Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00308)
Name
Guanfacine
Synonyms    Click to Show/Hide the Synonyms of This API
GUANFACINE; 29110-47-2; Guanfacinum [INN-Latin]; Guanfacina [INN-Spanish]; N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide; UNII-30OMY4G3MK; 30OMY4G3MK; Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-; N-amidino-2-(2,6-dichlorophenyl)acetamide; CHEBI:5558; N-carbamimidoyl-2-(2,6-dichlorophenyl)acetamide; SPD 503; Guanfacina; Guanfacinum; Guanfacine [INN:BAN]; NCGC00015469-05; EINECS 249-442-8; Guanfacine (INN); Estulic (TN); Tenex (Salt/Mix); Estulic (Salt/Mix); Tocris-1030; Prestwick0_000339; Prestwick1_000339; Prestwick2_000339; Prestwick3_000339; Guanfacine-13C-15N3; Lopac-G-1043; CHEMBL862; LON 798 (Salt/Mix); Lopac0_000519; SCHEMBL35094; BSPBio_000377; GTPL522; RASPBERRYKETONEGLUCOSIDE; SPBio_002298; BPBio1_000415; DTXSID9046944; BDBM81984; BCP09647; NSC_3519; ZINC3872738; Guanfacine hydrochloride (Salt/Mix); HY-17416A; (2,6-dichlorophenylacetyl)-guanidine; [(2,6-dichlorophenyl)acetyl]guanidine; AKOS030255657; CCG-204609; DB01018; SDCCGSBI-0050502.P002; MRF-0000019; NCGC00015469-01; NCGC00015469-02; NCGC00015469-03; NCGC00015469-04; NCGC00015469-06; NCGC00015469-07; NCGC00024950-01; NCGC00024950-02; NCGC00024950-03; AB0109150; CAS-29110-48-3; CAS_29110-47-2; FT-0669067; FT-0669068; C07037; D08031; AB01563079_01; L000286; L013430; J-017394; Q5613599; BRD-K32830106-003-03-0; BRD-K32830106-003-11-3; N-(Diaminomethyliden)-2-(2,6-dichlorophenyl)acetamid
Clinical Status
Approved
Disease Indication Attention deficit hyperactivity disorder ICD-11: 6A05 [1]
PubChem CID
3519
Formula
C9H9Cl2N3O
Canonical SMILES
C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl
InChI
1S/C9H9Cl2N3O/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13/h1-3H,4H2,(H4,12,13,14,15)
InChIKey
INJOMKTZOLKMBF-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=3519"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 246.09 Topological Polar Surface Area 81.5
XlogP 2 Complexity 256
Heavy Atom Count 15 Rotatable Bond Count 2
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 1
Full List of Drug Formulations (DFMs) Containing This API
          Guanfacine 3 mg tablet Click to Show/Hide the Full List of Formulation(s):          9 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Oleic acid; Lactose monohydrate; D&c yellow no. 10; Fd&c blue no. 2; Glyceryl dibehenate; Magnesium stearate; Ammonia; Medium-chain triglycerides; Silicon dioxide; Cellulose, microcrystalline; Crospovidone (15 mpa.s at 5%); Ethylcelluloses; Hypromelloses; Polyethylene glycols; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Oleic acid DIG Info Liver lipid-binding protein (Ki = 180 nM) [2]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Medium-chain triglyceride DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 36 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Fumaric acid; Crospovidone; Povidone; Silicon dioxide; Cellulose, microcrystalline; Glyceryl behenate/eicosadioate; Hydroxypropyl cellulose (700000 mw); Hypromelloses
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Actavis Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Fumaric acid DIG Info HIF-prolyl hydroxylase 2 (IC50 = 19000 nM) [7]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [8]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Fd&c blue no. 1; Magnesium stearate; Silicon dioxide; Hypromellose, unspecified; Microcrystalline cellulose; Polyvinyl acetate phthalate; Povidone k12
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Golden State Medical Supply
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [6]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Fd&c blue no. 1; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polyvinyl acetate phthalate; Povidone k12
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Par Pharmaceutical; TWi Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [6]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Fumaric acid; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Glyceryl behenate/eicosadioate; Hydroxypropyl cellulose (type g); Hypromelloses; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company AvKARE
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Fumaric acid DIG Info HIF-prolyl hydroxylase 2 (IC50 = 19000 nM) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fumaric acid; Fd&c blue no. 2; Glyceryl dibehenate; Ferric oxide yellow; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Sun Pharmaceutical Industries
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Fumaric acid DIG Info HIF-prolyl hydroxylase 2 (IC50 = 19000 nM) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fumaric acid; Glyceryl dibehenate; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hypromellose 2208 (100 mpa.s); Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Sandoz
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Fumaric acid DIG Info HIF-prolyl hydroxylase 2 (IC50 = 19000 nM) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fumaric acid; Glyceryl dibehenate; Silicon dioxide; Crospovidone (15 mpa.s at 5%); Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Microcrystalline cellulose; Povidone, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Fumaric acid DIG Info HIF-prolyl hydroxylase 2 (IC50 = 19000 nM) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fumaric acid; Glyceryl dibehenate; Crospovidone (15 mpa.s at 5%); Hypromellose 2208 (15000 mpa.s); Methacrylic acid - methyl methacrylate copolymer (1:1); Microcrystalline cellulose; Povidone, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Shire
