Details of the Active Pharmaceutical Ingredient (API)
General Information of API (ID: D00404) | |||||
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Name |
Metaxalone
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Synonyms |
Click to Show/Hide the Synonyms of This API
METAXALONE; 1665-48-1; Skelaxin; Methaxalonum; Zorane; Metaxalon; Methoxolone; 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one; Metazalone; Metazolone; Metaxolone; AHR-438; 2-Oxazolidinone, 5-[(3,5-dimethylphenoxy)methyl]-; Metaxalonum [Latin]; Metassalone [DCIT]; 5-[(3,5-Dimethylphenoxy)methyl]-1,3-oxazolidin-2-one; Metaxalonum [INN-Latin]; Metaxalona [INN-Spanish]; AHR 438; 5-(3,5-Xyloloxymethyl)oxazolidin-2-one; CL 39,148; 2-Oxazolidinone, 5-((3,5-xylyloxy)methyl)-; NSC 170959; 5-[(3,5-Xylyloxy)methyl]-2-oxazolidinone; 5-((3,5-Dimethylphenoxy)methyl)-2-oxazolidinone; 5-[(3,5-dimethylphenoxy)methyl]oxazolidin-2-one; 5-((3,5-Xylyloxy)methyl)-2-oxazolidinone; MFCD00867700; MLS003106749; CHEBI:6797; 5-[(3,5-Dimethylphenoxy)methyl]-2-oxazolidinone; 2-Oxazolidinone, 5-((3,5-dimethylphenoxy)methyl)-; NSC170959; NSC-170959; NCGC00095116-01; DSSTox_CID_3269; 2-Oxazolidinone, 5-[(3,5-xylyloxy)methyl]-; 5-(3,5-dimethylphenoxymethyl)-2-oxazolidinone; DSSTox_RID_76949; DSSTox_GSID_23269; 5-(3,5-dimethylphenoxymethyl)-1,3-oxazolidin-2-one; Metaxalona [Spanish]; Metassalone; Metaxalona; Metaxalonum; CAS-1665-48-1; Metaxalone [USAN:INN:BAN]; HSDB 3236; SR-05000001978; EINECS 216-777-6; 5-((3,5-Dimethylphenoxy)methyl)-1,3-oxazolidin-2-one; BRN 0884592; .meta.Xalone; .meta.Zalone; .meta.Zolone; .meta.Xalon; Metaxalone solution; Skelaxin (TN); Spectrum_001741; SpecPlus_000656; Metaxalone (USP/INN); Spectrum2_000548; Spectrum3_001666; Spectrum4_000612; Spectrum5_001685; Oprea1_438855; SCHEMBL34908; BSPBio_003451; KBioGR_001164; KBioSS_002221; DivK1c_006752; SPECTRUM1504229; SPBio_000595; GTPL7609; CHEMBL1079604; DTXSID3023269; Metaxalone, >=98% (HPLC); KBio1_001696; KBio2_002221; KBio2_004789; KBio2_007357; KBio3_002671; HMS1922H07; HMS2093C22; Pharmakon1600-01504229; BCP28377; HY-B0678; Tox21_111428; WLN: T5MVOTJ D1OR C1 E1; 2-Oxazolidinone,5-xylyloxy)methyl]-; CCG-39592; NSC758703; STL450994; STL451511; AKOS009035315; Tox21_111428_1; DB00660; FS-3218; MCULE-3101469866; NSC-758703; 5-(3,5-xylyloxymethyl)-2-oxazolidone; NCGC00095116-02; NCGC00095116-03; NCGC00095116-05; AK-61006; BR-61006; SMR001821638; SY052772; SBI-0052859.P002; 2-Oxazolidinone,5-dimethylphenoxy)methyl]-; AB0063964; DB-043656; AM20060525; FT-0603568; 5-(3,5-dimethylphenoxy)methyl-2-oxazolidinone; C07934; D00773; S-2010; AB00053284_04; 665M481; A810747; J-010295; Q6823309; SR-05000001978-1; SR-05000001978-3; BRD-A94709349-001-02-6; BRD-A94709349-001-03-4; 5-[(3,5-Dimethylphenoxy)methyl]-1,3-oxazolidin-2-one #; 5-{[(3,5-dimethylphenyl)oxy]methyl}-1,3-oxazolidin-2-one; 5-[(3,5-dimethylphenoxy)methyl]-4,5-dihydro-1,3-oxazol-2-ol; Metaxalone, United States Pharmacopeia (USP) Reference Standard
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Clinical Status |
Approved
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Disease Indication | Myalgia | ICD-11: FB56 | [1] | ||
PubChem CID | |||||
Formula |
C12H15NO3
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Canonical SMILES |
CC1=CC(=CC(=C1)OCC2CNC(=O)O2)C
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InChI |
1S/C12H15NO3/c1-8-3-9(2)5-10(4-8)15-7-11-6-13-12(14)16-11/h3-5,11H,6-7H2,1-2H3,(H,13,14)
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InChIKey |
IMWZZHHPURKASS-UHFFFAOYSA-N
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Click to Show/Hide the Molecular Data (Structure/Property) of This API | |||||
Structure |
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=15459"></iframe>
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3D MOL | 2D MOL | ||||
Physicochemical Properties | Molecular Weight | 221.25 | Topological Polar Surface Area | 47.6 | |
XlogP | 2.2 | Complexity | 247 | ||
Heavy Atom Count | 16 | Rotatable Bond Count | 3 | ||
Hydrogen Bond Donor Count | 1 | Hydrogen Bond Acceptor Count | 3 | ||
Full List of Drug Formulations (DFMs) Containing This API | ||||||
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Metaxalone 800 mg tablet | Click to Show/Hide the Full List of Formulation(s): 17 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Sodium lauryl sulfate; Fd&c red no. 40; Magnesium stearate; Carboxymethylcellulose sodium; Silicon dioxide; Alginic acid; Aluminum oxide; Hydrogenated castor oil
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Dosage Form | Oral Tablet | |||||
