Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0R4JL)
DIG Name
Polysorbate 80
DIG Function
Dispersing agent; Emollient; Emulsifying agent; Plasticizing agent; Solubilizing agent; Surfactant; Suspending agent
Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
       ICD Disease Classification 01 Infectious/parasitic disease Click to Show/Hide
Minocycline
 API Info
Streptococcus bacterial infection [ICD-11: 1C41]
 [1]
Valacyclovir
 API Info
Herpes zoster [ICD-11: 1E91]
 [2]
Metronidazole
 API Info
Amebiasis [ICD-11: 1A36]
 [3]
Ribavirin
 API Info
Viral hepatitis [ICD-11: 1E51]
 [4]
Famciclovir
 API Info
Genital herpes [ICD-11: 1A94]
 [5]
Ethambutol
 API Info
Pulmonary tuberculosis [ICD-11: 1B10]
 [6]
Ciprofloxacin
 API Info
Endocarditis [ICD-11: 1B12]
 [7]
Cefprozil
 API Info
Streptococcus bacterial infection [ICD-11: 1C41]
 [8]
Chloroquine
 API Info
Malaria [ICD-11: 1F40]
 [9]
Entecavir
 API Info
Viral hepatitis [ICD-11: 1E51]
 [10]
Ritonavir
 API Info
Human immunodeficiency virus infection [ICD-11: 1C60]
 [11]
Lamivudine
 API Info
Human immunodeficiency virus infection [ICD-11: 1C60]
 [12]
Primaquine
 API Info
Malaria [ICD-11: 1F40]
 [13]
Valganciclovir
 API Info
Cytomegalovirus infection [ICD-11: 1D82]
 [14]
Hydroxychloroquine
 API Info
Malaria [ICD-11: 1F40]
 [15]
Moxifloxacin
 API Info
Streptococcus bacterial infection [ICD-11: 1C41]
 [16]
Abacavir
 API Info
Human immunodeficiency virus infection [ICD-11: 1C60]
 [17]
Mefloquine
 API Info
Malaria [ICD-11: 1F40]
 [18]
       ICD Disease Classification 02 Benign/in-situ/malignant neoplasm Click to Show/Hide
Bicalutamide
 API Info
Prostate cancer [ICD-11: 2C82]
 [19]
Exemestane
 API Info
Breast cancer [ICD-11: 2C60]
 [20]
Methotrexate
 API Info
Breast cancer [ICD-11: 2C60]
 [21]
Trametinib
 API Info
Melanoma [ICD-11: 2C30]
 [22]
Nystatin
 API Info
Acute lymphoblastic leukemia [ICD-11: 2B33]
 [23]
Venetoclax
 API Info
Chronic lymphocytic leukaemia [ICD-11: 2A82]
 [24]
Lapatinib
 API Info
Breast cancer [ICD-11: 2C60]
 [25]
Anastrozole
 API Info
Breast cancer [ICD-11: 2C60]
 [26]
Pazopanib
 API Info
Renal cell carcinoma [ICD-11: 2C90]
 [27]
       ICD Disease Classification 03 Blood/blood-forming organ disease Click to Show/Hide
Eltrombopag
 API Info
Thrombocytopenia [ICD-11: 3B64]
 [28]
       ICD Disease Classification 04 Immune system disease Click to Show/Hide
Cetirizine
 API Info
Allergy [ICD-11: 4A80]
 [29]
       ICD Disease Classification 05 Endocrine/nutritional/metabolic disease Click to Show/Hide
Fenofibrate
 API Info
Hypertriglyceridaemia [ICD-11: 5C80]
 [30]
Atorvastatin
 API Info
Hyperlipidaemia [ICD-11: 5C8Z]
 [31]
Phentermine
 API Info
Obesity [ICD-11: 5B81]
 [32]
Glipizide
 API Info
Diabetes mellitus [ICD-11: 5A10]
 [33]
Glimepiride
 API Info
Diabetes mellitus [ICD-11: 5A10]
 [34]
Lovastatin
 API Info
Hypertriglyceridaemia [ICD-11: 5C80]
 [35]
Paricalcitol
 API Info
Hyperparathyroidism [ICD-11: 5A51]
 [36]
Metformin
 API Info
Diabetes mellitus [ICD-11: 5A10]
 [37]
Fenofibric acid
 API Info
Dyslipidaemia [ICD-11: 5C81]
 [38]
Benzphetamine
 API Info
Obesity [ICD-11: 5B81]
 [39]
Nateglinide
 API Info
Diabetes mellitus [ICD-11: 5A10]
 [40]
Ergocalciferol
 API Info
Hypoparathyroidism [ICD-11: 5A50]
 [41]
Probenecid
 API Info
Hyperuricaemia [ICD-11: 5C55]
 [42]
Gemfibrozil
 API Info
Hypertriglyceridaemia [ICD-11: 5C80]
 [43]
Cholecalciferol
 API Info
Hyperparathyroidism [ICD-11: 5A51]
 [44]
Mifepristone
 API Info
Cushing syndrome [ICD-11: 5A70]
 [45]
Omega-3 carboxylic acid
 API Info
Hypertriglyceridaemia [ICD-11: 5C80]
