General Information of DIG (ID: E0VK1L)
DIG Name	Hydrogenated polyoxyl 40 castor oil
DIG Function	Emulsifying agent; Solubilizing agent; Surfactant

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 02			Benign/in-situ/malignant neoplasm		Click to Show/Hide
Midostaurin		API Info	Mastocytosis [ICD-11: 2A21]			[1]
ICD Disease Classification 05			Endocrine/nutritional/metabolic disease		Click to Show/Hide
Fenofibrate		API Info	Hypertriglyceridaemia [ICD-11: 5C80]			[2]
ICD Disease Classification 08			Nervous system disease		Click to Show/Hide
Entacapone		API Info	Parkinsonism [ICD-11: 8A00]			[3]
ICD Disease Classification 11			Circulatory system disease		Click to Show/Hide
Felodipine		API Info	Essential hypertension [ICD-11: BA00]			[4]
ICD Disease Classification 13			Digestive system disease		Click to Show/Hide
Loperamide		API Info	Irritable bowel syndrome [ICD-11: DD91]			[5]
ICD Disease Classification 15			Musculoskeletal/connective-tissue disease		Click to Show/Hide
Cyclosporin A		API Info	Rheumatoid arthritis [ICD-11: FA20]			[6]

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
Oxidoreductase (ORase)
DBT Name: Cytochrome P450 3A (CYP3A)			Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Protein expression downregulation (tested by experiment)				[7]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN ; CP3A5_HUMAN ; CP3A7_HUMAN ; CP343_HUMAN
DBT Name: Albendazole monooxygenase (CYP3A4)			Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 800 uM (tested by experiment)				[8]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 0.25 mg.mL-1 (tested by experiment)				[9]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
DBT Name: Cytochrome P450 2C9 (CYP2C9)			Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 30 uM (tested by experiment)				[8]
Tested Species	Homo sapiens (Human)
UniProt ID	CP2C9_HUMAN

References
1	FDA label for approved midostaurin from the official website of the U.S. Food and Drug Administration.
2	FDA label for approved fenofibrate from the official website of the U.S. Food and Drug Administration.
3	FDA label for approved entacapone from the official website of the U.S. Food and Drug Administration.
4	FDA label for approved felodipine from the official website of the U.S. Food and Drug Administration.
5	FDA label for approved loperamide from the official website of the U.S. Food and Drug Administration.
6	FDA label for approved cyclosporin A from the official website of the U.S. Food and Drug Administration.
7	Scientific perspectives on extending the provision for waivers of in vivo bioavailability and bioequivalence studies for drug products containing high solubility-low permeability drugs (BCS-Class 3). AAPS J. 2008 Jun;10(2):300-5.
8	Effects of non-ionic surfactants on cytochrome P450-mediated metabolism in vitro. Eur J Pharm Biopharm. 2011 May;78(1):166-72.
9	Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.

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