Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00080)
Name
Budesonide
Synonyms    Click to Show/Hide the Synonyms of This API
budesonide; Entocort; 51333-22-3; Preferid; Pulmicort; Rhinocort Aqua; Rhinocort; Entocort EC; Pulmicort Respules; Budesonidum; Uceris; Budeson; Pulmicort Flexhaler; Cortivent; Micronyl; Respules; Spirocort; Bidien; Budenofalk; CHEBI:3207; MAP-0010; 51372-29-3; MLS000028507; Budesonide MMX; Rhinocort alpha; 16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione; S-1320; Budesonido; SMR000058337; Budecort Inhaler; 16A(R),17-(BUTYLIDENEBIS(OXY))-11B,21-DIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE; Budesonidum [INN-Latin]; Budesonido [INN-Spanish]; (R)-Budesonide; Inflammide; Budiair; Miflonide; Pulmaxan; Fvolir; Budesonide [USAN:INN:BAN:JAN]; Rhinocort Allergy; Pulmaxan turbohaler; Pulmicort (TN); Pulmicort Topinasal; Rhinocort (TN); Pulmicort turbuhaler; Budesonide Easyhaler; S 1320; CCRIS 5230; Entocort EC (TN); SR-01000000101; EINECS 257-139-7; Jorveza; Eltair; Ultesa; Giona Easyhaler; 16?,17-[(1RS)-Butylidenebis(oxy)]-11?,21-dihydroxypregna-1,4-diene-3,20-dione; Prestwick_840; MFCD00083259; Uceris (TN); Budesonide, >=99%; Opera_ID_1696; Prestwick0_000518; Prestwick1_000518; Prestwick2_000518; Prestwick3_000518; Epitope ID:161750; B 7777; SCHEMBL4096; CHEMBL1370; Lopac0_000174; BSPBio_000475; Budesonide (JAN/USP/INN); MLS001077323; MLS002207112; SPBio_002396; BPBio1_000523; GTPL7434; DTXSID8020202; HSDB 8279; MAP0010; R01AD05; HMS1569H17; HMS2096H17; HMS2232D17; HMS3259H07; HMS3260D09; HMS3413B08; HMS3413P17; HMS3677B08; HMS3677P17; HMS3713H17; ACT03247; BCP05589; Tox21_500174; BDBM50354850; AKOS015969655; AB03148; AC-4697; ACN-043365; CCG-204269; CS-2063; DB01222; KS-1162; LP00174; NC00626; SDCCGSBI-0050162.P002; NCGC00021318-05; NCGC00021318-06; NCGC00021318-08; NCGC00021318-18; NCGC00089747-04; NCGC00260859-01; Budesonide 100 microg/mL in Acetonitrile; CPD000058337; HY-13580; EU-0100174; 5301-EP2270008A1; 5301-EP2280006A1; 5301-EP2281563A1; 5301-EP2281813A1; 5301-EP2281815A1; 5301-EP2281819A1; 5301-EP2292617A1; 5301-EP2292619A1; 5301-EP2295402A2; 5301-EP2295408A1; 5301-EP2301933A1; 5301-EP2305640A2; 5301-EP2305659A1; 5301-EP2308562A2; 5301-EP2311818A1; 5301-EP2311827A1; 5301-EP2314590A1; 5301-EP2316459A1; 5301-EP2371811A2; D00246; 333B223; Q422212; J-504150; Q-101375; SR-01000000101-2; SR-01000000101-6; BRD-A34299591-001-03-4; Budesonide, European Pharmacopoeia (EP) Reference Standard; Budesonide, United States Pharmacopeia (USP) Reference Standard; Budesonide, Pharmaceutical Secondary Standard; Certified Reference Material; (11?,16?)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione
Clinical Status
Approved
Disease Indication Allergic rhinitis ICD-11: CA08 [1]
PubChem CID
5281004
Formula
C25H34O6
Canonical SMILES
CCCC1O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@@]5([C@H]4[C@H](C[C@@]3([C@@]2(O1)C(=O)CO)C)O)C
InChI
1S/C25H34O6/c1-4-5-21-30-20-11-17-16-7-6-14-10-15(27)8-9-23(14,2)22(16)18(28)12-24(17,3)25(20,31-21)19(29)13-26/h8-10,16-18,20-22,26,28H,4-7,11-13H2,1-3H3/t16-,17-,18-,20+,21?,22+,23-,24-,25+/m0/s1
InChIKey
VOVIALXJUBGFJZ-KWVAZRHASA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5281004"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 430.5 Topological Polar Surface Area 93.1
XlogP 2.5 Complexity 862
Heavy Atom Count 31 Rotatable Bond Count 4
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 6
Full List of Drug Formulations (DFMs) Containing This API
          Budesonide 3 mg capsule Click to Show/Hide the Full List of Formulation(s):        13 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Fd&c blue no. 2; Magnesium stearate; Acetyltributyl citrate; Ferrosoferric oxide; Propylene glycol; Sodium hydroxide; Talc; Titanium dioxide; Triethyl citrate; Crospovidone; Polysorbate 80; Silicon dioxide; Dimethicone; Ethylcelluloses; Gelatin; Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company Carilion Materials Management
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Acetic acid; D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Fd&c blue no. 2; Fd&c yellow no. 6; Indigotindisulfonate sodium; Acetyltributyl citrate; Ferrosoferric oxide; Propylene glycol; Sodium hydroxide; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Dimethicone; Ethylcelluloses; Gelatin, unspecified; Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Shellac; Starch, corn
                   Dosage Form Delayed Release Oral Capsule
                   Company Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Acetic acid DIG Info Free fatty acid receptor 3 (EC50 = 12000 nM) [6]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Fd&c blue no. 2; Magnesium stearate; Acetyltributyl citrate; Ferrosoferric oxide; Propylene glycol; Sodium hydroxide; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Silicon dioxide; Crospovidone (15 mpa.s at 5%); Dimethicone; Ethylcellulose, unspecified; Gelatin, unspecified; Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company Golden State Medical Supply