 [46]
Miglitol
 API Info
Diabetic complication [ICD-11: 5A2Y]
 [47]
       ICD Disease Classification 06 Mental/behavioural/neurodevelopmental disorder Click to Show/Hide
Bupropion
 API Info
Nicotine dependence [ICD-11: 6C4A]
 [48]
Alprazolam
 API Info
Anxiety disorder [ICD-11: 6B00]
 [49]
Lamotrigine
 API Info
Bipolar disorder [ICD-11: 6A60]
 [50]
Fluoxetine
 API Info
Major depressive disorder [ICD-11: 6A70]
 [51]
Duloxetine
 API Info
Major depressive disorder [ICD-11: 6A70]
 [52]
Venlafaxine
 API Info
Major depressive disorder [ICD-11: 6A70]
 [53]
Sertraline
 API Info
Major depressive disorder [ICD-11: 6A70]
 [54]
Amitriptyline
 API Info
Major depressive disorder [ICD-11: 6A70]
 [55]
Olanzapine
 API Info
Schizophrenia [ICD-11: 6A20]
 [56]
Hydroxyzine
 API Info
Anxiety disorder [ICD-11: 6B00]
 [57]
Ziprasidone
 API Info
Schizophrenia [ICD-11: 6A20]
 [58]
Paroxetine
 API Info
Major depressive disorder [ICD-11: 6A70]
 [59]
Quetiapine
 API Info
Schizophrenia [ICD-11: 6A20]
 [60]
Cyclobenzaprine
 API Info
Major depressive disorder [ICD-11: 6A70]
 [61]
Mirtazapine
 API Info
Major depressive disorder [ICD-11: 6A70]
 [62]
Imipramine
 API Info
Major depressive disorder [ICD-11: 6A70]
 [63]
Prochlorperazine
 API Info
Schizophrenia [ICD-11: 6A20]
 [64]
Desipramine
 API Info
Attention deficit hyperactivity disorder [ICD-11: 6A05]
 [65]
Fluvoxamine
 API Info
Obsessive-compulsive disorder [ICD-11: 6B20]
 [66]
Fluphenazine
 API Info
Schizophrenia [ICD-11: 6A20]
 [67]
Trazodone
 API Info
Major depressive disorder [ICD-11: 6A70]
 [68]
Escitalopram
 API Info
Major depressive disorder [ICD-11: 6A70]
 [69]
Citalopram
 API Info
Major depressive disorder [ICD-11: 6A70]
 [70]
Protriptyline
 API Info
Major depressive disorder [ICD-11: 6A70]
 [71]
Perphenazine
 API Info
Schizophrenia [ICD-11: 6A20]
 [72]
Naltrexone
 API Info
Alcohol dependence [ICD-11: 6C40]
 [73]
       ICD Disease Classification 07 Sleep-wake disorder Click to Show/Hide
Zolpidem
 API Info
Insomnia [ICD-11: 7A00]
 [74]
Eszopiclone
 API Info
Insomnia [ICD-11: 7A00]
 [75]
       ICD Disease Classification 08 Nervous system disease Click to Show/Hide
Acetaminophen
 API Info
Anaesthesia [ICD-11: 8E22]
 [76]
Morphine
 API Info
Anaesthesia [ICD-11: 8E22]
 [77]
Gabapentin
 API Info
Focal seizure [ICD-11: 8A68]
 [78]
Oxycodone
 API Info
Anaesthesia [ICD-11: 8E22]
 [79]
Valproic acid
 API Info
Epilepsy [ICD-11: 8A60]
 [80]
Ropinirole
 API Info
Parkinsonism [ICD-11: 8A00]
 [81]
Levetiracetam
 API Info
Focal seizure [ICD-11: 8A68]
 [82]
Tramadol
 API Info
Anaesthesia [ICD-11: 8E22]
 [83]
Topiramate
 API Info
Focal seizure [ICD-11: 8A68]
 [84]
Oxymorphone
 API Info
Anaesthesia [ICD-11: 8E22]
 [85]
Galantamine
 API Info
Alzheimer disease [ICD-11: 8A20]
 [86]
Oxcarbazepine
 API Info
Epilepsy [ICD-11: 8A60]
 [87]
Hydromorphone
 API Info
Anaesthesia [ICD-11: 8E22]
 [88]
Hydrocodone
 API Info
Anaesthesia [ICD-11: 8E22]
 [89]
Donepezil
 API Info
Alzheimer disease [ICD-11: 8A20]
 [90]
Tiagabine
 API Info
Epilepsy [ICD-11: 8A60]
 [91]
Zolmitriptan
 API Info
Migraine [ICD-11: 8A80]
 [92]
Entacapone
 API Info
Parkinsonism [ICD-11: 8A00]
 [93]
Sumatriptan
 API Info
Migraine [ICD-11: 8A80]
 [94]
Deutetrabenazine
 API Info
Huntington disease [ICD-11: 8A01]
 [95]
Ticlopidine
 API Info
Cerebral stroke [ICD-11: 8B11]
 [96]
Dimethyl fumarate
 API Info
Multiple sclerosis [ICD-11: 8A40]
 [97]
       ICD Disease Classification 09 Visual system disease Click to Show/Hide
Dextromethorphan
 API Info
Allergic conjunctivitis [ICD-11: 9A60]
 [98]
