K; Cena-K; K-Care; K-Grad; K-Norm; Span-K; Clor-K-Zaf; Micro-K Extentcaps; Plus Kalium Retard; Potassium chloride, ACS reagent; Infalyte; Kayciel; Apo-K; CHEBI:32588; K Tab; K-Dur; K-Lyte Cl; K-Sol; K-Tab; Kay-Cee-L; Leo-K; Micro-Kalium Retard; Rum-K; Ten-K; Nu-K; Slow-K tablets; Kalinorm Depottab; Tripotassium trichloride; NSC-77368; 660YQ98I10; K-SR; Chlorid draselny [Czech]; Super K (salt); Micro-K LS; Kaon-Cl TABS; Kalium S.R.; Klor-Con M20; Chlorid draselny; Potassium Cl; Buffer Solution, pH 2.00; Buffer Solution, pH 9.00; Potassium chloride, ultra dry; Potassium chloride, extra pure; Klor-Con M10; Klor-Con M15; Potassium chloride (K3Cl3); Caswell No. 686; Kaon Cl-10; Micro-K 10; Epiklor; Kali muriaticum; Kali Chloratum; Kali Chloridum; Potassium chloride, for biochemistry; Potassium, Reference Standard Solution; potassium;chloride; Potassii Chloridum; Potassium chloride, 99+%, ACS reagent; Potassium chloride, 99+%, for analysis; Sylvite (KCl); Klotrix (TN); Klor-con (TN); CCRIS 1962; Klor-Con 10; K-10; HSDB 1252; Kaon-Cl (TN); K-dur (TN); Potassium Chloride 10meq in Plastic Container; Potassium chloride, 99.999%, (trace metal basis); Potassium thallium chloride (KTlCl); [KCl]; EINECS 231-211-8; NSC 77368; EPA Pesticide Chemical Code 013904; KCL (TN); Potassium Chloride in Plastic Container; K+10; Potassium chloride [USP:JAN]; Potassium chloride 30meq in plastic container; Potassium chloride 40meq in plastic container; Cl.K; K.Cl; potassium chloride salt; ACMC-1CUXX; Potassium Chloride,(S); Potassium chloride 20meq in plastic container; WLN: KA G; EC 231-211-8; Potassium chloride (KCl);; Buffer Solution, pH 1.01; K+8; ISA (ionic strength adjustment solution: 1 M KCl); INS NO.508; Potassium Chloride, Food Grade; CHEMBL1200731; DTXSID5021178; Potassium Chloride (FRU Grade); Buffer Concentrate, pH 10.01; Potassium chloride (JP17/USP); INS-508; Potassium chloride solution, 1 M; Potassium chloride solution, 20%; Potassium chloride, Optical Grade; Potassium chloride, LR, >=99%; AMY37139; CS-B1714; NSC77368; Potassium Chloride - Drilling Grade; Potassium chloride solution, 3.3 M; 1992AH; 8784AF; Potassium chloride, AR, >=99.5%; AKOS015902779; AKOS024438069; AKOS024457458; Potassium chloride 3M aqueous solution; Potassium chloride solution, 0.01 M; DB00761; Potassium chloride, 1M aqueous solution; Potassium chloride, BioXtra, >=99.0%; Potassium chloride, BP, Ph. Eur. grade; 14336-88-0; E508; Potassium chloride Biochemical Grade = 99%; B7289; E 508; E-508; FT-0645107; P1757; Potassium chloride, ACS reagent, >=99.0%; Potassium chloride, p.a., 99.0-100.5%; Potassium Chloride (Technical Grade, Type A); Potassium Chloride (Technical Grade, Type B); Potassium chloride, 99.997% (metals basis); D02060; Potassium chloride, BioUltra, >=99.5% (AT); Potassium chloride, ReagentPlus(R), >=99.0%; Potassium chloride solution, in H2O (saturated); Potassium chloride, 99.999% trace metals basis; Potassium chloride, SAJ first grade, >=99.0%; Potassium chloride, tested according to Ph.Eur.; Potassium chloride, Trace metals grade 99.99%; Potassium chloride, >=99.99% trace metals basis; Potassium chloride, 0.85M, Conductivity Standard; Potassium chloride, ACS reagent, 99.0-100.5%; Potassium chloride, JIS special grade, >=99.5%; Potassium chloride, Spectroscopy Grade, Ultrapure; Potassium chloride, USP special, 99.0-100.5%; Potassium chloride, Vetec(TM) reagent grade, 99%; Q184630; Potassium chloride, 0.005M, Conductivity Standard; Potassium chloride, 0.007M, Conductivity Standard; Potassium chloride, 0.010M, Conductivity Standard; Potassium chloride, 0.0145M, Conductivity Standard; Potassium