General Information of DFM (ID: F24216)
Name	Methylnaltrexone Bromide 8mg/0.4ml solution
Company	Salix Pharms
Active Pharmaceutical Ingredient (API)	Methylnaltrexone bromide		API Info click to show the detail info of this API
				Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0KF3M	DIG Info	Edetate calcium disodium	Complexing agent
	E0L7RZ	DIG Info	Glycine hydrochloride	Buffering agent ...
	E0T4TW	DIG Info	Sodium chloride	Diluent ...

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Transmembrane channel/porin (TC/P)
DBT Name: Glutamate receptor NMDA (GRIN)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Glycine hydrochloride
Biological Activity	EC50 = 68 nM (estimated based on the structural similarity with CHEMBL773 )					[1]
Structural Similarity	Tanimoto coefficient = 0.964285714
Tested Species	Rattus norvegicus (Rat)
UniProt ID	NMDZ1_RAT ; NMDE1_RAT ; NMDE2_RAT ; NMDE3_RAT ; NMDE4_RAT ; NMD3A_RAT ; NMD3B_RAT
DBT Name: Glycine receptor alpha-1 (GLRA1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Glycine hydrochloride
Biological Activity	EC50 = 94000 nM (estimated based on the structural similarity with CHEMBL773 )					[2]
Structural Similarity	Tanimoto coefficient = 0.964285714
Tested Species	Homo sapiens (Human)
UniProt ID	GLRA1_HUMAN

References
1	Design, synthesis and structure-activity relationships of novel strychnine-insensitive glycine receptor ligands. Bioorg Med Chem Lett. 1999 May 17; 9(10):1409-14.
2	Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal alpha7 nicotinic acetylcholine receptor. J Med Chem. 2007 Sep 20; 50(19):4616-29.

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