       ICD Disease Classification 10 Ear/mastoid process disease Click to Show/Hide
Diphenhydramine
 API Info
Meniere disease [ICD-11: AB31]
 [99]
Cephalexin
 API Info
Acute otitis media [ICD-11: AB00]
 [100]
       ICD Disease Classification 11 Circulatory system disease Click to Show/Hide
Diltiazem
 API Info
Essential hypertension [ICD-11: BA00]
 [101]
Aspirin
 API Info
Myocardial infarction [ICD-11: BA41]
 [102]
Metoprolol
 API Info
Essential hypertension [ICD-11: BA00]
 [103]
Verapamil
 API Info
Essential hypertension [ICD-11: BA00]
 [104]
Caffeine
 API Info
Orthostatic hypotension [ICD-11: BA21]
 [105]
Felodipine
 API Info
Essential hypertension [ICD-11: BA00]
 [106]
Amlodipine
 API Info
Angina pectoris [ICD-11: BA40]
 [107]
Propafenone
 API Info
Ventricular tachyarrhythmia [ICD-11: BC71]
 [108]
Benazepril
 API Info
Essential hypertension [ICD-11: BA00]
 [109]
Carvedilol
 API Info
Congestive heart failure [ICD-11: BD10]
 [110]
Spironolactone
 API Info
Congestive heart failure [ICD-11: BD10]
 [111]
Labetalol
 API Info
Essential hypertension [ICD-11: BA00]
 [112]
Isosorbide mononitrate
 API Info
Angina pectoris [ICD-11: BA40]
 [113]
Irbesartan
 API Info
Essential hypertension [ICD-11: BA00]
 [114]
Dipyridamole
 API Info
Atherosclerosis [ICD-11: BA80]
 [115]
Indapamide
 API Info
Essential hypertension [ICD-11: BA00]
 [116]
Nebivolol
 API Info
Pulmonary hypertension [ICD-11: BB01]
 [117]
Betaxolol
 API Info
Essential hypertension [ICD-11: BA00]
 [118]
Eplerenone
 API Info
Ventricular dysfunction [ICD-11: BD13]
 [119]
Methyldopa
 API Info
Essential hypertension [ICD-11: BA00]
 [120]
Bisoprolol
 API Info
Essential hypertension [ICD-11: BA00]
 [121]
Chlorothiazide
 API Info
Congestive heart failure [ICD-11: BD10]
 [122]
Ranolazine
 API Info
Angina pectoris [ICD-11: BA40]
 [123]
Eprosartan
 API Info
Essential hypertension [ICD-11: BA00]
 [124]
Macitentan
 API Info
Pulmonary hypertension [ICD-11: BB01]
 [125]
       ICD Disease Classification 12 Respiratory system disease Click to Show/Hide
Clarithromycin
 API Info
Pneumocystis pneumonia [ICD-11: CA40]
 [126]
Chlorpheniramine
 API Info
Allergic rhinitis [ICD-11: CA08]
 [127]
Fexofenadine
 API Info
Allergic rhinitis [ICD-11: CA08]
 [128]
Loratadine
 API Info
Allergic rhinitis [ICD-11: CA08]
 [129]
Desloratadine
 API Info
Allergic rhinitis [ICD-11: CA08]
 [130]
Budesonide
 API Info
Allergic rhinitis [ICD-11: CA08]
 [131]
Levofloxacin
 API Info
Bronchitis [ICD-11: CA20]
 [132]
Ceftibuten
 API Info
Bronchitis [ICD-11: CA20]
 [133]
Levocetirizine
 API Info
Allergic rhinitis [ICD-11: CA08]
 [134]
Ofloxacin
 API Info
Pneumocystis pneumonia [ICD-11: CA40]
 [135]
       ICD Disease Classification 13 Digestive system disease Click to Show/Hide
Doxycycline
 API Info
Periodontal disease [ICD-11: DA0C]
 [136]
Omeprazole
 API Info
Gastro-oesophageal reflux disease [ICD-11: DA22]
 [137]
Bisacodyl
 API Info
Irritable bowel syndrome [ICD-11: DD91]
 [138]
Pantoprazole
 API Info
Gastro-oesophageal reflux disease [ICD-11: DA22]
 [139]
Meclizine
 API Info
Functional nausea/vomiting [ICD-11: DD90]
 [140]
Lansoprazole
 API Info
Duodenal ulcer [ICD-11: DA63]
 [141]
Ranitidine
 API Info
Gastric ulcer [ICD-11: DA60]
 [142]
Esomeprazole
 API Info
Duodenal ulcer [ICD-11: DA63]
 [143]
Bismuth subsalicylate
 API Info
Irritable bowel syndrome [ICD-11: DD91]
 [144]
Ondansetron
 API Info
Gastritis [ICD-11: DA42]
 [145]
Cimetidine
 API Info
Duodenal ulcer [ICD-11: DA63]
 [146]
Rabeprazole
 API Info
Gastro-oesophageal reflux disease [ICD-11: DA22]
 [147]
Dexlansoprazole
 API Info
