Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00578)
Name
Rabeprazole
Synonyms    Click to Show/Hide the Synonyms of This API
rabeprazole; 117976-89-3; Aciphex; Habeprazole; Pariets; LY307640; CHEBI:8768; Sodium rabeprazole; 2-[[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl]-1H-benzimidazole; 2-(((4-(3-Methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole; 2-({[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfinyl)-1H-benzimidazole; Rabeprazole [INN:BAN]; 1H-Benzimidazole, 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-; rabeprazol; Rabeloc; 1H-Benzimidazole, 2-(((4-(3-methoxypropoxy)-3-methyl-2-pyridinyl)methyl)sulfinyl)-; Rabeprazole (INN); Eraloc (TN); HSDB 7321; LY 307640; 2-[{4-(3-methoxypropoxy)-3-methylpyridin-2-yl}methylsulfinyl]-1H-benzimidazole; 2-{[4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl}-1H-benzimidazole; 2-(((4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole; 2--1H-benzimidazole; 2-((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methylsulfinyl)-1H-benzo[d]imidazole; CHEMBL1219; SCHEMBL23336; MLS001401446; BIDD:GT0019; GTPL7290; DTXSID3044122; HMS2052P03; HMS3394P03; BCP06638; HY-B0656; ANW-57672; BDBM50070209; E-3810 (PPI); MFCD00868879; STL186112; AKOS015895259; CCG-101158; DB01129; MCULE-7848941080; NC00408; PB21725; 2-{[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methanesulfinyl}-1H-1,3-benzodiazole; NCGC00388029-07; NCGC00388029-09; AK-55871; AS-34993; SMR000469174; SBI-0206867.P001; AB0107093; DB-020298; DS-002860; FT-0602569; FT-0674301; FT-0674302; C07864; D08463; Q-1236; AB00698237-06; 976R893; A803856; SR-01000763041; J-003691; SR-01000763041-3; BRD-A39390670-236-04-0; (R)-2-(((4-(3-Methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole; (S)-2-(((4-(3-Methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole; 1H-benzimidazole,2-[(r)-[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-; 2-({[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methane}sulfinyl)-1H-1,3-benzodiazole; 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]-methyl] sulfinyl]-1H-benzimidazole; 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]-methyl]sulfinyl]-1H-benzimidazole; 2-[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methylsulfinyl]-1H-benzimidazole; 2-[[4-(3-methoxypropoxy)-3-methyl-pyridin-2-yl]methylsulfinyl]-1H-benzimidazole; 2-{[(3-Methyl-4-(3-methoxypropoxy)-2-pyridinyl)methyl]sulphinyl}1H-benzimidazole; 2-{4-(3-Methoxypropoxy)-3-methylpyridine-2-yl}methylsulfinyl-1H-benzimidazole
Clinical Status
Approved
Disease Indication Gastro-oesophageal reflux disease ICD-11: DA22 [1]
PubChem CID
5029
Formula
C18H21N3O3S
Canonical SMILES
CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCCCOC
InChI
1S/C18H21N3O3S/c1-13-16(19-9-8-17(13)24-11-5-10-23-2)12-25(22)18-20-14-6-3-4-7-15(14)21-18/h3-4,6-9H,5,10-12H2,1-2H3,(H,20,21)
InChIKey
YREYEVIYCVEVJK-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5029"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 359.4 Topological Polar Surface Area 96.3
XlogP 1.9 Complexity 440
Heavy Atom Count 25 Rotatable Bond Count 8
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 6
Full List of Drug Formulations (DFMs) Containing This API
          Rabeprazole 20 mg tablet Click to Show/Hide the Full List of Formulation(s):        20 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Oleic acid; Sodium lauryl sulfate; Fd&c blue no. 2; Fd&c yellow no. 6; Magnesium stearate; Mannitol; Ammonia; Ferrosoferric oxide; Magnesium oxide; Propylene glycol; Sodium hydroxide; Talc; Titanium dioxide; Triacetin; Triethyl citrate; Croscarmellose sodium; Medium-chain triglycerides; Polysorbate 80; Silicon dioxide; Ethylcellulose, unspecified; Hydroxypropyl cellulose (1200000 mw); Hypromellose, unspecified; Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Polydextrose; Polyethylene glycol, unspecified
                   Dosage Form Delayed Release Oral Tablet
                   Company Proficient Rx
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Oleic acid DIG Info Liver lipid-binding protein (Ki = 180 nM) [2]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [6]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [7]
Medium-chain triglyceride DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 36 %) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Oleic acid; Sodium lauryl sulfate; Fd&c blue no. 2; Fd&c yellow no. 6; Magnesium stearate; Mannitol; Ammonia; Ferrosoferric oxide; Magnesium oxide; Propylene glycol; Sodium hydroxide; Talc; Titanium dioxide; Triacetin; Triethyl citrate; Croscarmellose sodium; Medium-chain triglycerides; Polysorbate 80; Silicon dioxide; Ethylcelluloses; Hydroxypropyl cellulose (type h); Hypromelloses; Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Polydextrose; Polyethylene glycols
