Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00277)
Name
Flavoxate
Synonyms    Click to Show/Hide the Synonyms of This API
flavoxate; 15301-69-6; Flavoxato; Flavoxatum; 2-(piperidin-1-yl)ethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate; UNII-3E74Y80MEY; 4H-1-Benzopyran-8-carboxylic acid, 3-methyl-4-oxo-2-phenyl-, 2-(1-piperidinyl)ethyl ester; 2-piperidin-1-ylethyl 3-methyl-4-oxo-2-phenylchromene-8-carboxylate; 2-piperidinoethyl 3-methylflavone-8-carboxylate; Spasuret hydrochloride; 3E74Y80MEY; CHEBI:5088; 2-(1-Piperidinyl)ethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate; 2-Piperidinoethyl 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylate; beta-piperidinoethyl 3-methylflavone-8-carboxylate; Flavossato [DCIT]; Flavossato; AK 123; Flavoxate [INN:BAN]; Flavoxate HCI; Flavoxatum [INN-Latin]; Flavoxato [INN-Spanish]; Flavoxate (INN); Bladuril (TN); NSC114649; NCGC00016636-01; EINECS 239-337-5; CAS-3717-88-2; 2-Piperidinoethyl 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylat; Prestwick0_000242; Prestwick1_000242; Prestwick2_000242; Prestwick3_000242; Piperidinoethyl-3-methylflavone-8-carboxylate; CHEMBL1493; Oprea1_293788; SCHEMBL25801; BSPBio_000024; SPBio_002243; BPBio1_000028; GTPL7187; DTXSID3023053; SPIUTQOUKAMGCX-UHFFFAOYSA-; BML-278; ZINC608382; 1-Piperidinoethanol, 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylate; 2-piperidin-1-ylethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate; AKOS015967074; DB01148; NCGC00016636-02; NCGC00016636-03; FT-0705368; A12900; C07809; D07961; 179987-EP2269989A1; 179987-EP2272832A1; L001104; Q848264; W-108042; BRD-K47639036-003-03-3; 2-(1-piperidyl)ethyl 3-methyl-4-oxo-2-phenyl-chromene-8-carboxylate; 2-Piperidinoethyl-3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylate; 2-(1-Piperidinyl)ethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate #
Clinical Status
Approved
Disease Indication Knee osteoarthritis ICD-11: FA01 [1]
PubChem CID
3354
Formula
C24H25NO4
Canonical SMILES
CC1=C(OC2=C(C1=O)C=CC=C2C(=O)OCCN3CCCCC3)C4=CC=CC=C4
InChI
1S/C24H25NO4/c1-17-21(26)19-11-8-12-20(23(19)29-22(17)18-9-4-2-5-10-18)24(27)28-16-15-25-13-6-3-7-14-25/h2,4-5,8-12H,3,6-7,13-16H2,1H3
InChIKey
SPIUTQOUKAMGCX-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=3354"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 391.5 Topological Polar Surface Area 55.8
XlogP 4.3 Complexity 631
Heavy Atom Count 29 Rotatable Bond Count 6
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 5
Full List of Drug Formulations (DFMs) Containing This API
          Flavoxate 100 mg tablet Click to Show/Hide the Full List of Formulation(s):          5 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Ethyl acrylate; Magnesium stearate; Methyl methacrylate; Silicon dioxide; Cellulose, microcrystalline; Hypromellose 2910 (6 mpa.s); Hypromelloses; Nonoxynol-100; Polyethylene glycols; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Carilion Materials Management; Paddock Laboratories,
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Ethyl acrylate DIG Info NFE2-related factor 2 (EC50 = 5110 nM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Dibasic calcium phosphate dihydrate; Titanium dioxide; Triacetin; Silicon dioxide; Hypromellose phthalate (24% phthalate, 55 cst); Polydextrose; Starch, corn
                   Dosage Form Oral Tablet
                   Company AvPAK; Golden State Medical Supply
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Calcium phosphate, dibasic, dihydrate; Titanium dioxide; Triacetin; Silicon dioxide; Hypromellose 2910 (50 mpa.s); Polydextrose; Polyethylene glycol 8000; Starch, corn
                   Dosage Form Oral Tablet
                   Company Epic Pharma; PuraCap Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Dibasic calcium phosphate dihydrate; Titanium dioxide; Triacetin; Silicon dioxide; Hypromelloses; Polydextrose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Physicians Total Care; TAGI Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Dibasic calcium phosphate dihydrate; Polyethylene glycol 400; Cellacefate; Hypromellose 2910 (6 cps); Starch, corn
                   Dosage Form Oral Tablet
                   Company Global Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [5]
          Flavoxate Hydrochloride 100mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Silicon Dioxide; Starch, Corn; Calcium Phosphate, Dibasic, Dihydrate; Magnesium Stearate; Hypromellose 2910; Polydextrose; Polyethylene Glycol 8000; Titanium Dioxide; Triacetin
                   Dosage Form Tablet
                   Company Epic Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
References
1 Agents for treatment of overactive bladder: a therapeutic class review. Proc (Bayl Univ Med Cent). 2007 Jul;20(3):307-14.
2 A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model. Eur J Med Chem. 2020 Jan 1; 185:111777.
3 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
4 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
5 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.

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