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Fd&c blue no. 2; Magnesium stearate; Acetyltributyl citrate; Ferrosoferric oxide; Propylene glycol; Sodium hydroxide; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Silicon dioxide; Crospovidone (15 mpa.s at 5%); Dimethicone; Ethylcelluloses; Gelatin; Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Fd&c blue no. 2; Magnesium stearate; Acetyltributyl citrate; Ferrosoferric oxide; Propylene glycol; Sodium hydroxide; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Silicon dioxide; Crospovidone (15 mpa.s at 5%); Dimethicone; Ethylcellulose, unspecified; Gelatin, unspecified; Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 28; Sodium lauryl sulfate; D&c yellow no. 10; Fd&c red no. 40; D&c red no. 33; Fd&c blue no. 1; Fd&c blue no. 2; Acetyltributyl citrate; Ferrosoferric oxide; Propylene glycol; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Ethylcellulose (10 mpa.s); Gelatin, unspecified; Hypromellose, unspecified; Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Polyethylene glycol, unspecified; Shellac; Starch, corn
                   Dosage Form Delayed Release Oral Capsule
                   Company Mayne Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 33 DIG Info Solute carrier SLCO2B1 (Ki = 58.1 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Cetyl alcohol; Ethyl acrylate; Acetyltributyl citrate; Ammonia; Ferric oxide red; Ferrosoferric oxide; Potassium hydroxide; Propylene glycol; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Water; Polysorbate 80; Ethylcelluloses; Gelatin; Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Shellac; Starch, corn
                   Dosage Form Delayed Release Oral Capsule
                   Company Alvogen
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Ethyl acrylate DIG Info NFE2-related factor 2 (EC50 = 5110 nM) [7]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Cetyl alcohol DIG Info Breast cancer FM3A cells (EC50 = 1600 nM) [8]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Butyl alcohol; Isopropyl alcohol; Acetyltributyl citrate; Ammonia; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Potassium hydroxide; Propylene glycol; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Water; Polysorbate 80; Alcohol; Dimethicone; Ethylcelluloses; Gelatin; Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company Cadila Healthcare; Zydus Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [10]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Acetyltributyl citrate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Silicon dioxide; Gelatin; Methacrylic acid
                   Dosage Form Delayed Release Oral Capsule
                   Company AstraZeneca
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Acetyltributyl citrate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Ethylcelluloses; Gelatin; Methacrylic acid
                   Dosage Form Delayed Release Oral Capsule
                   Company Par Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Acetyltributyl citrate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Colloidal silicon dioxide; Gelatin; Methacrylic acid
                   Dosage Form Delayed Release Oral Capsule
                   Company Physicians Total Care; Prometheus Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Acetyltributyl citrate; Ferric oxide red; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Ethylcelluloses; Gelatin; Methacrylic acid - ethyl acrylate copolymer (1:1) type a
                   Dosage Form Delayed Release Oral Capsule
                   Company Paddock Laboratories,
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Acetyltributyl citrate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Potassium hydroxide; Sodium hydroxide; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Ethylcelluloses; Gelatin; Methacrylic acid; Shellac; Starch, corn
                   Dosage Form Delayed Release Oral Capsule
                   Company Appco Pharma; Rising Pharmaceuticals
          Budesonide 9 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose, unspecified form; Magnesium stearate; Talc; Titanium dioxide; Triethyl citrate; Hydroxypropyl cellulose (80000 mw); Lecithin, soybean; Silicon dioxide; Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Microcrystalline cellulose
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Santarus
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Hydroxypropyl cellulose DIG Info Mephenytoin 4-hydroxylase (EC50 = 89.5 uM) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Soybean lecithin DIG Info Albendazole monooxygenase (IC50 = 6.61 mg.mL-1) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
References
1 FDA label for approved budesonide from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
4 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
5 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
6 Microbiota-Host Transgenomic Metabolism, Bioactive Molecules from the Inside. J Med Chem. 2018 Jan 11; 61(1):47-61.
7 A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model. Eur J Med Chem. 2020 Jan 1; 185:111777.
8 Synthesis and notable antimalarial activity of acyclic peroxides, L-(alkyldioxy)-L-(methyldioxy)cyclododecanes. J Med Chem. 2002 Mar 14; 45(6):1374-8.
9 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
10 Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoprotein. J Med Chem. 2004 Mar 11; 47(6):1413-22.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.