chloride, 0.0375M, Conductivity Standard; Potassium chloride, 0.0765M, Conductivity Standard; Potassium chloride, 0.117M, Conductivity Standard; Potassium chloride, 0.159M, Conductivity Standard; Potassium chloride, 1M aqueous solution, RNAse free; Potassium chloride, puriss. p.a., >=99.5% (AT); Potassium chloride solution, BioUltra, ~3 M in H2O; Potassium chloride, 0.00017M, Conductivity Standard; Potassium chloride, 0.00068M, Conductivity Standard; Potassium chloride, for molecular biology, >=99.0%; Potassium chloride, ~0.000027M, Conductivity Standard; Potassium chloride, meets EP, USP testing specifications; UNII-HJT620308C component WCUXLLCKKVVCTQ-UHFFFAOYSA-M; ISA (ionic strength adjustment solution: 1 M KCl), 1 M KCl; Potassium chloride crystal optic disc, 13mm x 2mm, unpolished; Potassium chloride crystal optic disc, 25mm x 5mm, unpolished; Potassium chloride crystal optic disc, 32mm x 3mm, unpolished; Potassium chloride solution, standard, solution (volumetric), 1.0 M; Potassium chloride, BioUltra, for molecular biology, >=99.5% (AT); Potassium standard for AAS, ready-to-use, traceable to BAM, in H2O; Potassium chloride crystal optic disc, 13mm x 1mm, polished both sides; Potassium chloride crystal optic disc, 13mm x 2mm, polished both sides; Potassium chloride crystal optic disc, 22mm x 4mm, polished both sides; Potassium chloride crystal optic disc, 25mm x 2mm, polished both sides; Potassium chloride crystal optic disc, 25mm x 4mm, polished both sides; Potassium chloride crystal optic disc, 32mm x 3mm, polished both sides; Potassium chloride crystal optic disc, 38mm x 6mm, polished both sides; Potassium chloride crystal optic rectangle, 30mm x 15mm x 4mm, unpolished; Potassium chloride crystal optic rectangle, 41mm x 23mm x 6mm, unpolished; Potassium chloride solution, BioUltra, for molecular biology, ~1 M in H2O; Potassium chloride, anhydrous, beads, -10 mesh, 99.99% trace metals basis; Potassium chloride, NIST SRM 1655, KCl (cr) for solution calorimetry; Potassium chloride, United States Pharmacopeia (USP) Reference Standard; Potassium chloride crystal optic disc, 32mm x 3mm (drilled), polished both sides; Potassium chloride crystal optic rectangle, 30mm x 15mm x 4mm, polished both sides; Potassium chloride crystal optic rectangle, 38.5mm x 19.5mm x 4mm, unpolished; Potassium chloride solution, 0.075 M, sterile-filtered, BioXtra, suitable for cell culture; Potassium chloride solution, conductance standard A acc. to ISO 7888, 0.1 M KCl; Potassium chloride solution, conductance standard B acc. to ISO 7888, 0.01 M KCl; Potassium chloride solution, conductance standard C acc. to ISO 7888, 0.001 M KCl; Potassium chloride solution, conductivity 11.67 mS/cm at 20 C, analytical standard; Potassium chloride, anhydrous, beads, -10 mesh, 99.999% trace metals basis; Potassium chloride, anhydrous, free-flowing, Redi-Dri(TM), ACS reagent, >=99%; Potassium chloride, anhydrous, free-flowing, Redi-Dri(TM), ReagentPlus(R), >=99%; Potassium Chloride, Pharmaceutical Secondary Standard; Certified Reference Material; Potassium chloride, puriss. p.a., reag. ISO, reag. Ph. Eur., 99.5-100.5%; Potassium atomic spectroscopy standard concentrate 1.00 g K, for 1 l standard solution, 1.00 g/L, analytical standard; Potassium atomic spectroscopy standard concentrate 10.00 g K, 10.00 g/L, for 1L standard solution, analytical standard; Potassium chloride crystal optic rectangle, 30mm x 15mm x 4mm, (drilled), polished both sides; Potassium chloride crystal optic rectangle, 38.5mm x 19.5mm x 4mm, (drilled), polished both sides; Potassium chloride, powder, BioReagent, suitable for cell culture, suitable for insect cell culture, >=99.0%; Potassium chloride, puriss., meets analytical specification of Ph. Eur., BP, USP, FCC, E508, 99-100.5% (AT), <=0.0001% Al; Potassium standard solution, suitable for atomic absorption spectrometry, 1000 ppm K+, 1 mg/mL K+
