Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E09ZKW)
DIG Name
Fumaric acid
Synonyms    Click to Show/Hide the Synonyms of This DIG
fumaric acid; 110-17-8; 2-Butenedioic acid; trans-Butenedioic acid; Allomaleic acid; Boletic acid; fumarate; (2E)-but-2-enedioic acid; Lichenic acid; Tumaric acid; trans-2-Butenedioic acid; trans-1,2-Ethylenedicarboxylic acid; Allomalenic acid; (E)-2-Butenedioic acid; But-2-enedioic acid; 2-Butenedioic acid (2E)-; 2-Butenedioic acid (E)-; Kyselina fumarova; USAF EK-P-583; Butenedioic acid; Butenedioic acid, (E)-; (2E)-2-butenedioic acid; 2-Butenedioic acid, (E)-; Caswell No. 465E; FEMA No. 2488; FEMA Number 2488; 2-(E)-Butenedioic acid; (E)-but-2-enedioic acid; NSC-2752; 1,2-Ethylenedicarboxylic acid, (E); CCRIS 1039; HSDB 710; U-1149; trans-but-2-enedioic acid; 1,2-Ethenedicarboxylic acid, trans-; EPA Pesticide Chemical Code 051201; Fumaric acid (NF); Fumaric acid [NF]; UNII-88XHZ13131; AI3-24236; MFCD00002700; CHEBI:18012; NSC2752; FC 33; 88XHZ13131; 6915-18-0; fum; E297; Fumaric acid, 99+%; Lichenic acid (VAN); DSSTox_CID_1518; Futrans-2-Butenedioic Acid; (E)-2-Butenedioate; (E)-Butenedioic acid; DSSTox_RID_76195; DSSTox_GSID_21518; Kyselina fumarova [Czech]; (2E)-but-2-enedioate; Malezid CM; H2male; Fumarsaeure; Fumaricum acidum; CAS-110-17-8; fumarate, 10; cis-but-2-enedioic acid; E-2-Butenedioic acid; Fumaric acid (8CI); EINECS 203-743-0; FC 33 (acid); Scotchbond Multipurpose Etchant; (2Z)-but-2-enedioate; BRN 0605763; Allomaleate; Boletate; Lichenate; fumeric acid; Cis-butenedioate; 2-Butenedioate; Modified Gumrosin; (z)-butenedioate; trans-Butenedioate; fumaric acid group; NCGC00091192-02; cis-2-Butenedioate; Fumaric Acid,(S); Maleic Acid (MA); cis-but-2-enedioate; Fumaric acid solution; trans-2-Butenedioate; Fumaric Acid (FA); 2-(E)-Butenedioate; Fumaric acid, 99%; (2Z)-2-Butenedioate; (Trans)-butenedioic acid; (2Z)-Butene-2-dioate; F0067; Fumaric acid, >=99%; bmse000083; (2Z)-2-Butenedioic acid; EC 203-743-0; Maleic acid [NA2215]; WLN: QV1U1VQ-T; SCHEMBL1177; (2Z)-Butene-2-dioic acid; (E)-but-2-enedioate;hydron; 4-02-00-02202 (Beilstein Handbook Reference); MLS002454406; 2-butenedioic acid, (2E)-; (2E)-2-Butenedioic acid #; CHEMBL503160; INS NO.297; Fumaric Acid (Fragrance Grade); trans-1,2-Ethylenedicarboxylate; DTXSID3021518; BDBM26122; CHEBI:22958; INS-297; HMS2270C12; Pharmakon1600-01301022; Fumaric acid, >=99.0% (T); AMY30339; MAE; STR02646; ZINC3860193; Tox21_201769; Tox21_302826; 2-Butenedioic acid (2E)- (9CI); BBL022974; Fumaric acid, >=99%, FCC, FG; NSC760395; s4952; AKOS000118896; Fumaric acid, qNMR Standard for DMSO; CCG-266065; CS-W016599; DB01677; HY-W015883; NE10214; NSC-760395; NCGC00091192-01; NCGC00091192-03; NCGC00256360-01; NCGC00259318-01; AK113080; BP-13087; Fumaric acid, tested according to USP/NF; LS-12976; SMR000112117; Fumaric acid, puriss., >=99.5% (T); 746-EP2269610A2; 746-EP2269983A1; 746-EP2269984A1; 746-EP2269988A2; 746-EP2269989A1; 746-EP2269990A1; 746-EP2270002A1; 746-EP2270006A1; 746-EP2270008A1; 746-EP2270011A1; 746-EP2270505A1; 746-EP2272516A2; 746-EP2272822A1; 