Company | California Pharmaceuticals; Lake Eire Medical & Surgical Supply DBA Quality Care Products; Lannett Company; RemedyRepack | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Allura red AC dye | DIG Info | Solute carrier SLCO2B1 (Ki = 4.7 uM) | [2] | |||
Stearic acid | DIG Info | Phosphodiesterase 3A (IC50 = 3.1 uM) | [2] | |||
Sodium lauryl sulfate | DIG Info | Solute carrier SLCO2B1 (Ki = 1.98 uM) | [3] | |||
Allura red AC dye | DIG Info | Solute carrier SLCO2B1 (Ki = 2.59 uM) | [3] | |||
Carboxymethylcellulose sodium | DIG Info | Albendazole monooxygenase (EC50 = 12.6 uM) | [4] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Drug Formulation 2 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Calcium carbonate; Fd&c red no. 40; Sodium stearyl fumarate; Povidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Sodium starch glycolate type a corn
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Dosage Form | Oral Tablet | |||||
Company | Gemini Pharmaceuticals; Solis Generic Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Allura red AC dye | DIG Info | Solute carrier SLCO2B1 (Ki = 4.7 uM) | [2] | |||
Calcium carbonate | DIG Info | Carbonic anhydrase IX (Ki = 8600 nM) | [6] | |||
Allura red AC dye | DIG Info | Solute carrier SLCO2B1 (Ki = 2.59 uM) | [3] | |||
Sodium stearyl fumarate | DIG Info | Leukemia K562 cells (IC50 = 20.2 ug.mL-1) | [7] | |||
Povidone | DIG Info | Cholesterol 25-hydroxylase (IC50 = 78.3 uM) | [4] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Drug Formulation 3 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Calcium carbonate; Fd&c red no. 40; Sodium stearyl fumarate; Silicon dioxide; Hypromellose, unspecified; Microcrystalline cellulose; Povidone, unspecified; Sodium starch glycolate type a potato
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Dosage Form | Oral Tablet | |||||
Company | A-S Medication Solutions | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Allura red AC dye | DIG Info | Solute carrier SLCO2B1 (Ki = 4.7 uM) | [2] | |||
Calcium carbonate | DIG Info | Carbonic anhydrase IX (Ki = 8600 nM) | [6] | |||
Allura red AC dye | DIG Info | Solute carrier SLCO2B1 (Ki = 2.59 uM) | [3] | |||
Sodium stearyl fumarate | DIG Info | Leukemia K562 cells (IC50 = 20.2 ug.mL-1) | [7] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Drug Formulation 4 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Calcium carbonate; Fd&c red no. 40; Sodium stearyl fumarate; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Povidones; Sodium starch glycolate type a potato
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Dosage Form | Oral Tablet | |||||
Company | A-S Medication Solutions; Aidarex Pharmaceuticals; American Health Packaging; Amneal Pharmaceuticals; AvKARE; AvPAK; Blenheim Phamacal; BluePoint Laboratories; Clinical Solutions Wholesale; DirectRX; Lake Eire Medical & Surgical Supply DBA Quality Care Products; Preferred Pharamaceuticals; Proficient Rx | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Allura red AC dye | DIG Info | Solute carrier SLCO2B1 (Ki = 4.7 uM) | [2] | |||
Calcium carbonate | DIG Info | Carbonic anhydrase IX (Ki = 8600 nM) | [6] | |||
Allura red AC dye | DIG Info | Solute carrier SLCO2B1 (Ki = 2.59 uM) | [3] | |||
Sodium stearyl fumarate | DIG Info | Leukemia K562 cells (IC50 = 20.2 ug.mL-1) | [7] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Drug Formulation 5 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Calcium carbonate; Sodium stearyl fumarate; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Povidones; Sodium starch glycolate type a potato
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Dosage Form | Oral Tablet | |||||
Company | RedPharm | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Calcium carbonate | DIG Info | Carbonic anhydrase IX (Ki = 8600 nM) | [6] | |||
Sodium stearyl fumarate | DIG Info | Leukemia K562 cells (IC50 = 20.2 ug.mL-1) | [7] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Drug Formulation 6 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Carminic acid; Magnesium stearate; Calcium alginate; Alginic acid; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Cardinal Health | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Carminic acid | DIG Info | Protein-tyrosine phosphatase 1B (IC50 = 15000 nM) | [8] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Drug Formulation 7 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Magnesium stearate; Acacia; Alginic acid; Sodium starch glycolate type a potato; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Eon Labs; Physicians Total Care; Preferred Pharamaceuticals; Rebel Distributors; St Marys Medical Park Pharmacy; Unit Dose Services | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Allura red AC dye | DIG Info | Solute carrier SLCO2B1 (Ki = 4.7 uM) | [2] | |||
