Details of the Drug Inactive Ingredient (DIG)
Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG | ||||||
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ICD Disease Classification 05 | Endocrine/nutritional/metabolic disease | Click to Show/Hide | ||||
Chlorpropamide
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API Info |
Diabetes mellitus [ICD-11: 5A10]
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[1] | |||
ICD Disease Classification 06 | Mental/behavioural/neurodevelopmental disorder | Click to Show/Hide | ||||
Risperidone
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API Info |
Schizophrenia [ICD-11: 6A20]
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[2] | |||
Fluoxetine
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API Info |
Major depressive disorder [ICD-11: 6A70]
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[3] | |||
Duloxetine
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API Info |
Major depressive disorder [ICD-11: 6A70]
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[4] | |||
ICD Disease Classification 08 | Nervous system disease | Click to Show/Hide | ||||
Rizatriptan
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API Info |
Migraine [ICD-11: 8A80]
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[5] | |||
ICD Disease Classification 15 | Musculoskeletal/connective-tissue disease | Click to Show/Hide | ||||
Cyclosporin A
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API Info |
Rheumatoid arthritis [ICD-11: FA20]
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[6] | |||
ICD Disease Classification 16 | Genitourinary system disease | Click to Show/Hide | ||||
Dutasteride
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API Info |
Prostatic hyperplasia [ICD-11: GA90]
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[7] | |||
Full List of Biological Targets of DIG (DBTs) Regulated by This DIG | ||||||
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Lyase/isomerase/ligase (L/I/G) | ||||||
DBT Name: Serine racemase (SRR) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | Ki = 366000 nM (tested by experiment) | [8] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | SRR_HUMAN | |||||
Potential-driven transporter (PDT) | ||||||
DBT Name: Glycine type-1 transporter (GlyT-1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | IC50 = 31600 nM (tested by experiment) | [9] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | SC6A9_HUMAN | |||||
Transmembrane channel/porin (TC/P) | ||||||
DBT Name: Glutamate receptor NMDA (GRIN) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | Ki = 125.89 nM (tested by experiment) | [10] | ||||
Tested Species | Rattus norvegicus (Rat) | |||||
UniProt ID | NMDZ1_RAT ; NMDE1_RAT ; NMDE2_RAT ; NMDE3_RAT ; NMDE4_RAT ; NMD3A_RAT ; NMD3B_RAT | |||||
DBT Name: Glycine receptor alpha-1 (GLRA1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | EC50 = 94000 nM (tested by experiment) | [11] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | GLRA1_HUMAN | |||||
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