Gastro-oesophageal reflux disease [ICD-11: DA22]
 [148]
Alosetron
 API Info
Irritable bowel syndrome [ICD-11: DD91]
 [149]
Dolasetron
 API Info
Functional nausea/vomiting [ICD-11: DD90]
 [150]
Rolapitant
 API Info
Functional nausea/vomiting [ICD-11: DD90]
 [151]
Granisetron
 API Info
Functional nausea/vomiting [ICD-11: DD90]
 [152]
       ICD Disease Classification 14 Skin disease Click to Show/Hide
Pseudoephedrine
 API Info
Erythema multiforme [ICD-11: EB12]
 [153]
Isotretinoin
 API Info
Acne vulgaris [ICD-11: ED80]
 [154]
Demeclocycline
 API Info
Acne vulgaris [ICD-11: ED80]
 [155]
Propantheline
 API Info
Excessive sweating [ICD-11: EE00]
 [156]
Tretinoin
 API Info
Acne vulgaris [ICD-11: ED80]
 [157]
       ICD Disease Classification 15 Musculoskeletal/connective-tissue disease Click to Show/Hide
Naproxen
 API Info
Rheumatoid arthritis [ICD-11: FA20]
 [158]
Indomethacin
 API Info
Rheumatoid arthritis [ICD-11: FA20]
 [159]
Diclofenac
 API Info
Knee osteoarthritis [ICD-11: FA01]
 [160]
Etodolac
 API Info
Rheumatoid arthritis [ICD-11: FA20]
 [161]
Nabumetone
 API Info
Rheumatoid arthritis [ICD-11: FA20]
 [162]
Prednisone
 API Info
Rheumatoid arthritis [ICD-11: FA20]
 [163]
Cyclosporin A
 API Info
Rheumatoid arthritis [ICD-11: FA20]
 [164]
Risedronic acid
 API Info
Paget's disease [ICD-11: FB85]
 [165]
Fenoprofen
 API Info
Rheumatoid arthritis [ICD-11: FA20]
 [166]
Flurbiprofen
 API Info
Rheumatoid arthritis [ICD-11: FA20]
 [167]
Oxaprozin
 API Info
Rheumatoid arthritis [ICD-11: FA20]
 [168]
Raloxifene
 API Info
Osteoporosis [ICD-11: FB83]
 [169]
Leflunomide
 API Info
Rheumatoid arthritis [ICD-11: FA20]
 [170]
       ICD Disease Classification 16 Genitourinary system disease Click to Show/Hide
Ibuprofen
 API Info
Dysmenorrhea [ICD-11: GA34]
 [171]
Finasteride
 API Info
Prostatic hyperplasia [ICD-11: GA90]
 [172]
Oxybutynin
 API Info
Overactive bladder [ICD-11: GC50]
 [173]
Tamsulosin
 API Info
Prostatic hyperplasia [ICD-11: GA90]
 [174]
Dutasteride
 API Info
Prostatic hyperplasia [ICD-11: GA90]
 [175]
Trospium
 API Info
Overactive bladder [ICD-11: GC50]
 [176]
Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
      G-protein coupled receptor (GPCR)
            DBT Name: Adenosine receptor A3 (AA3R) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 9.3 uM (tested by experiment) [177]
                    Tested Species Homo sapiens (Human)
                    UniProt ID AA3R_HUMAN
            DBT Name: Muscarinic receptor M1 (ACM1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 2.6 uM (tested by experiment) [177]
                    Tested Species Homo sapiens (Human)
                    UniProt ID ACM1_HUMAN
            DBT Name: Muscarinic receptor M2 (ACM2) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 1.3 uM (tested by experiment) [177]
                    Tested Species Homo sapiens (Human)
                    UniProt ID ACM2_HUMAN
            DBT Name: Dopamine D3 receptor (DRD3) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 22 uM (tested by experiment) [177]
                    Tested Species Homo sapiens (Human)
                    UniProt ID DRD3_HUMAN
            DBT Name: Histamine H3 receptor (HRH3) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 5.3 uM (tested by experiment) [177]
                    Tested Species Homo sapiens (Human)
                    UniProt ID HRH3_HUMAN
            DBT Name: Thromboxane A2 receptor (TBXA2R) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 12 uM (tested by experiment) [177]
                    Tested Species Homo sapiens (Human)
