Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00177)
Name
Dextromethorphan
Synonyms    Click to Show/Hide the Synonyms of This API
dextromethorphan; d-Methorphan; delta-Methorphan; Dextromorphan; Dextromethorfan; Delsym; Destrometerfano; Dextrometorfano; Albutussin; 125-71-3; Dextromethorphane; Dextromethorphanum; BA 2666; Benylin DM; HSDB 3056; Dextromethorfan [Czech]; Destrometerfano [DCIT]; 3-Methoxy-17-methyl-9alpha,13alpha,14alpha-morphinan; UNII-7355X3ROTS; Dextrometorphan; Romilar; Morphinan, 3-methoxy-17-methyl-, (9alpha,13alpha,14alpha)-; Dextrometorfano [INN-Spanish]; (+)-3-Methoxy-17-methylmorphinan; 7355X3ROTS; Balminil DM; Dextromethorphane [INN-French]; Dextromethorphanum [INN-Latin]; Dextromethorphan [USP:INN:BAN]; (1S,9S,10S)-4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene; DXM [Antitussive]; (+)-Dextromethorphan; ( )-3-Methoxy-N-methylmorphinon; Dextromethorphan (USP); EINECS 204-752-2; CHEBI:4470; BRN 0088549; Calmylin; Nodex; Morphinan, 3-methoxy-17-methyl-, (9.alpha.,13.alpha.,14.alpha.)-; (+)-3-Methoxy-N-methylmorphinon; Delsym (Salt/Mix); Medicon (Salt/Mix); Romilar (Salt/Mix); Tusilan (Salt/Mix); 9alpha,13alpha,14alpha-Morphinan, 3-methoxy-17-methyl-; Prestwick0_000359; Prestwick1_000359; Prestwick2_000359; Prestwick3_000359; Lopac-D-2531; Racemethorphan [as d-form]; ( )-cis-1,3,4,9,10,10a-Hexahydro-6-methoxy-11-methyl-2H-10,4alpha-iminoethanophenanthren; SCHEMBL29949; BSPBio_000457; 4-21-00-01367 (Beilstein Handbook Reference); CHEMBL52440; SPBio_002378; BPBio1_000503; GTPL6953; (9alpha,13alpha,14alpha)-3-Methoxy-17-methylmorphinan; DTXSID3022908; CHEBI:92579; (+)-3-methoxy-n-methylmorphinan; (9alpha,13alpha,14alpha)-17-methyl-3-(methyloxy)morphinan; 9-alpha,13-alpha,14-alpha-Morphinan, 3-methoxy-17-methyl-; HMS2090C08; LSM-2726; Morphinan, 3-methoxy-17-methyl-, (9-alpha,13-alpha,14-alpha)-; ZINC3201907; BDBM50366613; AKOS025311415; BA-2666; DB00514; (+)-cis-1,3,4,9,10,10a-Hexahydro-6-methoxy-11-methyl-2H-10,4alpha-iminoethanophenanthren; NCGC00015333-01; NCGC00015333-02; (14alpha)-3-Methoxy-17-methylmorphinan; 3-Methoxy-17-methyl-9a,13a,14a-morphinan; (9a,13a,14a)-3-Methoxy-17-methylmorphinan; C06947; D03742; Q407781; 3-Methoxy-17-methyl-9.alpha.,13.alpha.-morphinan; J-005274; BRD-K33211335-337-03-7; (+)-3-methoxy-17-methyl-9alpha,13alpha,14alpha-morphinan; UNII-8YB8F78WM1 component MKXZASYAUGDDCJ-NJAFHUGGSA-N; 3-Methoxy-17-methyl-9.alpha.,13.alpha.,14.alpha.-morphinan; 9.alpha.,13.alpha.,14.alpha.-Morphinan, 3-methoxy-17-methyl-; 9alpha,13alpha,14alpha-Morphinan, 3-methoxy-17-methyl- (8CI); 3-Methoxy-17-methylmorphinan-, (9.alpha.,13.alpha.,14.alpha.)- #; 4-methoxy-12-methyl-12-azatetracyclo[9.3^1.10^.0^2.7^] heptadeca-2(7),3,5-triene; (1R,9R,10R)-4-methoxy-17-methyl-17-azatetracyclo[7.5.3.0^{1,10}.0^{2,7}]heptadeca-2,4,6-triene; (4aS,10S,10aS)-6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene; Dextromethorphan solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material
Clinical Status
Approved
Disease Indication Allergic conjunctivitis ICD-11: 9A60 [1]
PubChem CID
5360696
Formula
C18H25NO
Canonical SMILES
CN1CC[C@@]23CCCC[C@@H]2[C@@H]1CC4=C3C=C(C=C4)OC
InChI
1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1
InChIKey
MKXZASYAUGDDCJ-NJAFHUGGSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5360696"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 271.4 Topological Polar Surface Area 12.5
XlogP 3.4 Complexity 370
Heavy Atom Count 20 Rotatable Bond Count 1
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 2
Full List of Drug Formulations (DFMs) Containing This API
          Dextromethorphan 30 mg tablet Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Maltodextrin; Sucralose; Magnesium stearate; Mannitol; Citric acid monohydrate; Talc; Crospovidone; Polysorbate 80; Silicon dioxide; Aluminum oxide; Cellulose, microcrystalline; Diacetylated monoglycerides; Sodium polystyrene sulfonate; Starch, corn
                   Dosage Form Disintegrating Oral Tablet
                   Company Matrixx Initiatives
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
Sucralose DIG Info Carbonic anhydrase II (Ki = 300 nM) [3]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [4]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [5]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sucralose; Fd&c blue no. 2; Fd&c yellow no. 5; Magnesium stearate; Mannitol; Citric acid monohydrate; Talc; Crospovidone; Polysorbate 80; Silicon dioxide; Acacia; Aluminum oxide; Cellulose, microcrystalline; Diacetylated monoglycerides; Sodium polystyrene sulfonate