                   Dosage Form Delayed Release Oral Tablet
                   Company Golden State Medical Supply; Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Oleic acid DIG Info Liver lipid-binding protein (Ki = 180 nM) [2]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [6]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [7]
Medium-chain triglyceride DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 36 %) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; D&c yellow no. 10; Fd&c yellow no. 6; Magnesium stearate; Mannitol; Ferrosoferric oxide; Magnesium oxide; Propylene glycol; Titanium dioxide; Triethyl citrate; Polyethylene glycol 4000; Aluminum oxide; Hydroxypropyl cellulose (1200000 mw); Hypromellose 2910 (15 mpa.s); Hypromellose phthalate (31% phthalate, 40 cst); Hypromellose, unspecified; Low-substituted hydroxypropyl cellulose, unspecified; Microcrystalline cellulose; Shellac
                   Dosage Form Delayed Release Oral Tablet
                   Company Preferred Pharamaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [4]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Polyethylene glycol 4000 DIG Info Albendazole monooxygenase (Inhibition ratio < 40 %) [6]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; D&c yellow no. 10; Fd&c yellow no. 6; Magnesium stearate; Mannitol; Ferrosoferric oxide; Magnesium oxide; Propylene glycol; Titanium dioxide; Triethyl citrate; Polyethylene glycol 4000; Aluminum oxide; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hydroxypropyl cellulose, low substituted; Hypromellose 2910 (15 mpa.s); Hypromellose phthalate (31% phthalate, 40 cst); Hypromelloses; Shellac
                   Dosage Form Delayed Release Oral Tablet
                   Company AvKARE
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [4]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Polyethylene glycol 4000 DIG Info Albendazole monooxygenase (Inhibition ratio < 40 %) [6]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; D&c yellow no. 10; Fd&c yellow no. 6; Magnesium stearate; Mannitol; Ferrosoferric oxide; Magnesium oxide; Propylene glycol; Titanium dioxide; Triethyl citrate; Polyethylene glycol 4000; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hydroxypropyl cellulose, low substituted; Hypromellose 2910 (15 mpa.s); Hypromellose phthalate (31% phthalate, 40 cst); Hypromelloses; Shellac
                   Dosage Form Delayed Release Oral Tablet
                   Company Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [4]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Polyethylene glycol 4000 DIG Info Albendazole monooxygenase (Inhibition ratio < 40 %) [6]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium stearyl fumarate; Diethyl phthalate; Magnesium stearate; Mannitol; Ammonia; Ferric oxide yellow; Ferrosoferric oxide; Magnesium oxide; Propylene glycol; Talc; Titanium dioxide; Crospovidone (12 mpa.s at 5%); Ethylcellulose, unspecified; Hypromellose phthalate (24% phthalate, 55 cst); Low-substituted hydroxypropyl cellulose, unspecified; Shellac
                   Dosage Form Delayed Release Oral Tablet
                   Company Preferred Pharamaceuticals; Unit Dose Services
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [9]
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [4]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium stearyl fumarate; Diethyl phthalate; Magnesium stearate; Mannitol; Ammonia; Ferric oxide yellow; Ferrosoferric oxide; Magnesium oxide; Propylene glycol; Talc; Titanium dioxide; Crospovidone (12 mpa.s at 5%); Ethylcelluloses; Hydroxypropyl cellulose, low substituted; Hypromellose phthalate (24% phthalate, 55 cst); Shellac
                   Dosage Form Delayed Release Oral Tablet
                   Company Amneal Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [9]
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [4]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium stearyl fumarate; Magnesium stearate; Mannitol; Ferric oxide red; Ferric oxide yellow; Propylene glycol; Sodium hydroxide; Talc; Titanium dioxide; Crospovidone; Carnauba wax; Diacetylated monoglycerides; Ethylcelluloses; Hydroxypropyl cellulose (type h); Hypromellose phthalate (24% phthalate, 55 cst)
                   Dosage Form Delayed Release Oral Tablet
