Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0P9YZ)
DIG Name	Hydrophobic colloidal silica
Synonyms	Click to Show/Hide the Synonyms of This DIG Silica; SILICON DIOXIDE; Quartz; 7631-86-9; Cristobalite; Dioxosilane; Diatomaceous earth; Tridymite; Silica gel; Sand; Infusorial earth; Silicic anhydride; Aerosil; KIESELGUHR; Crystalline silica; 112945-52-5; Diatomaceous silica; Dicalite; Wessalon; Glass; Ludox; Nyacol; 14808-60-7; Zorbax sil; Silica, amorphous; Cab-O-sil; Christensenite; Crystoballite; Silicon(IV) oxide; Siliceous earth; Amorphous silica; QUARTZ (SIO2); 61790-53-2; Silica, colloidal; 112926-00-8; Chalcedony; Diatomite; Agate; Cab-o-sil M-5; colloidal silica; Cristobalite (SiO2); Fused silica; Quartz glass; Quartz sand; Silica slurry; Silicone dioxide; 60676-86-0; SILICA, VITREOUS; Colloidal silicon dioxide; Siliceous earth, purified; Min-U-Sil; Silicon dioxide (amorphous); Silicon dioxide, fumed; Siliziumdioxid; 14464-46-1; UNII-ETJ7Z6XBU4; 91053-39-3; Kieselsaeureanhydrid; 15468-32-3; CHEBI:30563; SiO2; (SiO2)n; 43-63C; MFCD00011232; ETJ7Z6XBU4; Silicon dioxide, colloidal; ENT 25,550; [SiO2]; Silica, crystalline - fused; Silicagel; Silicon dioxide, amorphous gel; Silicondioxide; Silica gel desiccant, indicating; Celite; Sand, Ottawa; Sand, Sea; silica gel desiccant; MFCD00217788; Silica, mesostructured; Sillikolloid; Acticel; Aerosil 380; Amethyst; Aquafil; Carplex; Cataloid; Crysvarl; Extrusil; Flintshot; Nalcoag; Novaculite; Porasil; Santocel; Silikil; Silikill; Siloxid; Sipernat; Superfloss; Vulkasil; Cherts; Neosil; Neosyl; Snowit; Aerosil-degussa; Imsil; Metacristobalite; Silica vitreous; Zipax; Quartz silica; alpha-Quartz; Fossil flour; Quartz dust; Rock crystal; Rose quartz; Silica dust; White carbon; Chromosorb P; Silica particles; Tiger-eye; Vulkasil S; Celite superfloss; Cristobalite dust; Snowtex O; Corasil II; Silver bond B; Cab-O-sperse; alpha-Cristobalite; alpha-Crystobalite; Calcined diatomite; Tokusil TPLM; Dri-Die; Gold bond R; Cabosil st-1; Manosil vn 3; Sil-Co-Sil; Ultrasil VH 3; Ultrasil VN 3; Aerosil bs-50; Aerosil K 7; Cabosil N 5; Carplex 30; Carplex 80; Pigment White 27; Siderite (SiO2); Snowtex 30; Syton 2X; Tridymite 118; Zeofree 80; Cab-O-grip II; Silicon(IV) oxide, amorphous; Tridimite [French]; Amorphous silica gel; HI-Sil; Tridymite (SiO2); Glass wool, for laboratory use; Positive sol 232; Sand, pure, 40-100 mesh; Aerogel 200; Aerosil 300; Amorphous silica dust; Ludox hs 40; Silanox 101; Silica (SiO2); Vitasil 220; Positive sol 130M; Siliceous earth, purified (NF); Siliceous earth, purified [NF]; Silicon Oxide Hollow Nanospheres; Aerosil A 300; Aerosil E 300; Aerosil M-300; Nyacol 830; Sibelite M 3000; Sibelite M 4000; Sibelite M 6000; Quazo puro [Italian]; Caswell No. 734A; Nalfloc N 1050; Quso 51; Sicron F 300; Sikron F 100; Spectrosil; Accusand; Coesite; Fuselex; Nalcast; Nyacol 1430; Optocil; Quartzine; Quarzsand; Rancosil; Suprasil; Tridimite; Silica, amorphous fused; Siltex; Vitreous