                    UniProt ID TA2R_HUMAN
      Oxidoreductase (ORase)
            DBT Name: Prostaglandin G/H synthase 1 (COX-1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 1 uM (tested by experiment) [177]
                    Tested Species Homo sapiens (Human)
                    UniProt ID PGH1_HUMAN
            DBT Name: Prostaglandin G/H synthase 2 (COX-2) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 2.9 uM (tested by experiment) [177]
                    Tested Species Homo sapiens (Human)
                    UniProt ID PGH2_HUMAN
            DBT Name: Cytochrome P450 3A (CYP3A) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity Inhibition (tested by experiment) [178]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP3A4_HUMAN ; CP3A5_HUMAN ; CP3A7_HUMAN ; CP343_HUMAN
               Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity Protein expression downregulation (tested by experiment) [179]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP3A4_HUMAN ; CP3A5_HUMAN ; CP3A7_HUMAN ; CP343_HUMAN
            DBT Name: Albendazole monooxygenase (CYP3A4) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 201 uM (tested by experiment) [180]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP3A4_HUMAN
               Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 400 uM (tested by experiment) [181]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP3A4_HUMAN
               Experiment (3) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity Protein expression downregulation (tested by experiment) [182]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP3A4_HUMAN
            DBT Name: Cytochrome P450 2E1 (CYP2E1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 225 uM (tested by experiment) [180]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP2E1_HUMAN
            DBT Name: Cytochrome P450 2C9 (CYP2C9) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity EC50 = 374.2 uM (tested by experiment) [180]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP2C9_HUMAN
               Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 40 uM (tested by experiment) [181]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP2C9_HUMAN
            DBT Name: Mephenytoin 4-hydroxylase (CYP2C19) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 118.6 uM (tested by experiment) [180]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP2CJ_HUMAN
            DBT Name: Debrisoquine 4-hydroxylase (CYP2D6) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity EC50 = 486.4 uM (tested by experiment) [180]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP2D6_HUMAN
            DBT Name: Cytochrome P450 3A5 (CYP3A5) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 186.4 uM (tested by experiment) [180]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP3A5_HUMAN
      Hydrolase (HDase)
            DBT Name: Phosphodiesterase 3A (PDE3A) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 > 3 uM (tested by experiment) [177]
                    Tested Species Homo sapiens (Human)
                    UniProt ID PDE3A_HUMAN
            DBT Name: Phosphodiesterase 4D (PDE4D) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 > 10 uM (tested by experiment) [177]
                    Tested Species Homo sapiens (Human)
                    UniProt ID PDE4D_HUMAN
      Primary active transporter (PAT)
            DBT Name: Multidrug resistance protein 1 (ABCB1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 0.31 mg.mL-1 (tested by experiment) [183]