                   Company Carilion Materials Management; Eisai
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [9]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium stearyl fumarate; Magnesium stearate; Mannitol; Ferric oxide red; Ferric oxide yellow; Propylene glycol; Sodium hydroxide; Talc; Titanium dioxide; Crospovidone; Carnauba wax; Ethylcelluloses; Hydroxypropyl cellulose (type h); Hypromellose phthalate (24% phthalate, 55 cst)
                   Dosage Form Delayed Release Oral Tablet
                   Company Cardinal Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [9]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium stearyl fumarate; Magnesium stearate; Mannitol; Ferric oxide red; Ferric oxide yellow; Propylene glycol; Sodium hydroxide; Talc; Titanium dioxide; Crospovidone; Carnauba wax; Ethylcelluloses; Hydroxypropyl cellulose; Hypromellose phthalate (24% phthalate, 55 cst)
                   Dosage Form Delayed Release Oral Tablet
                   Company Bryant Ranch Prepack; Lake Eire Medical & Surgical Supply DBA Quality Care Products
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [9]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium stearyl fumarate; Magnesium stearate; Mannitol; Ferric oxide yellow; Ferrosoferric oxide; Magnesium oxide; Talc; Titanium dioxide; Lecithin, soybean; Polyvinyl alcohol; Carnauba wax; Crospovidone (15 mpa.s at 5%); Diacetylated monoglycerides; Ethylcelluloses; Hydroxypropyl cellulose (type h); Hypromellose phthalate (24% phthalate, 55 cst); Polyethylene glycols; Shellac
                   Dosage Form Delayed Release Oral Tablet
                   Company Preferred Pharamaceuticals; Proficient Rx
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [9]
Polyvinyl alcohol DIG Info Debrisoquine 4-hydroxylase (EC50 = 354.8 uM) [10]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Soybean lecithin DIG Info Albendazole monooxygenase (IC50 = 6.61 mg.mL-1) [6]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium stearyl fumarate; Magnesium stearate; Mannitol; Ferric oxide yellow; Ferrosoferric oxide; Magnesium oxide; Talc; Titanium dioxide; Crospovidone; Lecithin, soybean; Carnauba wax; Diacetylated monoglycerides; Ethylcelluloses; Hydroxypropyl cellulose (type h); Hypromellose phthalate (24% phthalate, 55 cst); Polyethylene glycols; Polyvinyl alcohol, unspecified; Shellac
                   Dosage Form Delayed Release Oral Tablet
                   Company Lupin Pharmaceuticals; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Soybean lecithin DIG Info Albendazole monooxygenase (IC50 = 6.61 mg.mL-1) [6]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium stearyl fumarate; Magnesium stearate; Mannitol; Ferric oxide yellow; Ferrosoferric oxide; Magnesium oxide; Talc; Titanium dioxide; Lecithin, soybean; Carnauba wax; Crospovidone (15 mpa.s at 5%); Diacetylated monoglycerides; Ethylcellulose, unspecified; Hydroxypropyl cellulose (1200000 mw); Hypromellose phthalate (24% phthalate, 55 cst); Polyethylene glycol, unspecified; Polyvinyl alcohol, unspecified; Shellac
                   Dosage Form Delayed Release Oral Tablet
                   Company A-S Medication Solutions
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Soybean lecithin DIG Info Albendazole monooxygenase (IC50 = 6.61 mg.mL-1) [6]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium stearyl fumarate; Magnesium stearate; Mannitol; Ferric oxide yellow; Sodium hydroxide; Talc; Titanium dioxide; Crospovidone; Carnauba wax; Ethylcelluloses; Hydroxypropyl cellulose
                   Dosage Form Delayed Release Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 15 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Diethyl phthalate; Magnesium stearate; Mannitol; Ferric oxide yellow; Magnesium oxide; Talc; Titanium dioxide; Povidone; Ethylcelluloses; Hypromellose phthalate (31% phthalate, 40 cst); Sodium starch glycolate type a potato
                   Dosage Form Delayed Release Oral Tablet
                   Company NuCare Pharmaceuticals; RemedyRepack; Torrent Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [4]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [10]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 16 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Diethyl phthalate; Magnesium stearate; Mannitol; Ferric oxide yellow; Magnesium oxide; Talc; Titanium dioxide; Povidone; Ethylcelluloses; Hypromellose phthalate (31% phthalate, 40 cst); Sodium starch glycolate type a potato
                   Dosage Form Delayed Release Oral Tablet
                   Company DirectRX