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Fumaric acid DIG Info HIF-prolyl hydroxylase 2 (IC50 = 19000 nM) [7]
          Guanfacine 4 mg tablet Click to Show/Hide the Full List of Formulation(s):          9 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Oleic acid; Lactose monohydrate; D&c yellow no. 10; Fd&c blue no. 2; Glyceryl dibehenate; Magnesium stearate; Ammonia; Medium-chain triglycerides; Silicon dioxide; Cellulose, microcrystalline; Crospovidone (15 mpa.s at 5%); Ethylcelluloses; Hypromelloses; Polyethylene glycols; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Oleic acid DIG Info Liver lipid-binding protein (Ki = 180 nM) [2]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Medium-chain triglyceride DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 36 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Fumaric acid; Crospovidone; Povidone; Silicon dioxide; Cellulose, microcrystalline; Glyceryl behenate/eicosadioate; Hydroxypropyl cellulose (700000 mw); Hypromelloses
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Actavis Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Fumaric acid DIG Info HIF-prolyl hydroxylase 2 (IC50 = 19000 nM) [7]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [8]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Fd&c blue no. 1; Magnesium stearate; Silicon dioxide; Hypromellose, unspecified; Microcrystalline cellulose; Polyvinyl acetate phthalate; Povidone k12
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Golden State Medical Supply
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [6]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Fd&c blue no. 1; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polyvinyl acetate phthalate; Povidone k12
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Par Pharmaceutical; TWi Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [6]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Fumaric acid; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Glyceryl behenate/eicosadioate; Hydroxypropyl cellulose (type g); Hypromelloses; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company AvKARE
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Fumaric acid DIG Info HIF-prolyl hydroxylase 2 (IC50 = 19000 nM) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fumaric acid; Fd&c blue no. 2; Glyceryl dibehenate; Ferric oxide yellow; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Sun Pharmaceutical Industries
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Fumaric acid DIG Info HIF-prolyl hydroxylase 2 (IC50 = 19000 nM) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fumaric acid; Glyceryl dibehenate; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hypromellose 2208 (100 mpa.s); Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Sandoz
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Fumaric acid DIG Info HIF-prolyl hydroxylase 2 (IC50 = 19000 nM) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fumaric acid; Glyceryl dibehenate; Silicon dioxide; Crospovidone (15 mpa.s at 5%); Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Microcrystalline cellulose; Povidone, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Fumaric acid DIG Info HIF-prolyl hydroxylase 2 (IC50 = 19000 nM) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fumaric acid; Glyceryl dibehenate; Crospovidone (15 mpa.s at 5%); Hypromellose 2208 (15000 mpa.s); Methacrylic acid - methyl methacrylate copolymer (1:1); Microcrystalline cellulose; Povidone, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Shire
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Fumaric acid DIG Info HIF-prolyl hydroxylase 2 (IC50 = 19000 nM) [7]
          Guanfacine 2 mg tablet Click to Show/Hide the Full List of Formulation(s):        17 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Oleic acid; Lactose monohydrate; D&c yellow no. 10; Glyceryl dibehenate; Magnesium stearate; Ammonia; Medium-chain triglycerides; Silicon dioxide; Cellulose, microcrystalline; Crospovidone (15 mpa.s at 5%); Ethylcelluloses; Hypromelloses; Polyethylene glycols; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Oleic acid DIG Info Liver lipid-binding protein (Ki = 180 nM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Medium-chain triglyceride DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 36 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fumaric acid; Fd&c yellow no. 6; Crospovidone; Povidone; Silicon dioxide; Cellulose, microcrystalline; Glyceryl behenate/eicosadioate; Hydroxypropyl cellulose (700000 mw); Hypromelloses
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Actavis Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [6]
Fumaric acid DIG Info HIF-prolyl hydroxylase 2 (IC50 = 19000 nM) [7]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [8]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous lactose; D&c yellow no. 10; Fd&c red no. 40; Povidone; Aluminum oxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Actavis Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [8]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium lauryl sulfate; Fd&c blue no. 1; Magnesium stearate; Silicon dioxide; Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company Golden State Medical Supply; Mylan Pharamceuticals; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [6]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fumaric acid; Fd&c yellow no. 6; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Glyceryl behenate/eicosadioate; Hydroxypropyl cellulose (type g); Hypromelloses; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company AvKARE
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [6]
