Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00071)
Name
Bismuth subsalicylate
Synonyms    Click to Show/Hide the Synonyms of This API
BISMUTH SUBSALICYLATE; 14882-18-9; Bismuth oxysalicylate; Bismuth oxide salicylate; Wismutsubsalicylat; 4H-1,3,2-Benzodioxabismin-4-one, 2-hydroxy-; Bismuthi subsalicylas; Bismutum subsalicylicum; Basic bismuth salicylate; Bismuth(III) subsalicylate; pink bismuth; Stabisol; Vismut; Spiromak forte; NCGC00166299-01; Trigastronol; 2-Hydroxy-benzo[1,3,2]dioxabismin-4-one; C7H5BiO4; Bismuth oxysalicylate;Bismuth(III) salicylate basic; 2-hydroxy-2H,4H-benzo[d]1,3-dioxa-2-bismacyclohexan-4-one; Bismuth salicylate, basic; Wismutsalicylat, basisches; Bismuth, oxo(salicylato)-; Bismogenol tosse inj; CCRIS 4751; HSDB 332; Salicylic acid basic bismuth salt; Salicylic acid, bismuth basic salt; EINECS 238-953-1; Bismuth, (2-hydroxybenzoato-O1,O2)oxo-; Bismuth, (2-hydroxybenzoato-O(1),O(2))oxo-; Wismutoxidsalicylat; 2-Hydroxybenzoic acid bismuth (3+) salt, basic; MFCD00085368; Pepto-bismol (TN); Bismuth subsalicylate [USAN:USP:JAN]; (2-Hydroxybenzoato-O(sup 1))-oxobismuth; DSSTox_CID_4622; 2-Hydroxy-4H-1,3,2-benzodioxabismin-4-one; EC 238-953-1; DSSTox_RID_77471; DSSTox_GSID_24622; Bismuth subsalicylate [USAN); MLS000069654; DTXSID6024622; Bismuth subsalicylate (JAN/USP); CHEBI:261649; HMS2093H13; Pharmakon1600-01505412; HY-B0550; Tox21_112398; NSC759117; AKOS015888405; CCG-213424; DB01294; NSC-759117; NCGC00166299-03; 2-hydroxy-1,3,2-benzodioxabismin-4-one; AS-65783; SMR000059234; SBI-0206855.P001; CAS-14882-18-9; C07870; D00728; AB00489978_02; Bismuth, (2-hydroxybenzoato-O1,O2)oxo- (9CI); 2-hydroxy-4H-benzo[d][1,3,2]dioxabismin-4-one; SR-05000001933; J-008518; SR-05000001933-1; Bismuth(III) subsalicylate, 99.9% trace metals basis; Bismuth(III) salicylate basic, purum, >=97.0% (KT); Bismuth subsalicylate, United States Pharmacopeia (USP) Reference Standard; 87-27-4
Clinical Status
Approved
Disease Indication Irritable bowel syndrome ICD-11: DD91 [1]
PubChem CID
16682734
Formula
C7H6BiO4
Canonical SMILES
C1=CC=C2C(=C1)C(=O)O[Bi]O2.O
InChI
1S/C7H6O3.Bi.H2O/c8-6-4-2-1-3-5(6)7(9)10;;/h1-4,8H,(H,9,10);;1H2/q;+2;/p-2
InChIKey
QBWLKDFBINPHFT-UHFFFAOYSA-L
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=16682734"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 363.1 Topological Polar Surface Area 36.5
XlogP N.A. Complexity 173
Heavy Atom Count 12 Rotatable Bond Count 0
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 4
Full List of Drug Formulations (DFMs) Containing This API
          Bismuth subsalicylate 262 mg tablet Click to Show/Hide the Full List of Formulation(s):        44 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Calcium carbonate; D&c red no. 30; Fd&c red no. 40; D&c red no. 27; Magnesium stearate; Mannitol; Talc; Povidone; Saccharin sodium
                   Dosage Form Chewable Tablet
                   Company Greenbrier International; Harmon Stores
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [5]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [6]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [7]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Calcium carbonate; D&c red no. 30; Fd&c red no. 40; D&c red no. 27; Magnesium stearate; Mannitol; Talc; Povidone; Saccharin sodium
                   Dosage Form Chewable Tablet
                   Company Walgreens Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [5]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [6]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [7]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Calcium carbonate; D&c red no. 30; D&c red no. 27; Magnesium stearate; Mannitol; Povidone; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Wal-Mart Stores
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [5]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [7]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Calcium carbonate; D&c red no. 30; D&c red no. 27; Magnesium stearate; Mannitol; Povidone; Silicon dioxide; Starch, corn
                   Dosage Form Oral Tablet
                   Company Walgreens Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [5]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [7]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Calcium carbonate; D&c red no. 30; D&c red no. 27; Magnesium stearate; Mannitol; Povidone; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company H E B
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [5]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [7]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; Fd&c red no. 40; D&c red no. 27; Magnesium stearate; Mannitol; Adipic acid; Talc; Povidone; Aluminum oxide; Saccharin sodium
                   Dosage Form Chewable Tablet
                   Company Procter & Gamble Manufacturing Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
Adipic acid DIG Info Organic anion transporter 1 (Ki = 407.38 nM) [9]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [6]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [7]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Calcium carbonate; D&c red no. 30; Fd&c red no. 40; D&c red no. 27; Magnesium stearate; Mannitol; Talc; Povidone, unspecified; Saccharin sodium