                   Dosage Form Disintegrating Oral Tablet
                   Company Matrixx Initiatives
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sucralose DIG Info Carbonic anhydrase II (Ki = 300 nM) [3]
Hydrazine yellow DIG Info GABA(A) receptor alpha-1 (IC50 = 13 uM) [2]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [4]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
          Dextromethorphan 15 mg capsule Click to Show/Hide the Full List of Formulation(s):        14 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Mannitol; Propyl gallate; Sorbitol; Glycerin; Propylene glycol; Water; Medium-chain triglycerides; Polyethylene glycol 400; Gelatin; Povidone k12
                   Dosage Form Oral Capsule
                   Company Richmond Division of Wyeth
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [5]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [4]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [5]
Propyl gallate DIG Info Arachidonate 5-lipoxygenase (Ki = 0.43 uM) [2]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [8]
Medium-chain triglyceride DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 36 %) [7]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [8]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Sorbitol; Glycerin; Propylene glycol; Water; Polyethylene glycol 400; Povidone; Gelatin
                   Dosage Form Oral Capsule
                   Company Humanwell PuraCap Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [5]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [5]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [8]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [8]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Sorbitol; Glycerin; Propylene glycol; Water; Polyethylene glycol 400; Povidone; Gelatin
                   Dosage Form Oral Capsule
                   Company Spirit Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [5]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [5]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [8]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [8]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Sorbitol; Glycerin; Propylene glycol; Water; Polyethylene glycol 400; Povidone k30; Gelatin; Sorbitan
                   Dosage Form Oral Capsule
                   Company Chain Drug Consortium
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [5]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [5]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [8]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [8]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Sorbitol; Glycerin; Propylene glycol; Titanium dioxide; Water; Polyethylene glycol 400; Gelatin; Povidones
                   Dosage Form Oral Capsule
                   Company J.P Business Enterprise; Spirit Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [5]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [5]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [8]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [8]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Sorbitol; Glycerin; Propylene glycol; Water; Povidone; Gelatin; Mineral oil; Polyethylene glycols
                   Dosage Form Oral Capsule
                   Company Rugby Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [5]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [5]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [8]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Sorbitol; Glycerin; Propylene glycol; Water; Povidone; Gelatin; Mineral oil
                   Dosage Form Oral Capsule
                   Company Army & Air Force Exchange Service
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [5]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [5]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [8]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Sorbitol; Glycerin; Propylene glycol; Water; Povidone; Gelatin; Polyethylene glycols; Sorbitan
                   Dosage Form Oral Capsule
                   Company Chain Drug Marketing Association
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [5]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [5]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [8]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Sorbitol; Glycerin; Propylene glycol; Water; Povidone; Gelatin; Polyethylene glycols
                   Dosage Form Oral Capsule
                   Company PuraCap Pharmaceutical; Topco Associates