Fumaric acid DIG Info HIF-prolyl hydroxylase 2 (IC50 = 19000 nM) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fumaric acid; Glyceryl dibehenate; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hypromellose 2208 (100 mpa.s); Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Sandoz
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Fumaric acid DIG Info HIF-prolyl hydroxylase 2 (IC50 = 19000 nM) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous lactose; D&c yellow no. 10; Povidone; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Promius Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [8]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Silicon dioxide; Hypromellose, unspecified; Microcrystalline cellulose; Polyvinyl acetate phthalate; Povidone k12
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Golden State Medical Supply
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polyvinyl acetate phthalate; Povidone k12
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Avera McKennan Hospital; Par Pharmaceutical; TWi Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium lauryl sulfate; Fd&c blue no. 1; Magnesium stearate; Cellulose, microcrystalline; Colloidal silicon dioxide
                   Dosage Form Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [6]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fumaric acid; Fd&c yellow no. 6; Silicon dioxide; Crospovidone, unspecified; Glyceryl behenate/eicosadioate; Hydroxypropyl cellulose (700000 mw); Hypromellose, unspecified; Microcrystalline cellulose; Povidone, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Bryant Ranch Prepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [6]
Fumaric acid DIG Info HIF-prolyl hydroxylase 2 (IC50 = 19000 nM) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; Magnesium stearate; Talc; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Epic Pharma; Golden State Medical Supply; PuraCap Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fumaric acid; Glyceryl dibehenate; Crospovidone; Cellulose, microcrystalline; Hypromellose 2208 (15000 mpa.s); Methacrylic acid - methyl methacrylate copolymer (1:1); Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company TYA Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Fumaric acid DIG Info HIF-prolyl hydroxylase 2 (IC50 = 19000 nM) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fumaric acid; Glyceryl dibehenate; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Sun Pharmaceutical Industries
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Fumaric acid DIG Info HIF-prolyl hydroxylase 2 (IC50 = 19000 nM) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 15 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fumaric acid; Glyceryl dibehenate; Silicon dioxide; Crospovidone (15 mpa.s at 5%); Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Microcrystalline cellulose; Povidone, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Fumaric acid DIG Info HIF-prolyl hydroxylase 2 (IC50 = 19000 nM) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 16 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fumaric acid; Glyceryl dibehenate; Crospovidone (15 mpa.s at 5%); Hypromellose 2208 (15000 mpa.s); Methacrylic acid - methyl methacrylate copolymer (1:1); Microcrystalline cellulose; Povidone, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Shire
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Fumaric acid DIG Info HIF-prolyl hydroxylase 2 (IC50 = 19000 nM) [7]
             Drug Formulation 17 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Amneal Pharmaceuticals; AvKARE; AvPAK; Major Pharmaceuticals; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
          Guanfacine 1 mg tablet Click to Show/Hide the Full List of Formulation(s):        19 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fumaric acid; Fd&c yellow no. 6; Crospovidone; Povidone; Silicon dioxide; Cellulose, microcrystalline; Glyceryl behenate/eicosadioate; Hydroxypropyl cellulose (700000 mw); Hypromelloses
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Actavis Pharma; Avera McKennan Hospital
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [6]
Fumaric acid DIG Info HIF-prolyl hydroxylase 2 (IC50 = 19000 nM) [7]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [8]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Oleic acid; Lactose monohydrate; Glyceryl dibehenate; Magnesium stearate; Ammonia; Medium-chain triglycerides; Silicon dioxide; Cellulose, microcrystalline; Crospovidone (15 mpa.s at 5%); Ethylcelluloses; Hypromelloses; Polyethylene glycols; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Oleic acid DIG Info Liver lipid-binding protein (Ki = 180 nM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Medium-chain triglyceride DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 36 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Fumaric acid; Glyceryl dibehenate; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hypromellose 2208 (100 mpa.s); Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Sandoz
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Fumaric acid DIG Info HIF-prolyl hydroxylase 2 (IC50 = 19000 nM) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fumaric acid; Fd&c yellow no. 6; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Glyceryl behenate/eicosadioate; Hydroxypropyl cellulose (type g); Hypromelloses; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company AvKARE
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [6]