Allura red AC dye | DIG Info | Solute carrier SLCO2B1 (Ki = 2.59 uM) | [3] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Drug Formulation 8 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Magnesium stearate; Acacia; Alginic acid; Sodium starch glycolate type a potato; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | RedPharm | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Allura red AC dye | DIG Info | Solute carrier SLCO2B1 (Ki = 4.7 uM) | [2] | |||
Allura red AC dye | DIG Info | Solute carrier SLCO2B1 (Ki = 2.59 uM) | [3] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Drug Formulation 9 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Magnesium stearate; Acacia; Alginic acid; Sodium starch glycolate type a potato; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | DirectRX | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Allura red AC dye | DIG Info | Solute carrier SLCO2B1 (Ki = 4.7 uM) | [2] | |||
Allura red AC dye | DIG Info | Solute carrier SLCO2B1 (Ki = 2.59 uM) | [3] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Drug Formulation 10 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Magnesium stearate; Acacia; Alginic acid; Sodium starch glycolate type a potato; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Northwind Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Allura red AC dye | DIG Info | Solute carrier SLCO2B1 (Ki = 4.7 uM) | [2] | |||
Allura red AC dye | DIG Info | Solute carrier SLCO2B1 (Ki = 2.59 uM) | [3] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Drug Formulation 11 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Ferric oxide red; Sodium alginate; Alginic acid; Copovidone; Povidones; Starch, pregelatinized corn
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Dosage Form | Oral Tablet | |||||
Company | Dr Reddy's Laboratories; ScieGen Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Sodium alginate | DIG Info | Albendazole monooxygenase (Inhibition ratio < 20 %) | [9] | |||
Drug Formulation 12 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Ammonium alginate; Calcium alginate; Alginic acid; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Actavis Pharma; Preferred Pharamaceuticals; RemedyRepack; St Marys Medical Park Pharmacy | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Drug Formulation 13 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Calcium alginate; Alginic acid; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | A-S Medication Solutions; Bryant Ranch Prepack; Carilion Materials Management; CorePharma; DirectRX; PD-Rx Pharmaceuticals; Preferred Pharamaceuticals; RemedyRepack; Stat Rx USA; Unit Dose Services | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Drug Formulation 14 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Alginic acid; Calcium; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Physicians Total Care; Preferred Pharamaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Drug Formulation 15 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Alginic acid; Calcium; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Blenheim Phamacal; Dispensing Solution; H. J. Harkins Company; Lake Eire Medical & Surgical Supply DBA Quality Care Products; Rebel Distributors; St Marys Medical Park Pharmacy; Stat Rx USA | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Drug Formulation 16 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Alginic acid; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Lake Eire Medical & Surgical Supply DBA Quality Care Products | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Drug Formulation 17 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Alginic acid; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Keltman Pharmaceuticals; Stat Rx USA | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Metaxalone 400 mg tablet | Click to Show/Hide the Full List of Formulation(s): 1 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c yellow no. 6; Magnesium stearate; Povidone k30; Alginic acid; Propylene glycol alginate
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Dosage Form | Oral Tablet | |||||
Company | CorePharma | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Sunset yellow FCF | DIG Info | Solute carrier SLCO2B1 (Ki = 68.4 uM) | [3] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
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