Details of the Drug Formulation (DFM)
General Information of DFM (ID: F23765) | |||||
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Name |
Halcinonide 0.1% cream
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Company |
Sun Pharmaceutical Industries
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Active Pharmaceutical Ingredient (API) | Halcinonide | API Info click to show the detail info of this API | |||
Approved | |||||
Drug Inactive Ingredient (DIGs) | |||||
DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
E07AGB | DIG Info | Cetyl alcohol | Coating agent ... | ||
E0RB4Y | DIG Info | Dimethicone 350 | Antifoaming agent ... | ||
E0H2RX | DIG Info | Glyceryl monostearate | Emollient ... | ||
E0C3HB | DIG Info | Isopropyl palmitate | Emollient ... | ||
E0CP7I | DIG Info | Polysorbate 60 | Dispersing agent ... | ||
E0M1JK | DIG Info | Propylene glycol | Antimicrobial preservative ... | ||
E05BSD | DIG Info | Titanium dioxide | Coating agent ... | ||
E0H2SC | DIG Info | Water | Solvent | ||
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
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Oxidoreductase (ORase) | ||||||
DBT Name: Albendazole monooxygenase (CYP3A4) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Propylene glycol | |||||
Biological Activity | Inhibition ratio < 20 % (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Hydrolase (HDase) | ||||||
DBT Name: Acylsphingosine deacylase NAAA (ASAHL) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Isopropyl palmitate | |||||
Biological Activity | IC50 = 19000 nM (estimated based on the structural similarity with CHEMBL139056 ) | [2] | ||||
Structural Similarity | Tanimoto coefficient = 0.954545455 | |||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | NAAA_HUMAN | |||||
Primary active transporter (PAT) | ||||||
DBT Name: Multidrug resistance protein 2 (ABCC2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Glyceryl monostearate | |||||
Biological Activity | Inhibition ratio = 76 % (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | MRP2_HUMAN | |||||
DBT Name: Multidrug resistance protein 1 (ABCB1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Glyceryl monostearate | |||||
Biological Activity | Protein expression downregulation = 52.3 % (tested by experiment) | [4] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Glyceryl monostearate | |||||
Biological Activity | Inhibition ratio = 46 % (tested by experiment) | [4] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN | |||||
Experiment (3) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Glyceryl monostearate | |||||
Biological Activity | Inhibition ratio = 47 % (tested by experiment) | [4] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN | |||||
Cell line (CELL) | ||||||
DBT Name: Breast cancer FM3A cells (FM3A) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Cetyl alcohol | |||||
Biological Activity | EC50 = 1600 nM (estimated based on the structural similarity with CHEMBL28459 ) | [5] | ||||
Structural Similarity | Tanimoto coefficient = 0.861111111 | |||||
Tested Species | Mus musculus (Mouse) | |||||
Cellosaurus ID | CVCL_3869 | |||||
DBT Name: Prostate cancer LNCaP cells (LNCaP) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Glyceryl monostearate | |||||
Biological Activity | IC50 > 100000 nM (tested by experiment) | [6] | ||||
Tested Species | Homo sapiens (Human) | |||||
Cellosaurus ID | CVCL_0395 | |||||
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