Details of the Drug Inactive Ingredient (DIG)
Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG | ||||||
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ICD Disease Classification 01 | Infectious/parasitic disease | Click to Show/Hide | ||||
Crofelemer
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API Info |
Human immunodeficiency virus infection [ICD-11: 1C60]
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[1] | |||
ICD Disease Classification 05 | Endocrine/nutritional/metabolic disease | Click to Show/Hide | ||||
Omega-3 carboxylic acid
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API Info |
Hypertriglyceridaemia [ICD-11: 5C80]
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[2] | |||
ICD Disease Classification 08 | Nervous system disease | Click to Show/Hide | ||||
Valproic acid
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API Info |
Epilepsy [ICD-11: 8A60]
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[3] | |||
Tizanidine
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API Info |
Tic disorder [ICD-11: 8A05]
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[4] | |||
ICD Disease Classification 11 | Circulatory system disease | Click to Show/Hide | ||||
Diltiazem
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API Info |
Essential hypertension [ICD-11: BA00]
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[5] | |||
Nifedipine
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API Info |
Angina pectoris [ICD-11: BA40]
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[6] | |||
ICD Disease Classification 12 | Respiratory system disease | Click to Show/Hide | ||||
Budesonide
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API Info |
Allergic rhinitis [ICD-11: CA08]
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[7] | |||
ICD Disease Classification 15 | Musculoskeletal/connective-tissue disease | Click to Show/Hide | ||||
Flavoxate
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API Info |
Knee osteoarthritis [ICD-11: FA01]
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[8] | |||
ICD Disease Classification 16 | Genitourinary system disease | Click to Show/Hide | ||||
Tolterodine
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API Info |
Overactive bladder [ICD-11: GC50]
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[9] | |||
Full List of Biological Targets of DIG (DBTs) Regulated by This DIG | ||||||
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Other protein families (OPF) | ||||||
DBT Name: NFE2-related factor 2 (NRF2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | EC50 = 5110 nM (estimated based on the structural similarity with CHEMBL2107333 ) | [10] | ||||
Structural Similarity | Tanimoto coefficient = 0.837837838 | |||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | NF2L2_HUMAN | |||||
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