746-EP2272827A1; 746-EP2275401A1; 746-EP2275404A1; 746-EP2275411A2; 746-EP2275413A1; 746-EP2275424A1; 746-EP2277507A1; 746-EP2277848A1; 746-EP2277858A1; 746-EP2277866A1; 746-EP2277867A2; 746-EP2280003A2; 746-EP2280009A1; 746-EP2280010A2; 746-EP2281559A1; 746-EP2281563A1; 746-EP2284149A1; 746-EP2284160A1; 746-EP2284169A1; 746-EP2284170A1; 746-EP2284174A1; 746-EP2284178A2; 746-EP2284179A2; 746-EP2286795A1; 746-EP2287147A2; 746-EP2287153A1; 746-EP2287155A1; 746-EP2287156A1; 746-EP2287160A1; 746-EP2287161A1; 746-EP2287162A1; 746-EP2289510A1; 746-EP2289518A1; 746-EP2289879A1; 746-EP2289883A1; 746-EP2289890A1; 746-EP2292231A1; 746-EP2292234A1; 746-EP2292592A1; 746-EP2292611A1; 746-EP2292617A1; 746-EP2295401A2; 746-EP2295402A2; 746-EP2295406A1; 746-EP2295416A2; 746-EP2295423A1; 746-EP2295424A1; 746-EP2295426A1; 746-EP2295427A1; 746-EP2295433A2; 746-EP2295437A1; 746-EP2298731A1; 746-EP2298735A1; 746-EP2298746A1; 746-EP2298747A1; 746-EP2298748A2; 746-EP2298755A1; 746-EP2298757A2; 746-EP2298758A1; 746-EP2298759A1; 746-EP2298767A1; 746-EP2298768A1; 746-EP2298772A1; 746-EP2298775A1; 746-EP2298779A1; 746-EP2301544A1; 746-EP2301922A1; 746-EP2301923A1; 746-EP2301931A1; 746-EP2301937A1; 746-EP2301940A1; 746-EP2305219A1; 746-EP2305257A1; 746-EP2305633A1; 746-EP2305636A1; 746-EP2305641A1; 746-EP2305646A1; 746-EP2305651A1; 746-EP2305653A1; 746-EP2305655A2; 746-EP2305657A2; 746-EP2305660A1; 746-EP2305664A1; 746-EP2305669A1; 746-EP2305672A1; 746-EP2305673A1; 746-EP2305675A1; 746-EP2305679A1; 746-EP2305683A1; 746-EP2308839A1; 746-EP2308849A1; 746-EP2308850A1; 746-EP2308851A1; 746-EP2308854A1; 746-EP2308857A1; 746-EP2308869A1; 746-EP2308871A1; 746-EP2308875A1; 746-EP2308877A1; 746-EP2309584A1; 746-EP2311801A1; 746-EP2311802A1; 746-EP2311803A1; 746-EP2311804A2; 746-EP2311807A1; 746-EP2311809A1; 746-EP2311810A1; 746-EP2311811A1; 746-EP2311814A1; 746-EP2311821A1; 746-EP2311822A1; 746-EP2311824A1; 746-EP2311834A1; 746-EP2311839A1; 746-EP2311842A2; 746-EP2314295A1; 746-EP2314575A1; 746-EP2314585A1; 746-EP2314586A1; 746-EP2314587A1; 746-EP2314589A1; 746-EP2314593A1; 746-EP2316457A1; 746-EP2316458A1; 746-EP2316459A1; 746-EP2316825A1; 746-EP2316826A1; 746-EP2316827A1; 746-EP2316828A1; 746-EP2316831A1; 746-EP2316836A1; 746-EP2316837A1; 746-EP2371802A1; 746-EP2371814A1; 746-EP2374780A1; 746-EP2374781A1; 746-EP2380874A2; E-297; Fumaric acid, Vetec(TM) reagent grade, 99%; 1, (E); C00122; D02308; Q139857; Fumaric acid 1000 microg/mL in Acetonitrile:Water; Fumaric acid, BioReagent, suitable for cell culture; J-002389; F8886-8257; Fumaric acid, certified reference material, TraceCERT(R); 26B3632D-E93F-4655-90B0-3C17855294BA; Fumaric acid, anhydrous, free-flowing, Redi-Dri(TM), >=99%; Fumaric acid, European Pharmacopoeia (EP) Reference Standard; Fumaric acid, United States Pharmacopeia (USP) Reference Standard; Fumaric acid solution, TraceCERT(R), 1H-qNMR Standard, 1 mg/g in D2O; Fumaric Acid, Pharmaceutical Secondary Standard; Certified Reference Material; Fumaric acid, PharmaGrade, USP/NF, Manufactured under appropriate GMP controls for pharma or biopharmaceutical production.
