General Information of DFM (ID: F23316)
Name	Trifarotene 0.005% cream
Company	Galderma Laboratories
Active Pharmaceutical Ingredient (API)	Trifarotene		API Info click to show the detail info of this API
				Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0Q2ZN	DIG Info	Allantoin	Emollient
	E0ZJ4T	DIG Info	Cyclomethicone	Emollient ...
	E0SF4Y	DIG Info	Ethanol	Antimicrobial preservative ...
	E0X2OX	DIG Info	Medium-chain triglyceride	Emollient ...
	E0I5TO	DIG Info	Phenoxyethanol	Antimicrobial preservative
	E0M1JK	DIG Info	Propylene glycol	Antimicrobial preservative ...
	E0H2SC	DIG Info	Water	Solvent

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Oxidoreductase (ORase)
DBT Name: Albendazole monooxygenase (CYP3A4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Propylene glycol
Biological Activity	Inhibition ratio < 20 % (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
Cell line (CELL)
DBT Name: Colon cancer Caco-2 cells (Caco-2)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Medium-chain triglyceride
Biological Activity	Inhibition ratio > 36 % (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)

References
1	Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
2	Interactions between human multidrug resistance related protein (MRP2; ABCC2) and excipients commonly used in self-emulsifying drug delivery systems (SEDDS). Int J Pharm. 2013 Apr 15;447(1-2):192-8.

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