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [4]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [10]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 17 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Mannitol; Ammonia; Ferric oxide yellow; Ferrosoferric oxide; Magnesium oxide; Propylene glycol; Talc; Titanium dioxide; Diacetylated monoglycerides; Ethylcellulose, unspecified; Hydroxypropyl cellulose (1200000 mw); Hypromellose phthalate (31% phthalate, 40 cst); Low-substituted hydroxypropyl cellulose, unspecified; Shellac
                   Dosage Form Delayed Release Oral Tablet
                   Company Breckenridge Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 18 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Diethyl phthalate; Magnesium stearate; Mannitol; Ferric oxide yellow; Magnesium oxide; Talc; Titanium dioxide; Ethylcelluloses; Hypromellose phthalate (31% phthalate, 40 cst); Povidones; Sodium starch glycolate type a potato
                   Dosage Form Delayed Release Oral Tablet
                   Company Preferred Pharamaceuticals; Proficient Rx
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 19 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Diethyl phthalate; Magnesium stearate; Mannitol; Ferric oxide yellow; Magnesium oxide; Talc; Titanium dioxide; Ethylcelluloses; Hypromellose phthalate (31% phthalate, 40 cst); Sodium starch glycolate type a potato
                   Dosage Form Delayed Release Oral Tablet
                   Company Major Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 20 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Mannitol; Ferric oxide yellow; Ferrosoferric oxide; Magnesium hydroxide; Magnesium oxide; Sodium carbonate; Talc; Titanium dioxide; Crospovidone (15 mpa.s at 5%); Diacetylated monoglycerides; Ethylcellulose (7 mpa.s); Hydroxypropyl cellulose (200000 mw); Hypromellose phthalate (31% phthalate, 40 cst); Low-substituted hydroxypropyl cellulose, unspecified; Shellac
                   Dosage Form Delayed Release Oral Tablet
                   Company Aurobindo Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
          Rabeprazole 10 mg granules Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c yellow no. 6; Magnesium stearate; Mannitol; Potassium chloride; Magnesium oxide; Talc; Titanium dioxide; Silicon dioxide; Carrageenan; Diacetylated monoglycerides; Ethylcelluloses; Hydroxypropyl cellulose (type h); Hypromellose phthalate (24% phthalate, 55 cst)
                   Dosage Form Oral Granules
                   Company Avadel Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Potassium chloride DIG Info Carbonic anhydrase IV (Ki = 90000 nM) [11]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
          Rabeprazole 5 mg granules Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c blue no. 2; Magnesium stearate; Mannitol; Potassium chloride; Magnesium oxide; Talc; Titanium dioxide; Silicon dioxide; Aluminum oxide; Carrageenan; Diacetylated monoglycerides; Ethylcelluloses; Hydroxypropyl cellulose (type h); Hypromellose phthalate (24% phthalate, 55 cst)
                   Dosage Form Oral Granules
                   Company Avadel Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Potassium chloride DIG Info Carbonic anhydrase IV (Ki = 90000 nM) [11]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
References
1 FDA label for approved rabeprazole from the official website of the U.S. Food and Drug Administration.
2 Characterization of the drug binding specificity of rat liver fatty acid binding protein. J Med Chem. 2008 Jul 10; 51(13):3755-64.
3 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
4 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
5 Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective. Bioorg Med Chem Lett. 2017 Jun 1; 27(11):2239-2258.
6 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
7 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
8 Interactions between human multidrug resistance related protein (MRP2; ABCC2) and excipients commonly used in self-emulsifying drug delivery systems (SEDDS). Int J Pharm. 2013 Apr 15;447(1-2):192-8.
9 Synthesis and evaluation of (-)-Massoialactone and analogues as potential anticancer and anti-inflammatory agents. Eur J Med Chem. 2014 Apr 9; 76:291-300.
10 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
11 Characterization and anions inhibition studies of an -carbonic anhydrase from the teleost fish Dicentrarchus labrax. Bioorg Med Chem. 2011 Jan 15; 19(2):744-8.

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