General Information of DFM (ID: F23877)
Name	Remdesivir 100mg/20ml solution
Company	Gilead Sciences
Active Pharmaceutical Ingredient (API)	Remdesivir		API Info click to show the detail info of this API
				Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0WT2I	DIG Info	Betadex sulfobutyl ether sodium	Solubilizing agent
	E0H0KW	DIG Info	Hydrochloric acid	Acidulant
	E0L2PN	DIG Info	Sodium hydroxide	Alkalizing agent
	E0H2SC	DIG Info	Water	Solvent

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Lyase/isomerase/ligase (L/I/G)
DBT Name: Carbonic anhydrase IV (CA4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Hydrochloric acid
Biological Activity	Ki = 90000 nM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CAH4_HUMAN
DBT Name: Carbonic anhydrase V (CA5)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Hydrochloric acid
Biological Activity	Ki = 156 nM (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	CAH5A_HUMAN ; CAH5B_HUMAN

References
1	Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions. Bioorg Med Chem Lett. 2004 Dec 6; 14(23):5769-73.
2	Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1; 14(21):5435-9.

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