quartz; Vitreous silica; Tridymite dust; W 12 (Filler); beta-Quartz; Fumed silica; Fused quartz; MIN-U-sil alpha quartz; Quartz-beta; Quso G 30; Silica glass; Amorphous quartz; Dri-Die insecticide 67; Nalco 1050; Quazo puro; Silica, amorphous, fumed; Vitrified silica; MFCD00163736; Pyrogenic colloidal silica; Sand, for analysis, 40-100 mesh; Silica gel, spherical, 60 angstroms; Synthetic amorphous silica; Hydrophobic silica 2482; Silica, fused; Suprasil W; Vitreosil IR; Borsil P; Calcined diatomaceous earth; Silica gel, spherical, 100 angstroms; Silica gel, spherical, 300 angstroms; Silane, dioxo-; Crystallized silicon dioxide; Optocil (quartz); CP-SilicaPLOT; Diatomaceous earth, calcined; Silicon oxide, di- (sand); Quarzsand [German]; S-Col; Admafine SO 25H; Admafine SO 25R; Admafine SO 32H; Admafine SO-C 2; Admafine SO-C 3; Cristobalite asbestos; Keatite (SiO2); Sg-67; Silica, amorphous, fumed, cryst.-free; Fumed silica, crystalline-free; Stishovite (SiO2); ED-C (silica); Fuselex ZA 30; As 1 (silica); CCRIS 2475; CCRIS 3699; DQ12; Agate (SiO2); Celite 545; Dimethyl siloxanes and silicones; Fumed synthetic amorphous silica; Silica, crystalline - tridymite; FB 5 (silica); Fuselex RD 120; Corning 7940; Microcrystalline quartz; Synthetic amorphous silica, fumed; Denka F 90; Denka FB 30; Denka FB 44; Denka FB 74; Denka FS 30; Dri-Die 67; Silica gel spherical, 40-75 mum particle size; WGL 300; Cryptocrystalline quartz; FB 20 (silica); Elsil 100; F 44 (filler); D & D; SF 35; Elsil BF 100; F 125 (silica); F 160 (silica); Silicon dioxide, 99.998%, (trace metal basis); Fuselex RD 40-60; Silica, amorphous, fused; Silicon dioxide, chemically prepared; EINECS 231-545-4; EINECS 238-455-4; EINECS 238-878-4; EINECS 239-487-1; HK 400; TGL 16319; Celite(R), for analysis, high purity analytical grade; Silica gel 60, 0.060-0.2mm (70-230 mesh); Silica, crystalline quartz; Silicon dioxide (vitreous); EPA Pesticide Chemical Code 072605; Silica 2482, hydrophobic; CI 7811; Silica, crystalline, quartz; Silica, crystalline: quartz; GP 7I; Silica gel, for chromatography, 0.030-0.200 mm, 60 A; Silica gel, for chromatography, 0.035-0.070 mm, 90 A; Silica gel, for chromatography, 0.075-0.250 mm, 150 A; Silica gel, for drying purposes, non-toxic grade, 3-6 mm; CAB-O-SIL N-70TS; Silica, crystalline tridymite; Kieselgel; Silica, crystalline - quartz; AF-SO 25R; Quartz [Silica, crystalline]; Silica gel, for column chrom., ultrapure, 60-200 $6, 60A; Zorbax; quartz-glass; Silicom dioxide; Silica flour (powdered crystalline silica); Silica, crystalline: tridymite; silica-gel; Fused-silica; Silica,fumed; silicium dioxide; AI3-25549; GP 11I; RD 8; silica-; Silica, fumed; U 333; W 006; Silicon di-oxide; Tridymite [Silica, crystalline]; CRS 1102RD8; Silica Dispersion; SiO2 Nanopowder; Silica gel G; Silica, crystalline: cristobalite; Silica, tridymite; SiO2 Nanospheres; Diatomaceous earth, flux-calcined, filter aid, treated with sodium carbonate, flux calcined; Silica gel 60 ADAMANT(TM) on