DIG Function	Tonicity agent
PubChem CID	4873
Formula	ClK
Canonical SMILES	[Cl-].[K+]
InChI	1S/ClH.K/h1H;/q;+1/p-1
InChIKey	WCUXLLCKKVVCTQ-UHFFFAOYSA-M
	Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=4873"></iframe>
Structure	3D MOL is not available			2D MOL
Physicochemical Properties	Molecular Weight		74.55	Topological Polar Surface Area	0
	XlogP		N.A.	Complexity	2
	Heavy Atom Count		2	Rotatable Bond Count	0
	Hydrogen Bond Donor Count		0	Hydrogen Bond Acceptor Count	1

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 02			Benign/in-situ/malignant neoplasm		Click to Show/Hide
Propoxyphene		API Info	Lung cancer [ICD-11: 2C25]			[1]
Alectinib		API Info	Lung cancer [ICD-11: 2C25]			[2]
ICD Disease Classification 06			Mental/behavioural/neurodevelopmental disorder		Click to Show/Hide
Bupropion		API Info	Nicotine dependence [ICD-11: 6C4A]			[3]
Clorazepate		API Info	Anxiety disorder [ICD-11: 6B00]			[4]
ICD Disease Classification 11			Circulatory system disease		Click to Show/Hide
Nifedipine		API Info	Angina pectoris [ICD-11: BA40]			[5]
Dabigatran etexilate		API Info	Venous thromboembolism [ICD-11: BD72]			[6]
ICD Disease Classification 13			Digestive system disease		Click to Show/Hide
Omeprazole		API Info	Gastro-oesophageal reflux disease [ICD-11: DA22]			[7]
Lansoprazole		API Info	Duodenal ulcer [ICD-11: DA63]			[8]
Rabeprazole		API Info	Gastro-oesophageal reflux disease [ICD-11: DA22]			[9]
Dexlansoprazole		API Info	Gastro-oesophageal reflux disease [ICD-11: DA22]			[10]
ICD Disease Classification 15			Musculoskeletal/connective-tissue disease		Click to Show/Hide
Flurbiprofen		API Info	Rheumatoid arthritis [ICD-11: FA20]			[11]

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
Lyase/isomerase/ligase (L/I/G)
DBT Name: Carbonic anhydrase IV (CA4)			Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Ki = 90000 nM (tested by experiment)				[12]
Tested Species	Homo sapiens (Human)
UniProt ID	CAH4_HUMAN

References
1	FDA label for approved propoxyphene from the official website of the U.S. Food and Drug Administration.
2	FDA label for approved alectinib from the official website of the U.S. Food and Drug Administration.
3	FDA label for approved bupropion from the official website of the U.S. Food and Drug Administration.
4	FDA label for approved clorazepate from the official website of the U.S. Food and Drug Administration.
5	FDA label for approved nifedipine from the official website of the U.S. Food and Drug Administration.
6	FDA label for approved dabigatran etexilate from the official website of the U.S. Food and Drug Administration.
7	FDA label for approved omeprazole from the official website of the U.S. Food and Drug Administration.
8	FDA label for approved lansoprazole from the official website of the U.S. Food and Drug Administration.
9	FDA label for approved rabeprazole from the official website of the U.S. Food and Drug Administration.
10	FDA label for approved dexlansoprazole from the official website of the U.S. Food and Drug Administration.
11	FDA label for approved flurbiprofen from the official website of the U.S. Food and Drug Administration.
12	Characterization and anions inhibition studies of an -carbonic anhydrase from the teleost fish Dicentrarchus labrax. Bioorg Med Chem. 2011 Jan 15; 19(2):744-8.

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