Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0X2OX)
DIG Name	Medium-chain triglyceride
DIG Function	Emollient; Lubricant; Surfactant

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 01		Infectious/parasitic disease	Click to Show/Hide
Raltegravir	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[1]
ICD Disease Classification 04		Immune system disease	Click to Show/Hide
Cetirizine	API Info	Allergy [ICD-11: 4A80]		[2]
ICD Disease Classification 05		Endocrine/nutritional/metabolic disease	Click to Show/Hide
Paricalcitol	API Info	Hyperparathyroidism [ICD-11: 5A51]		[3]
Ergocalciferol	API Info	Hypoparathyroidism [ICD-11: 5A50]		[4]
Doxercalciferol	API Info	Hyperparathyroidism [ICD-11: 5A51]		[5]
Calcifediol	API Info	Vitamin deficiency [ICD-11: 5B55]		[6]
ICD Disease Classification 06		Mental/behavioural/neurodevelopmental disorder	Click to Show/Hide
Venlafaxine	API Info	Major depressive disorder [ICD-11: 6A70]		[7]
Methylphenidate	API Info	Attention deficit hyperactivity disorder [ICD-11: 6A05]		[8]
Guanfacine	API Info	Attention deficit hyperactivity disorder [ICD-11: 6A05]		[9]
ICD Disease Classification 07		Sleep-wake disorder	Click to Show/Hide
Dextroamphetamine	API Info	Narcolepsy [ICD-11: 7A20]		[10]
ICD Disease Classification 08		Nervous system disease	Click to Show/Hide
Acetaminophen	API Info	Anaesthesia [ICD-11: 8E22]		[11]
Levetiracetam	API Info	Focal seizure [ICD-11: 8A68]		[12]
Carbamazepine	API Info	Epilepsy [ICD-11: 8A60]		[13]
Topiramate	API Info	Focal seizure [ICD-11: 8A68]		[14]
ICD Disease Classification 09		Visual system disease	Click to Show/Hide
Dextromethorphan	API Info	Allergic conjunctivitis [ICD-11: 9A60]		[15]
Acetazolamide	API Info	Glaucoma [ICD-11: 9C61]		[16]
ICD Disease Classification 10		Ear/mastoid process disease	Click to Show/Hide
Diphenhydramine	API Info	Meniere disease [ICD-11: AB31]		[17]
ICD Disease Classification 11		Circulatory system disease	Click to Show/Hide
Nimodipine	API Info	Cerebral vasospasm [ICD-11: BA85]		[18]
ICD Disease Classification 12		Respiratory system disease	Click to Show/Hide
Benzonatate	API Info	Asthma [ICD-11: CA23]		[19]
ICD Disease Classification 13		Digestive system disease	Click to Show/Hide
Simethicone	API Info	Irritable bowel syndrome [ICD-11: DD91]		[20]
Rabeprazole	API Info	Gastro-oesophageal reflux disease [ICD-11: DA22]		[21]
Ursodeoxycholic acid	API Info	Hepatic fibrosis/cirrhosis [ICD-11: DB93]		[22]
Lubiprostone	API Info	Irritable bowel syndrome [ICD-11: DD91]		[23]
Rolapitant	API Info	Functional nausea/vomiting [ICD-11: DD90]		[24]
ICD Disease Classification 14		Skin disease	Click to Show/Hide
Isotretinoin	API Info	Acne vulgaris [ICD-11: ED80]		[25]
Tretinoin	API Info	Acne vulgaris [ICD-11: ED80]		[26]
ICD Disease Classification 15		Musculoskeletal/connective-tissue disease	Click to Show/Hide
Cyclosporin A	API Info	Rheumatoid arthritis [ICD-11: FA20]		[27]
ICD Disease Classification 16		Genitourinary system disease	Click to Show/Hide
Ibuprofen	API Info	Dysmenorrhea [ICD-11: GA34]		[28]
Tolterodine	API Info	Overactive bladder [ICD-11: GC50]		[29]
Dutasteride	API Info	Prostatic hyperplasia [ICD-11: GA90]		[30]
ICD Disease Classification 20		Developmental anomaly	Click to Show/Hide
Calcitriol	API Info	Congenital alopecia [ICD-11: LC30]		[31]

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
Cell line (CELL)
DBT Name: Colon cancer Caco-2 cells (Caco-2)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Inhibition ratio > 36 % (tested by experiment)		[32]
Tested Species	Homo sapiens (Human)

References
1	2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.
2	FDA label for approved cetirizine from the official website of the U.S. Food and Drug Administration.
3	FDA label for approved paricalcitol from the official website of the U.S. Food and Drug Administration.
4	FDA label for approved ergocalciferol from the official website of the U.S. Food and Drug Administration.
5	FDA label for approved doxercalciferol from the official website of the U.S. Food and Drug Administration.
6	FDA label for approved calcifediol from the official website of the U.S. Food and Drug Administration.
7	FDA label for approved venlafaxine from the official website of the U.S. Food and Drug Administration.
8	FDA label for approved methylphenidate from the official website of the U.S. Food and Drug Administration.
9	FDA label for approved guanfacine from the official website of the U.S. Food and Drug Administration.
10	FDA label for approved dextroamphetamine from the official website of the U.S. Food and Drug Administration.
11	FDA label for approved acetaminophen from the official website of the U.S. Food and Drug Administration.
12	FDA label for approved levetiracetam from the official website of the U.S. Food and Drug Administration.
13	FDA label for approved carbamazepine from the official website of the U.S. Food and Drug Administration.
14	FDA label for approved topiramate from the official website of the U.S. Food and Drug Administration.
15	FDA label for approved dextromethorphan from the official website of the U.S. Food and Drug Administration.
16	FDA label for approved acetazolamide from the official website of the U.S. Food and Drug Administration.
17	FDA label for approved diphenhydramine from the official website of the U.S. Food and Drug Administration.
18	FDA label for approved nimodipine from the official website of the U.S. Food and Drug Administration.
19	FDA label for approved benzonatate from the official website of the U.S. Food and Drug Administration.
20	FDA label for approved simethicone from the official website of the U.S. Food and Drug Administration.
21	FDA label for approved rabeprazole from the official website of the U.S. Food and Drug Administration.
22	FDA label for approved ursodeoxycholic acid from the official website of the U.S. Food and Drug Administration.
23	FDA label for approved lubiprostone from the official website of the U.S. Food and Drug Administration.
24	FDA label for approved rolapitant from the official website of the U.S. Food and Drug Administration.
25	FDA label for approved isotretinoin from the official website of the U.S. Food and Drug Administration.
26	FDA label for approved tretinoin from the official website of the U.S. Food and Drug Administration.
27	FDA label for approved cyclosporin A from the official website of the U.S. Food and Drug Administration.
28	FDA label for approved ibuprofen from the official website of the U.S. Food and Drug Administration.
29	FDA label for approved tolterodine from the official website of the U.S. Food and Drug Administration.
30	FDA label for approved dutasteride from the official website of the U.S. Food and Drug Administration.
31	FDA label for approved calcitriol from the official website of the U.S. Food and Drug Administration.
32	Interactions between human multidrug resistance related protein (MRP2; ABCC2) and excipients commonly used in self-emulsifying drug delivery systems (SEDDS). Int J Pharm. 2013 Apr 15;447(1-2):192-8.

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