Details of the Drug Formulation (DFM)
| General Information of DFM (ID: F23823) | |||||
|---|---|---|---|---|---|
| Name |
Mitomycin 5mg/vial injectable
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| Company |
Supergen
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| Active Pharmaceutical Ingredient (API) | Mitomycin |
API Info
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| Approved | |||||
| Drug Inactive Ingredient (DIGs) | |||||
| DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
| E09IKE | DIG Info | Hydroxyethyl-beta-cyclodextrin | Other agent | ||
| Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
|---|---|---|---|---|---|---|
| Potential-driven transporter (PDT) | ||||||
| DBT Name: Solute carrier SLCO1B1 (OATP-C) | Click to Show/Hide | |||||
| Detailed Information |
DBT Info
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| Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Hydroxyethyl-beta-cyclodextrin | |||||
| Biological Activity | IC50 = 0.24 %(w/v) (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | SO1B1_HUMAN | |||||
| DBT Name: Solute carrier SLCO2B1 (OATPB) | Click to Show/Hide | |||||
| Detailed Information |
DBT Info
click to show the detail info of this DBT
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| Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Hydroxyethyl-beta-cyclodextrin | |||||
| Biological Activity | IC50 = 0.01 %(w/v) (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | SO2B1_HUMAN | |||||
| DBT Name: Solute carrier SLCO1A2 (OATP-A) | Click to Show/Hide | |||||
| Detailed Information |
DBT Info
click to show the detail info of this DBT
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| Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Hydroxyethyl-beta-cyclodextrin | |||||
| Biological Activity | IC50 = 0.027 %(w/v) (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | SO1A2_HUMAN | |||||
| Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Hydroxyethyl-beta-cyclodextrin | |||||
| Biological Activity | IC50 = 0.025 %(w/v) (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | SO1A2_HUMAN | |||||
| DBT Name: Organic anion transporter 8 (OAT8) | Click to Show/Hide | |||||
| Detailed Information |
DBT Info
click to show the detail info of this DBT
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| Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Hydroxyethyl-beta-cyclodextrin | |||||
| Biological Activity | IC50 = 0.001 %(w/v) (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | SO1B3_HUMAN | |||||
| DBT Name: Sodium/bile acid cotransporter (SLC10A1) | Click to Show/Hide | |||||
| Detailed Information |
DBT Info
click to show the detail info of this DBT
|
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| Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Hydroxyethyl-beta-cyclodextrin | |||||
| Biological Activity | EC50 = 0.52 %(w/v) (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | NTCP_HUMAN | |||||
| Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Hydroxyethyl-beta-cyclodextrin | |||||
| Biological Activity | IC50 = 4.6 %(w/v) (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | NTCP_HUMAN | |||||
| References | |||||
|---|---|---|---|---|---|
| 1 | Pharmaceutical excipients influence the function of human uptake transporting proteins. Mol Pharm. 2012 Sep 4;9(9):2577-81. | ||||
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