Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0GY8T)
DIG Name	Sodium alginate
DIG Function	Binding agent; Disintegrant; Suspending agent; Viscosity-controlling agent

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 01		Infectious/parasitic disease	Click to Show/Hide
Quinine	API Info	Malaria [ICD-11: 1F40]		[1]
ICD Disease Classification 05		Endocrine/nutritional/metabolic disease	Click to Show/Hide
Glyburide	API Info	Diabetes mellitus [ICD-11: 5A10]		[2]
ICD Disease Classification 06		Mental/behavioural/neurodevelopmental disorder	Click to Show/Hide
Paroxetine	API Info	Major depressive disorder [ICD-11: 6A70]		[3]
Lithium carbonate	API Info	Bipolar disorder [ICD-11: 6A60]		[4]
Cyclobenzaprine	API Info	Major depressive disorder [ICD-11: 6A70]		[5]
Fluphenazine	API Info	Schizophrenia [ICD-11: 6A20]		[6]
ICD Disease Classification 08		Nervous system disease	Click to Show/Hide
Morphine	API Info	Anaesthesia [ICD-11: 8E22]		[7]
Oxycodone	API Info	Anaesthesia [ICD-11: 8E22]		[8]
Donepezil	API Info	Alzheimer disease [ICD-11: 8A20]		[9]
ICD Disease Classification 11		Circulatory system disease	Click to Show/Hide
Aspirin	API Info	Myocardial infarction [ICD-11: BA41]		[10]
Verapamil	API Info	Essential hypertension [ICD-11: BA00]		[11]
ICD Disease Classification 13		Digestive system disease	Click to Show/Hide
Bisacodyl	API Info	Irritable bowel syndrome [ICD-11: DD91]		[12]
Cimetidine	API Info	Duodenal ulcer [ICD-11: DA63]		[13]
ICD Disease Classification 15		Musculoskeletal/connective-tissue disease	Click to Show/Hide
Diclofenac	API Info	Knee osteoarthritis [ICD-11: FA01]		[14]
Metaxalone	API Info	Myalgia [ICD-11: FB56]		[15]

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
Oxidoreductase (ORase)
DBT Name: Albendazole monooxygenase (CYP3A4)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Inhibition ratio < 20 % (tested by experiment)		[16]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN

References
1	FDA label for approved quinine from the official website of the U.S. Food and Drug Administration.
2	FDA label for approved glyburide from the official website of the U.S. Food and Drug Administration.
3	FDA label for approved paroxetine from the official website of the U.S. Food and Drug Administration.
4	FDA label for approved lithium carbonate from the official website of the U.S. Food and Drug Administration.
5	FDA label for approved cyclobenzaprine from the official website of the U.S. Food and Drug Administration.
6	FDA label for approved fluphenazine from the official website of the U.S. Food and Drug Administration.
7	FDA label for approved morphine from the official website of the U.S. Food and Drug Administration.
8	Efficacy of oxycodone in neuropathic pain: a randomized trial in postherpetic neuralgia. Neurology. 1998 Jun;50(6):1837-41.
9	FDA label for approved donepezil from the official website of the U.S. Food and Drug Administration.
10	FDA label for approved aspirin from the official website of the U.S. Food and Drug Administration.
11	FDA label for approved verapamil from the official website of the U.S. Food and Drug Administration.
12	FDA label for approved bisacodyl from the official website of the U.S. Food and Drug Administration.
13	FDA label for approved cimetidine from the official website of the U.S. Food and Drug Administration.
14	FDA label for approved diclofenac from the official website of the U.S. Food and Drug Administration.
15	FDA label for approved metaxalone from the official website of the U.S. Food and Drug Administration.
16	Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.

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