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [5]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [5]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [8]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Sorbitol; Glycerin; Propylene glycol; Povidone; Gelatin; Mineral oil; Polyethylene glycols
                   Dosage Form Oral Capsule
                   Company Amerisource Bergen
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [5]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [5]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [8]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Sorbitol; Glycerin; Propylene glycol; Titanium dioxide; Water; Povidone; Gelatin; Polyethylene glycols; Sorbitan
                   Dosage Form Oral Capsule
                   Company Greenbrier International
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [5]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [8]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Sorbitol; Glycerin; Propylene glycol; Water; Gelatin; Mineral oil; Polyethylene glycol, unspecified; Povidone, unspecified
                   Dosage Form Oral Capsule
                   Company CVS Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [5]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [5]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [8]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Sorbitol; Glycerin; Propylene glycol; Water; Gelatin, unspecified; Mineral oil; Polyethylene glycol, unspecified; Povidone, unspecified
                   Dosage Form Oral Capsule
                   Company L&R Distributors; Walgreens Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [5]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [5]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [8]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Sorbitol; Water
                   Dosage Form Oral Capsule
                   Company Army & Air Force Exchange Service; L&R Distributors; Major Pharmaceuticals; Rite Aid; Walgreens Company; Woonsocket Prescription Center
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [5]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [5]
          Dextromethorphan 15mg/5ml Syrup Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Artificial; Natural Flavors; Citric Acid; D&C Red 33; D&C Yellow 10; Fd&C Blue 1; Fd&C Yellow 6; Glycerin; Saccharin Sodium; Sodium Benzoate; Sodium Citrate; Sodium Propionate; Water
                   Dosage Form Syrup
                   Company Ani Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium citrate anhydrous DIG Info Carbonic anhydrase IV (Ki = 99 nM) [10]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [5]
D&C red no. 33 DIG Info Solute carrier SLCO2B1 (Ki = 58.1 uM) [5]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [5]
Kyselina citronova DIG Info Perilipin-1 (IC50 = 3708 nM) [11]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Saccharin sodium anhydrous DIG Info Carbonic anhydrase I (Ki = 18540 nM) [12]
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [10]
          Dextromethorphan 10mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Croscarmellose Sodium Nf; Microcrystalline Cellulose Nf; Colloidal Silicon Dioxide Nf; Lactose Monohydrate Nf; Magnesium Stearate Nf
                   Dosage Form Capsule
                   Company Avanir Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
          Dextromethorphan 20mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Croscarmellose Sodium Nf; Microcrystalline Cellulose Nf; Colloidal Silicon Dioxide Nf; Lactose Monohydrate Nf; Magnesium Stearate Nf
                   Dosage Form Capsule
                   Company Avanir Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
References
1 FDA label for approved dextromethorphan from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Sweet Binders: Carbonic Anhydrase IX in Complex with Sucralose. ACS Med Chem Lett. 2018 May 10; 9(7):657-661.
4 Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective. Bioorg Med Chem Lett. 2017 Jun 1; 27(11):2239-2258.
5 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
6 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
7 Interactions between human multidrug resistance related protein (MRP2; ABCC2) and excipients commonly used in self-emulsifying drug delivery systems (SEDDS). Int J Pharm. 2013 Apr 15;447(1-2):192-8.
8 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
9 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
10 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):573-8.
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