TLC plates, with fluorescent indicator 254 nm; EF 10; FS 74; MR 84; Silica, crystalline - cristobalite; Silica Microspheres; Cristobalite [Silica, crystalline]; Silica gel, functionalized, (cyclohexylcarbodiimido)propyl, ca. 0,9 mmol-g, particle size: 40-63 micron; Amorphous silica: Pyrogenic (fumed); EINECS 262-373-8; Silica gel, ASTM; Silica Nanoparticles; Methyl3-oxohexanoate; Siliceous sand, CP; BF 100; EQ 912; QG 100; RD 120; Celite 503; Nettles p.e. extract; Silicon Dioxide Powder; Silica, fumed, powder; Silicon dioxide (NF); Activated Silica Powder; Activated Silicon Oxide; Sand 50-70 mesh; F 44; Silica gel, large pore; Y 40; SiO2.xH2O; Hollow Silica Nanosphere; Silicon Oxide Dispersion; Silicon Oxide Nanopowder; Activated Silicon Dioxide; Crystalline Silica Quartz; Silica gel, ACS reagent; Cab-O-sil(R) M-5; Celite(R) 512 medium; Kieselguhr, -325 mesh; Silica, 99.8%; SBA-15 Molecular Sieve; Silicon dioxide Nanopowder; Diatomaceous earth, powder; DSSTox_CID_9677; Silicon Dioxide Dispersion; Epitope ID:158537; Silica, fumed, hydrophobic; Silicon Dioxide Nanospheres; Silicon Oxide Nanoparticles; EC 231-545-4; Celite(R) 503, CP; Celite(R) 535, CP; Celite(R) 545, CP; Nano Silicon Dioxide Powder; DSSTox_RID_78805; DSSTox_GSID_29677; Silicon dioxide, acid washed; Silicon(IV) oxide (SiO2); 13778-37-5; 13778-38-6; 15723-40-7; 17679-64-0; 99439-28-8; Silica fibers, 1/4'' long; Kieselguhr, calcined, purified; Silica gel, CP, blue, beads; Silica Nanoparticles Dispersion; Silica, fused, respirable dust; 25wt% Silicon Oxide in Water; AW Standard Super-Cel(R) NF; MCM-41; Silica gel, CP, mixed, beads; Silica gel, CP, white, beads; Silicates (<1% crystalline silica):Graphite, natural; Hyflo(R) Super-Cel(R), CP; CHEMBL3188292; DTXSID1029677; Filter agent, Celite(R) 545; Sand, white quartz, CP, beads; Quarz cryst., 0.6-1.3 mm; Silicon dioxide, colloidal (NF); Diatomaceous earth, flux-calcined; Silicon dioxide, SAJ first grade; Diatomaceous earth non-washed, CP; Silica Gel Dessicant (Grade 03); Silica gel, CP, blue, bead size; Filter agent, Celatom(R) FW-14; Filter agent, Celatom(R) FW-50; Filter agent, Celatom(R) FW-60; Filter agent, Celatom(R) FW-80; Silica, fused [Silica, amorphous]; Silicon dioxide, JIS special grade; Silicon Oxide Mesoporous Nanopowder; AMY37125; Chromosorb(R) G, 80-100 mesh; 2-Mercaptoethyl ethyl sulfide silica; Celite(R) 545 AW, reagent grade; Silica gel 60, 230-400 mesh; Silica Hollow Nanospheres Dispersion; Silicon(IV) oxide, electronic grade; Tox21_301288; MFCD07370733; Sand, white quartz, CP, crystalline; Silica gel, indicating, 6-16 mesh; Chromosorb(R) W/AW, 45-60 mesh; Light anhydrous silicic acid (JP17); Quarz fine, cryst., 0.4-0.8 mm; Silica gel, 70-200 mesh (TLC); Silica, fumed, powder, 0.008 mum; AKOS009085429; Silica Gel, 40-63 Micron Particles; Silicon Dioxide Nanospheres Properties; DB11132; Iron Sulfide (FeS) Sputtering Targets; Silicon Dioxide Nanoparticle Dispersion; Glass spheres, 9-13 mum particle size; Quartz (silicon dioxide), silver, pure; Silica gel, CP, white, medium granules; Silica gel, technical grade, 3-9 mesh; Silica, mesostructured, HMS (wormhole); NCGC00257531-01; Sand, white quartz, purum p.a., powder; Silica gel orange, granular, 0.2-1 mm; Silicon Oxide Nanoparticles / Nanopowder; Silicon(IV) oxide, powder, 0.5 micron; Silicon(IV) oxide, powder, 1.0 micron; Silicon(IV) oxide, powder, 1.5 micron; 14639-89-5; 92283-58-4; E551; Silica gel, CP, blue, bead size, medium; Silica gel, technical grade, 6-16 mesh; Silicon oxide powder, 99% Nano, 20 nm; CAS-7631-86-9; Silica gel desiccant, -3+8 mesh granules; Silica gel, 12-24 mesh (liquid drying); Silica gel, CP, mixed, bead size, medium; Silica gel, for column chromatography, 60; Silicon Dioxide Nanoparticles / Nanopowder; Celite(R) 281, filter aid, flux calcined; Celite(R) S, filter aid, dried, untreated; Chromosorb(R) W/AW-DMCS, 80-100 mesh; Quarz min. 99% powdered, up to 125 ?m; Silica gel desiccant, -6+12 mesh granules; Silicon dioxide, purum p.a., acid purified; White Silica Gel Beads, 3 mm (2-5 mm); FT-0624621; FT-0645127; FT-0689145; FT-0689270; FT-0696592; FT-0696603; FT-0697331; FT-0697389; FT-0700917; Quartz rod, fused, 2.0mm (0.079in) dia; Quartz rod, fused, 5.0mm (0.197in) dia; S0821; S0822; Silica gel, with 1-4 mm moisture indicator; Silica, amorphous, fumed (crystalline free); Silicon dioxide Nanopowder KH550 processing; Silicon dioxide Nanopowder KH570 processing; Celite(R) 110, filter aid, flux calcinated; Celite(R) 512 medium, filter aid, calcined; Chromosorb(R) G/AW-DMCS, 100-120 mesh; Chromosorb(R) W/AW-DMCS, 120-140 mesh; K-411 Glass microspheres, NIST SRM 2066; Quar
DIG Function	Anticaking agent; Emulsion stabilizing agent; Glidant; Suspending agent; Viscosity-controlling agent
PubChem CID	24261
Formula	O2Si
Canonical SMILES	O=[Si]=O
InChI	1S/O2Si/c1-3-2
InChIKey	VYPSYNLAJGMNEJ-UHFFFAOYSA-N
	Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=24261"></iframe>
Structure	3D MOL		2D MOL
Physicochemical Properties	Molecular Weight	60.084	Topological Polar Surface Area	34.1
	XlogP	N.A.	Complexity	18.3
	Heavy Atom Count	3	Rotatable Bond Count	0
	Hydrogen Bond Donor Count	0	Hydrogen Bond Acceptor Count	2

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 01		Infectious/parasitic disease	Click to Show/Hide
Crofelemer	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[1]
Simeprevir	API Info	Viral hepatitis [ICD-11: 1E51]		[2]
Bedaquiline	API Info	Pulmonary tuberculosis [ICD-11: 1B10]		[3]
ICD Disease Classification 02		Benign/in-situ/malignant neoplasm	Click to Show/Hide
Trametinib	API Info	Melanoma [ICD-11: 2C30]		[4]
Enasidenib	API Info	Acute myeloid leukemia [ICD-11: 2A60]		[5]
Cabozantinib	API Info	Thyroid cancer [ICD-11: 2D10]		[6]
Neratinib	API Info	Breast cancer [ICD-11: 2C60]		[7]
Rucaparib	API Info	Ovarian cancer [ICD-11: 2C73]		[8]
Dabrafenib	API Info	Melanoma [ICD-11: 2C30]		[9]
Nilotinib	API Info	Chronic myelogenous leukaemia [ICD-11: 2A20]		[10]