                    Tested Species Homo sapiens (Human)
                    UniProt ID MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN
               Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity Inhibition ratio = 60 % (tested by experiment) [184]
                    Tested Species Homo sapiens (Human)
                    UniProt ID MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN
               Experiment (3) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity Inhibition ratio > 250 % (tested by experiment) [185]
                    Tested Species Homo sapiens (Human)
                    UniProt ID MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN
      Nuclear receptor (NR)
            DBT Name: Estrogen receptor alpha (ESR1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 > 10 uM (tested by experiment) [177]
                    Tested Species Homo sapiens (Human)
                    UniProt ID ESR1_HUMAN
            DBT Name: Progesterone receptor (PGR) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 21 uM (tested by experiment) [177]
                    Tested Species Homo sapiens (Human)
                    UniProt ID PRGR_HUMAN
      Cell line (CELL)
            DBT Name: Colon cancer Caco-2 cells (Caco-2) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity Chylomicron secretion upregulation (tested by experiment) [186]
                    Tested Species Homo sapiens (Human)
References
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169 FDA label for approved raloxifene from the official website of the U.S. Food and Drug Administration.
170 FDA label for approved leflunomide from the official website of the U.S. Food and Drug Administration.
171 FDA label for approved ibuprofen from the official website of the U.S. Food and Drug Administration.
172 FDA label for approved finasteride from the official website of the U.S. Food and Drug Administration.
173 FDA label for approved oxybutynin from the official website of the U.S. Food and Drug Administration.
174 FDA label for approved tamsulosin from the official website of the U.S. Food and Drug Administration.
175 FDA label for approved dutasteride from the official website of the U.S. Food and Drug Administration.
176 FDA label for approved trospium from the official website of the U.S. Food and Drug Administration.
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179 Scientific perspectives on extending the provision for waivers of in vivo bioavailability and bioequivalence studies for drug products containing high solubility-low permeability drugs (BCS-Class 3). AAPS J. 2008 Jun;10(2):300-5.
180 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
181 Effects of non-ionic surfactants on cytochrome P450-mediated metabolism in vitro. Eur J Pharm Biopharm. 2011 May;78(1):166-72.
182 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
183 Reversal of multidrug resistance by surfactants. Br J Cancer. 1992 Jul;66(1):62-8.
184 A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P-glycoprotein activity in vitro. J Pharm Sci. 2002 Sep;91(9):1991-2002.
185 Effect of excipients on breast cancer resistance protein substrate uptake activity. J Control Release. 2007 Dec 4;124(1-2):1-5.
186 Stimulation of triglyceride-rich lipoprotein secretion by polysorbate 80: in vitro and in vivo correlation using Caco-2 cells and a cannulated rat intestinal lymphatic model. Pharm Res. 2004 Dec;21(12):2320-6.

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