                   Dosage Form Chewable Tablet
                   Company Army & Air Force Exchange Service
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [5]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [6]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Calcium carbonate; D&c red no. 30; Saccharin sodium dihydrate; D&c red no. 27; Magnesium stearate; Mannitol; Talc
                   Dosage Form Chewable Tablet
                   Company Dolgencorp
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Saccharin sodium dihydrate DIG Info Carbonic anhydrase XII (Ki = 633 nM) [10]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [5]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Calcium carbonate; D&c red no. 30; D&c red no. 27; Magnesium stearate; Mannitol; Povidone; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Better Living Brands
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [5]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [7]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; D&c red no. 27; Magnesium stearate; Mannitol; Polysorbate 80; Povidone; Silicon dioxide; Aluminum oxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Procter & Gamble Manufacturing Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [6]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [7]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Calcium carbonate; D&c red no. 30; D&c red no. 27; Magnesium stearate; Mannitol; Talc; Saccharin sodium
                   Dosage Form Chewable Tablet
                   Company Rite Aid
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [5]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Calcium carbonate; D&c red no. 30; Fd&c red no. 40; Magnesium stearate; Mannitol; Talc; D&c red no. 27 aluminum lake; Povidone, unspecified; Saccharin sodium
                   Dosage Form Chewable Tablet
                   Company L&R Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [5]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [6]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; Fd&c red no. 40; D&c red no. 27; Magnesium stearate; Mannitol; Talc; Povidone; Aluminum oxide; Saccharin sodium
                   Dosage Form Chewable Tablet
                   Company Procter & Gamble Manufacturing Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [6]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [7]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Calcium carbonate; D&c red no. 30; Magnesium stearate; Mannitol; Silicon dioxide; D&c red no. 27 aluminum lake; Microcrystalline cellulose; Povidone, unspecified; Starch, corn
                   Dosage Form Oral Tablet
                   Company SuperValu
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [5]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 15 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Calcium carbonate; D&c red no. 30; Magnesium stearate; Mannitol; Silicon dioxide; D&c red no. 27 aluminum lake; Microcrystalline cellulose; Povidone, unspecified; Starch, corn
                   Dosage Form Oral Tablet
                   Company Rite Aid
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [5]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 16 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; D&c red no. 27; Magnesium stearate; Mannitol; Polysorbate 80; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a corn
                   Dosage Form Oral Tablet
                   Company Amerisource Bergen
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [6]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 17 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; Maltodextrin; Aspartame; D&c red no. 27; Magnesium stearate; Silicon dioxide; Acacia; Cellulose, microcrystalline; Dextrates
                   Dosage Form Chewable Tablet
                   Company Moore Medical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [11]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 18 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; Maltodextrin; Aspartame; D&c red no. 27; Magnesium stearate; Silicon dioxide; Acacia; Cellulose, microcrystalline; Dextrates
                   Dosage Form Chewable Tablet
                   Company Unifirst First Aid
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [11]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 19 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; Maltodextrin; Aspartame; D&c red no. 27; Magnesium stearate; Silicon dioxide; Acacia; Cellulose, microcrystalline; Dextrates
                   Dosage Form Chewable Tablet
                   Company Unifirst First Aid
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [11]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 20 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; Maltodextrin; Aspartame; D&c red no. 27; Magnesium stearate; Silicon dioxide; Dextrates; Microcrystalline cellulose
                   Dosage Form Chewable Tablet
                   Company Marc Glassman, Inc.