Ponatinib	API Info	Acute lymphoblastic leukemia [ICD-11: 2B33]		[11]
ICD Disease Classification 03		Blood/blood-forming organ disease	Click to Show/Hide
Ruxolitinib	API Info	Thrombocytosis [ICD-11: 3B63]		[12]
ICD Disease Classification 05		Endocrine/nutritional/metabolic disease	Click to Show/Hide
Atorvastatin	API Info	Hyperlipidaemia [ICD-11: 5C8Z]		[13]
Pravastatin	API Info	Dyslipidaemia [ICD-11: 5C81]		[14]
Cysteamine	API Info	Nephropathic cystinosis [ICD-11: 5C60]		[15]
Lorcaserin	API Info	Obesity [ICD-11: 5B81]		[16]
Pitavastatin	API Info	Hyperlipidaemia [ICD-11: 5C8Z]		[17]
ICD Disease Classification 06		Mental/behavioural/neurodevelopmental disorder	Click to Show/Hide
Venlafaxine	API Info	Major depressive disorder [ICD-11: 6A70]		[18]
Buspirone	API Info	Anxiety disorder [ICD-11: 6B00]		[19]
Molindone	API Info	Schizophrenia [ICD-11: 6A20]		[20]
Naltrexone	API Info	Alcohol dependence [ICD-11: 6C40]		[21]
Nefazodone	API Info	Major depressive disorder [ICD-11: 6A70]		[22]
ICD Disease Classification 08		Nervous system disease	Click to Show/Hide
Gabapentin	API Info	Focal seizure [ICD-11: 8A68]		[23]
Tizanidine	API Info	Tic disorder [ICD-11: 8A05]		[24]
Tiagabine	API Info	Epilepsy [ICD-11: 8A60]		[25]
Sumatriptan	API Info	Migraine [ICD-11: 8A80]		[26]
Valbenazine	API Info	Dyskinesia [ICD-11: 8A02]		[27]
Safinamide	API Info	Parkinsonism [ICD-11: 8A00]		[28]
ICD Disease Classification 09		Visual system disease	Click to Show/Hide
Dextromethorphan	API Info	Allergic conjunctivitis [ICD-11: 9A60]		[29]
ICD Disease Classification 11		Circulatory system disease	Click to Show/Hide
Amlodipine	API Info	Angina pectoris [ICD-11: BA40]		[30]
Clopidogrel	API Info	Deep vein thrombosis [ICD-11: BD71]		[31]
Sotalol	API Info	Atrial fibrillation [ICD-11: BC81]		[32]
Benazepril	API Info	Essential hypertension [ICD-11: BA00]		[33]
Midodrine	API Info	Orthostatic hypotension [ICD-11: BA21]		[34]
Betaxolol	API Info	Essential hypertension [ICD-11: BA00]		[35]
Bisoprolol	API Info	Essential hypertension [ICD-11: BA00]		[36]
Amiloride	API Info	Essential hypertension [ICD-11: BA00]		[37]
Aliskiren	API Info	Essential hypertension [ICD-11: BA00]		[38]
Dronedarone	API Info	Atrial fibrillation [ICD-11: BC81]		[39]
Ivabradine	API Info	Angina pectoris [ICD-11: BA40]		[40]
ICD Disease Classification 12		Respiratory system disease	Click to Show/Hide
Fexofenadine	API Info	Allergic rhinitis [ICD-11: CA08]		[41]
ICD Disease Classification 13		Digestive system disease	Click to Show/Hide
Ondansetron	API Info	Gastritis [ICD-11: DA42]		[42]
Rolapitant	API Info	Functional nausea/vomiting [ICD-11: DD90]		[43]
ICD Disease Classification 14		Skin disease	Click to Show/Hide
Terbinafine	API Info	Onychomycosis [ICD-11: EE12]		[44]
ICD Disease Classification 15		Musculoskeletal/connective-tissue disease	Click to Show/Hide
Raloxifene	API Info	Osteoporosis [ICD-11: FB83]		[45]
ICD Disease Classification 16		Genitourinary system disease	Click to Show/Hide
Terazosin	API Info	Prostatic hyperplasia [ICD-11: GA90]		[46]

