Details of the Drug Formulation (DFM)
| General Information of DFM (ID: F24241) | |||||
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| Name |
Clopidogrel Bisulfate 75mg tablet
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| Company |
Denton Pharma Dba Northwind Pharmaceuticals; Graviti Pharmaceuticals Private Limited
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| Active Pharmaceutical Ingredient (API) | Clopidogrel |
API Info
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| Deep vein thrombosis | ICD-11: BD71 | Approved | |||
| Drug Inactive Ingredient (DIGs) | |||||
| DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
| E0V2QO | DIG Info | Cellulose microcrystalline | Adsorbent ... | ||
| E0P9YZ | DIG Info | Hydrophobic colloidal silica | Anticaking agent ... | ||
| E0J4OX | DIG Info | Hydroxypropyl cellulose | Binding agent ... | ||
| E00DHW | DIG Info | Lactose monohydrate | Binding agent ... | ||
| E0LI5P | DIG Info | Trihydroxystearin | Emollient ... | ||
| Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
|---|---|---|---|---|---|---|
| Oxidoreductase (ORase) | ||||||
| DBT Name: Mephenytoin 4-hydroxylase (CYP2C19) | Click to Show/Hide | |||||
| Detailed Information |
DBT Info
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| Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Hydroxypropyl cellulose | |||||
| Biological Activity | EC50 = 89.5 uM (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CP2CJ_HUMAN | |||||
| DBT Name: Debrisoquine 4-hydroxylase (CYP2D6) | Click to Show/Hide | |||||
| Detailed Information |
DBT Info
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| Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Hydroxypropyl cellulose | |||||
| Biological Activity | EC50 = 148.3 uM (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CP2D6_HUMAN | |||||
| Lyase/isomerase/ligase (L/I/G) | ||||||
| DBT Name: Cholesterol 25-hydroxylase (CYP1A2) | Click to Show/Hide | |||||
| Detailed Information |
DBT Info
click to show the detail info of this DBT
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| Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Hydroxypropyl cellulose | |||||
| Biological Activity | EC50 = 139 uM (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CP1A2_HUMAN | |||||
| References | |||||
|---|---|---|---|---|---|
| 1 | Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48. | ||||
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