Fumaric acid DIG Info HIF-prolyl hydroxylase 2 (IC50 = 19000 nM) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous lactose; Fd&c red no. 40; Povidone; Aluminum oxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Actavis Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [8]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous lactose; Fd&c red no. 40; Povidone; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Promius Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [8]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Silicon dioxide; Hypromellose, unspecified; Microcrystalline cellulose; Polyvinyl acetate phthalate; Povidone k12
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Golden State Medical Supply
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polyvinyl acetate phthalate; Povidone k12
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Par Pharmaceutical; TWi Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium lauryl sulfate; Magnesium stearate; Silicon dioxide; Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company Golden State Medical Supply; Mylan Pharamceuticals; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium lauryl sulfate; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Cardinal Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fumaric acid; Glyceryl dibehenate; Crospovidone; Cellulose, microcrystalline; Hypromellose 2208 (15000 mpa.s); Methacrylic acid - methyl methacrylate copolymer (1:1); Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company TYA Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Fumaric acid DIG Info HIF-prolyl hydroxylase 2 (IC50 = 19000 nM) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fumaric acid; Glyceryl dibehenate; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Sun Pharmaceutical Industries
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Fumaric acid DIG Info HIF-prolyl hydroxylase 2 (IC50 = 19000 nM) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fumaric acid; Glyceryl dibehenate; Silicon dioxide; Crospovidone (15 mpa.s at 5%); Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Microcrystalline cellulose; Povidone, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Fumaric acid DIG Info HIF-prolyl hydroxylase 2 (IC50 = 19000 nM) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous lactose; Fd&c red no. 40; Aluminum oxide; Cellulose, microcrystalline; Povidone k29/32
                   Dosage Form Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [6]
             Drug Formulation 15 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous lactose; Fd&c red no. 40; Aluminum oxide; Microcrystalline cellulose; Povidone, unspecified
                   Dosage Form Oral Tablet
                   Company Carilion Materials Management
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [6]
             Drug Formulation 16 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fumaric acid; Glyceryl dibehenate; Crospovidone (15 mpa.s at 5%); Hypromellose 2208 (15000 mpa.s); Methacrylic acid - methyl methacrylate copolymer (1:1); Microcrystalline cellulose; Povidone, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Shire
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Fumaric acid DIG Info HIF-prolyl hydroxylase 2 (IC50 = 19000 nM) [7]
             Drug Formulation 17 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company American Health Packaging; Amneal Pharmaceuticals; AvKARE; Major Pharmaceuticals; TYA Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
             Drug Formulation 18 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Atlantic Biologicals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
             Drug Formulation 19 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Talc; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Epic Pharma; Golden State Medical Supply; Proficient Rx; PuraCap Laboratories; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Guanfacine Hydrochloride eq 1mg base extended release tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Hypromellose; Methacrylic Acid Copolymer; Lactose; Povidone; Crospovidone; Microcrystalline Cellulose; Fumaric Acid; Glycerol Behenate; Green Pigment Blend Pb-1763
                   Dosage Form Extended Release Tablet
                   Company Takeda Pharms Usa
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Fumaric acid DIG Info HIF-prolyl hydroxylase 2 (IC50 = 19000 nM) [7]
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [8]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [8]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Guanfacine Hydrochloride eq 1mg base tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&C Red 40 Aluminum Lake; D&C Yellow 10 Aluminum Lake; Lactose; Microcrystalline Cellulose; Povidone; Stearic Acid
                   Dosage Form Tablet
                   Company Promius Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [8]
References
1 FDA label for approved guanfacine from the official website of the U.S. Food and Drug Administration.
2 Characterization of the drug binding specificity of rat liver fatty acid binding protein. J Med Chem. 2008 Jul 10; 51(13):3755-64.
3 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
4 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
5 Interactions between human multidrug resistance related protein (MRP2; ABCC2) and excipients commonly used in self-emulsifying drug delivery systems (SEDDS). Int J Pharm. 2013 Apr 15;447(1-2):192-8.
6 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
7 Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases. J Med Chem. 2008 Nov 27; 51(22):7053-6.
8 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.

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