References
1	FDA label for approved crofelemer from the official website of the U.S. Food and Drug Administration.
2	FDA label for approved simeprevir from the official website of the U.S. Food and Drug Administration.
3	FDA label for approved bedaquiline from the official website of the U.S. Food and Drug Administration.
4	FDA label for approved trametinib from the official website of the U.S. Food and Drug Administration.
5	FDA label for approved enasidenib from the official website of the U.S. Food and Drug Administration.
6	FDA label for approved cabozantinib from the official website of the U.S. Food and Drug Administration.
7	FDA label for approved neratinib from the official website of the U.S. Food and Drug Administration.
8	FDA label for approved rucaparib from the official website of the U.S. Food and Drug Administration.
9	FDA label for approved dabrafenib from the official website of the U.S. Food and Drug Administration.
10	FDA label for approved nilotinib from the official website of the U.S. Food and Drug Administration.
11	FDA label for approved ponatinib from the official website of the U.S. Food and Drug Administration.
12	FDA label for approved ruxolitinib from the official website of the U.S. Food and Drug Administration.
13	FDA label for approved atorvastatin from the official website of the U.S. Food and Drug Administration.
14	FDA label for approved pravastatin from the official website of the U.S. Food and Drug Administration.
15	FDA label for approved cysteamine from the official website of the U.S. Food and Drug Administration.
16	FDA label for approved lorcaserin from the official website of the U.S. Food and Drug Administration.
17	FDA label for approved pitavastatin from the official website of the U.S. Food and Drug Administration.
18	FDA label for approved venlafaxine from the official website of the U.S. Food and Drug Administration.
19	FDA label for approved buspirone from the official website of the U.S. Food and Drug Administration.
20	FDA label for approved molindone from the official website of the U.S. Food and Drug Administration.
21	FDA label for approved naltrexone from the official website of the U.S. Food and Drug Administration.
22	FDA label for approved nefazodone from the official website of the U.S. Food and Drug Administration.
23	FDA label for approved gabapentin from the official website of the U.S. Food and Drug Administration.
24	FDA label for approved tizanidine from the official website of the U.S. Food and Drug Administration.
25	FDA label for approved tiagabine from the official website of the U.S. Food and Drug Administration.
26	FDA label for approved sumatriptan from the official website of the U.S. Food and Drug Administration.
27	FDA label for approved valbenazine from the official website of the U.S. Food and Drug Administration.
28	FDA label for approved safinamide from the official website of the U.S. Food and Drug Administration.
29	FDA label for approved dextromethorphan from the official website of the U.S. Food and Drug Administration.
30	FDA label for approved amlodipine from the official website of the U.S. Food and Drug Administration.
31	FDA label for approved clopidogrel from the official website of the U.S. Food and Drug Administration.
32	FDA label for approved sotalol from the official website of the U.S. Food and Drug Administration.
33	FDA label for approved benazepril from the official website of the U.S. Food and Drug Administration.
34	FDA label for approved midodrine from the official website of the U.S. Food and Drug Administration.
35	FDA label for approved betaxolol from the official website of the U.S. Food and Drug Administration.
36	FDA label for approved bisoprolol from the official website of the U.S. Food and Drug Administration.
37	FDA label for approved amiloride from the official website of the U.S. Food and Drug Administration.
38	FDA label for approved aliskiren from the official website of the U.S. Food and Drug Administration.
39	FDA label for approved dronedarone from the official website of the U.S. Food and Drug Administration.
40	FDA label for approved ivabradine from the official website of the U.S. Food and Drug Administration.
41	FDA label for approved fexofenadine from the official website of the U.S. Food and Drug Administration.
42	FDA label for approved ondansetron from the official website of the U.S. Food and Drug Administration.
43	FDA label for approved rolapitant from the official website of the U.S. Food and Drug Administration.
44	FDA label for approved terbinafine from the official website of the U.S. Food and Drug Administration.
45	FDA label for approved raloxifene from the official website of the U.S. Food and Drug Administration.
46	FDA label for approved terazosin from the official website of the U.S. Food and Drug Administration.

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