DIG Function
Acidulant; Antioxidant; Complexing agent; Flavoring agent; Solubilizing agent
PubChem CID
444972
Formula
C4H4O4
Canonical SMILES
C(=C/C(=O)O)\\C(=O)O
InChI
1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+
InChIKey
VZCYOOQTPOCHFL-OWOJBTEDSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=444972"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 116.07 Topological Polar Surface Area 74.6
XlogP -0.3 Complexity 119
Heavy Atom Count 8 Rotatable Bond Count 2
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 4
Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
       ICD Disease Classification 01 Infectious/parasitic disease Click to Show/Hide
Quinine
 API Info
Malaria [ICD-11: 1F40]
 [1]
       ICD Disease Classification 04 Immune system disease Click to Show/Hide
Cetirizine
 API Info
Allergy [ICD-11: 4A80]
 [2]
       ICD Disease Classification 05 Endocrine/nutritional/metabolic disease Click to Show/Hide
Nateglinide
 API Info
Diabetes mellitus [ICD-11: 5A10]
 [3]
       ICD Disease Classification 06 Mental/behavioural/neurodevelopmental disorder Click to Show/Hide
Bupropion
 API Info
Nicotine dependence [ICD-11: 6C4A]
 [4]
Quetiapine
 API Info
Schizophrenia [ICD-11: 6A20]
 [5]
Guanfacine
 API Info
Attention deficit hyperactivity disorder [ICD-11: 6A05]
 [6]
       ICD Disease Classification 08 Nervous system disease Click to Show/Hide
Morphine
 API Info
Anaesthesia [ICD-11: 8E22]
 [7]
Donepezil
 API Info
Alzheimer disease [ICD-11: 8A20]
 [8]
       ICD Disease Classification 11 Circulatory system disease Click to Show/Hide
Diltiazem
 API Info
Essential hypertension [ICD-11: BA00]
 [9]
Verapamil
 API Info
Essential hypertension [ICD-11: BA00]
 [10]
Azilsartan medoxomil
 API Info
Essential hypertension [ICD-11: BA00]
 [11]
       ICD Disease Classification 15 Musculoskeletal/connective-tissue disease Click to Show/Hide
Naproxen
 API Info
Rheumatoid arthritis [ICD-11: FA20]
 [12]
       ICD Disease Classification 16 Genitourinary system disease Click to Show/Hide
Ibuprofen
 API Info
Dysmenorrhea [ICD-11: GA34]
 [13]
       ICD Disease Classification 17 Sexual health-related condition Click to Show/Hide
Avanafil
 API Info
Erectile dysfunction [ICD-11: HA01]
 [14]
Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
      Oxidoreductase (ORase)
            DBT Name: N1-methyl adenine demethylase (FTO) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 150000 nM (tested by experiment) [15]
                    Tested Species Homo sapiens (Human)
                    UniProt ID FTO_HUMAN
            DBT Name: HIF-prolyl hydroxylase 2 (EGLN1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 19000 nM (tested by experiment) [16]
                    Tested Species Homo sapiens (Human)
                    UniProt ID EGLN1_HUMAN
References
1 FDA label for approved quinine from the official website of the U.S. Food and Drug Administration.
2 FDA label for approved cetirizine from the official website of the U.S. Food and Drug Administration.
3 FDA label for approved nateglinide from the official website of the U.S. Food and Drug Administration.
4 FDA label for approved bupropion from the official website of the U.S. Food and Drug Administration.
5 FDA label for approved quetiapine from the official website of the U.S. Food and Drug Administration.
6 FDA label for approved guanfacine from the official website of the U.S. Food and Drug Administration.
7 FDA label for approved morphine from the official website of the U.S. Food and Drug Administration.
8 FDA label for approved donepezil from the official website of the U.S. Food and Drug Administration.
9 FDA label for approved diltiazem from the official website of the U.S. Food and Drug Administration.
10 FDA label for approved verapamil from the official website of the U.S. Food and Drug Administration.
11 FDA label for approved azilsartan medoxomil from the official website of the U.S. Food and Drug Administration.
12 FDA label for approved naproxen from the official website of the U.S. Food and Drug Administration.
13 FDA label for approved ibuprofen from the official website of the U.S. Food and Drug Administration.
14 FDA label for approved avanafil from the official website of the U.S. Food and Drug Administration.
15 Structural basis for inhibition of the fat mass and obesity associated protein (FTO). J Med Chem. 2013 May 9; 56(9):3680-8.
16 Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases. J Med Chem. 2008 Nov 27; 51(22):7053-6.

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