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [11]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 21 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Sodium lauryl sulfate; Magnesium stearate; Talc; Titanium dioxide; Triacetin; Croscarmellose sodium; Crospovidone; Cellulose, microcrystalline; Hydrated silica; Hypromelloses; Mineral oil; Povidones
                   Dosage Form Oral Tablet
                   Company Chattem
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 22 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; D&c red no. 27; Magnesium stearate; Mannitol; Talc; Povidone; Aluminum oxide; Saccharin sodium
                   Dosage Form Chewable Tablet
                   Company Navajo Manufacturing
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [7]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 23 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; Maltodextrin; D&c red no. 27; Magnesium stearate; Sorbitol; Silicon dioxide; Cherry; Dextrose
                   Dosage Form Chewable Tablet
                   Company Advance Pharmaceutical; CVS Pharmacy; PuraCap Pharmaceutical; Richmond Pharmaceuticals; Rugby Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [11]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 24 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; Maltodextrin; D&c red no. 27; Magnesium stearate; Sorbitol; Silicon dioxide; Dextrose
                   Dosage Form Chewable Tablet
                   Company SDA Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [11]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 25 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; Maltodextrin; D&c red no. 27; Magnesium stearate; Sorbitol; Silicon dioxide; Cherry; Dextrose
                   Dosage Form Chewable Tablet
                   Company Reliable 1 Laboratires
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [11]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 26 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; Maltodextrin; D&c red no. 27; Magnesium stearate; Sorbitol; Silicon dioxide; Dextrose
                   Dosage Form Chewable Tablet
                   Company Rebel Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [11]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 27 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Calcium carbonate; D&c red no. 27; Magnesium stearate; Mannitol; Saccharin sodium
                   Dosage Form Chewable Tablet
                   Company L. Perrigo Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 28 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Calcium carbonate; D&c red no. 27; Magnesium stearate; Mannitol; Saccharin sodium
                   Dosage Form Chewable Tablet
                   Company Dolgencorp; Shopko; Wakefern Food Corporation
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 29 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Calcium carbonate; D&c red no. 27; Magnesium stearate; Mannitol; Saccharin sodium
                   Dosage Form Chewable Tablet
                   Company Kroger Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 30 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; Saccharin sodium dihydrate; D&c red no. 27; Magnesium stearate; Mannitol; Starch, corn
                   Dosage Form Chewable Tablet
                   Company Major Pharmaceuticals; McKesson
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Saccharin sodium dihydrate DIG Info Carbonic anhydrase XII (Ki = 633 nM) [10]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 31 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; Magnesium stearate; Mannitol; Polysorbate 80; Silicon dioxide; Cellulose, microcrystalline; Povidones
                   Dosage Form Oral Tablet
                   Company JC World Bell Wholesale
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [6]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 32 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; Aspartame; D&c red no. 27; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Dextrates
                   Dosage Form Chewable Tablet
                   Company Moore Medical; Unifirst First Aid
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 33 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; Aspartame; D&c red no. 27; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Dextrates
                   Dosage Form Chewable Tablet
                   Company Qualitest Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 34 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; Aspartame; D&c red no. 27; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Dextrates
                   Dosage Form Oral Tablet
                   Company Allegiant Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 35 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; D&c red no. 27; Magnesium stearate; Polysorbate 80; Silicon dioxide; Sodium starch glycolate type a corn
                   Dosage Form Oral Tablet
                   Company CVS Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 36 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Calcium carbonate; D&c red no. 27; Magnesium stearate; Crospovidone; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Target Corporation
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 37 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; D&c red no. 27; Magnesium stearate; Mannitol; Talc; Aluminum oxide; Povidones; Saccharin sodium
                   Dosage Form Chewable Tablet
                   Company Lil Drug Store Products
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 38 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; D&c red no. 27; Magnesium stearate; Mannitol; Saccharin sodium; Starch, corn
                   Dosage Form Chewable Tablet
                   Company Aidarex Pharmaceuticals; Proficient Rx
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 39 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; D&c red no. 27; Magnesium stearate; Mannitol; Saccharin sodium; Starch, pregelatinized corn
                   Dosage Form Chewable Tablet
                   Company Amerisource Bergen; Safeway; WinCo Foods
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 40 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; D&c red no. 27; Magnesium stearate; Mannitol; Saccharin sodium; Starch, corn
                   Dosage Form Chewable Tablet
                   Company Rugby Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 41 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; Aspartame; Magnesium stearate; Silicon dioxide; Dextrates
                   Dosage Form Chewable Tablet
                   Company Preferred Pharamaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 42 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; D&c red no. 27; Magnesium stearate; Polysorbate 80; Colloidal silicon dioxide; Sodium starch glycolate type a corn
                   Dosage Form Oral Tablet
                   Company McKesson
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 43 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sucralose; D&c red no. 27; Magnesium stearate; Sorbitol; Cellulose, microcrystalline
                   Dosage Form Chewable Tablet
                   Company Publix Super Markets
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sucralose DIG Info Carbonic anhydrase II (Ki = 300 nM) [12]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 44 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; Magnesium stearate; Mannitol; Saccharin sodium
                   Dosage Form Chewable Tablet
                   Company Cardinal Health; Publix Super Markets; Topco Associates
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
References
1 Bismuth Subsalicylate.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
4 Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):567-71.
5 PubChem BioAssay data set.
6 Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective. Bioorg Med Chem Lett. 2017 Jun 1; 27(11):2239-2258.
7 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
8 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
9 Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. J Biol Chem. 2007 Aug 17; 282(33):23841-53.
10 Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII. Bioorg Med Chem Lett. 2008 Jan 15; 18(2):836-41.
11 Interactions between human multidrug resistance related protein (MRP2; ABCC2) and excipients commonly used in self-emulsifying drug delivery systems (SEDDS). Int J Pharm. 2013 Apr 15;447(1-2):192-8.
12 Sweet Binders: Carbonic Anhydrase IX in Complex with Sucralose. ACS Med Chem Lett. 2018 May 10; 9(7):657-661.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.