Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0JA5E)
DIG Name
Calcium carbonate
Synonyms    Click to Show/Hide the Synonyms of This DIG
Aragonite; CALCIUM CARBONATE; 471-34-1; Calcite; Chalk; Carbonic acid calcium salt (1:1); Calcium carbonate (1:1); Calofort U; Precipitated calcium carbonate; calciumcarbonate; 1317-65-3; CaCO3; Calciumcarbonat; Kalziumkarbonat; Calcite (Ca(Co3)); Calcium carbonate slurry; kohlensaurer Kalk; UNII-H0G9379FGK; carbonato de calcio; Chalk, Precipitated; carbonate de calcium; calcium trioxidocarbonate; Calcium carbonate [USP]; Carbonate (calcium); Kalkspar; CHEBI:3311; H0G9379FGK; 13397-26-7; Aeromatt; MFCD00010906; Akadama; Albacar; Albafil; Albaglos; Atomite; Calcicoll; Calibrite; Calmote; Calseeds; Calwhite; Carbium; Chemcarb; Clefnon; Duramite; Hydrocarb; Kotamite; Microcarb; Micromya; Neoanticid; Atomit; Calmos; Caltec; Dacote; Marfil; Levigated chalk; Allied whiting; Tums; Marble white; Calcium carbonate (USP); Camel-carb; Camel-wite; Camel-tex; Calcium carbonate-13C; Britomya M; Britomya S; Calofort S; Calofort T; Calopake F; Calopake H; Hakuenka O; Multiflex MM; Multiflex SC; Albaglos SF; Calopake FS; Calopake PC; Carusis P; Garolite SA; Gilder's whiting; Hakuenka CC; Hakuenka DD; Hakuenka PX; Hakuenka PZ; Homocal D; Multifex MM; Neolite F; Calcene CO; Calcene NC; Calcene TM; Carbium MM; Hakuenka CCR; Neolite SP; Crystic prefil S; Neolite TPS; Calcilit 8; Carborex 2; Cal-Sup; Microwhite 25; R Jutan; Calcium Carbonate Nanopowder; Hakuenka T-DD; Brilliant 15; Filtex White Base; Hydrocarb 60; Hydrocarb 65; Marblewhite 325; Cal-Light SA; Calcidar 40; Carbital 90; Durcal 2NH; Non-Fer-Al; CCC G-white; Kredafil RM 5; Brilliant BR 15; Calofil A 4; Calofil B 1; Calofil E 2; C.I. Pigment White 18; Calcilit 100; Hakuenka R 06; Micromic CR 16; Calcium monocarbonate; Durcal 10; Durcal 40; Monocalcium carbonate; Brilliant 1500; Calofor U 50; Calopake high opacity; CCC No.AA oolitic; Eskalon 100; Eskalon 200; Eskalon 400; Eskalon 800; Finncarb 6002; C 50 (carbonate); Kredafil 150 Extra; Albacar 5970; Caswell No. 139; Eskalon 1500; MSK-PO; MSK-C; MSK-G; MSK-K; MSK-P; MSK-V; NCC-P; Slaker rejects; Mylanta soothing lozenges; Natural calcium carbonate; Oyster shell; MC-T; Calcium carbonate, 99%, extra pure; Calcium, Reference Standard Solution; calcium;carbonate; Durcal C 640305; P-Lite 500; P-Lite 700; Di-Gel Tablets; Calcium carbonate, 97%, pure, chunks; Carbonic Acid Calcium Salt; Precipitated chalk; Calcium carbonate, 99+%, ACS reagent; EGRI M 5; Pigment white 18; KULU 40; Calcium carbonate, 99+%, for biochemistry; Calcium carbonate, precipitated; BRT 30; CCRIS 1333; HSDB 927; NCC 45; Calcium carbonate, 98%, pure, light powder; Tylenol Headache Plus; Calcium carbonate, 98+%, pure, heavy powder; BS 32; Vaterite (Ca(CO3)); BRT 1500; Calcium carbonate, 99%, for analysis, precipitated; Calcium carbonate, 99.999%, (trace metal basis); Calcium carbonate, ACS reagent, chelometric standard; Carbonic acid, calcium salt (1:1); EINECS 207-439-9; AX 363; BF 200; KS 500; NS 100; NS 200; NS 400; EPA Pesticide Chemical Code 073502; KS 1300; KS 1500; KS 1800; KS 2100; NS 2500; CI 77220; N 34; N 43; Caltan; Kalk; Chalk Powder; Coral Calcium; Marble Chips; carbonate calcium; C.I. 77220; K 250; Chalk, pure; calcium carb onate; Copper Nickel Foil; Marble, CP; T 130-2500; Cal-sup (TN); CCaO3; calcium(II) carbonate; Calcium carbonate, CP; Calcium Carbonate,(S); Acid controller complete; ACMC-1ADFV; Calcium Carbonate (AS); Calcium carbonate, powder; EC 207-439-9; SCHEMBL3261; Calcium Carbonate Dispersion; Calcium carbonate, technical; Precpitated calcium carbonate; Calcium Carbonate Granular DC; Calcium Carbonate Precipitated; Ca (C O3); Calcium Carbonate Nanoparticles; Calcium Carbonate Microparticles; CHEMBL1200539; DTXSID3036238; INS NO.170(I); NDI 443; Calcium carbonate, ReagentPlus(R); Calcium carbonate,puratronic powder; INS-170(I); Calcium carbonate, AR, >=98.5%; Calcium carbonate, LR, >=98.5%; AKOS015903256; Calcium carbonate, precipitated (JAN); Calcium carbonate, chelometric standard; Children's mylanta upset stomach relief; DB06724; Precipitated calcium carbonate (JP17); Calcium carbonate, BioXtra, >=99.0%; Calcium carbonate, Monocalcium carbonate; 13701-58-1; Calcium carbonate, powder A.C.S. reagent; E-170(I); E170; S266; Calcium carbonate, puriss. p.a., >=99%; Calcium carbonate, USP, 98.0-100.5%; Calcium carbonate, NIST(R) SRM(R) 915b; E 170; FT-0623383; C08129; Calcium carbonate, SAJ first grade, >=98.0%; Calcium carbonate, tested according to Ph.Eur.; D00932; Q23767; Calcium carbonate, 99.999% trace metals basis; Calcium carbonate, JIS special grade, >=99.5%; Calcium carbonate, p.a., 99.0%, ACS reagent; Calcium carbonate, >=99.995% trace metals basis; Calcium carbonate, Vetec(TM) reagent grade, 99%; Calcium carbonate, ACS reagent, >=99.0%, powder; Calcium carbonate, BioUltra, precipitated, >=99.0% (KT); Calcium carbonate, powder, <=30 mum particle size, 98%; Calcium carbonate, primary reference standard, 99.95-100.05%; NBS 18 (carbon isotopes in carbonatite), NIST(R) RM 8543; Calcium Carbonate, Trace metals grade 99.99% trace metals basis; Calcium Carbonate (AS), United States Pharmacopeia (USP) Reference Standard; Calcium carbonate, BioReagent, suitable for insect cell culture, >=99.0%; Calcium, Ion chromatography standard solution, Specpure?, Ca2+ 1000?g/ml; Calcium carbonate, ACS reagent, chelometric standard, 99.95-100.05% dry basis; Calcium carbonate, anhydrous, free-flowing, Redi-Dri(TM), ACS reagent, >=99%; Calcium carbonate, anhydrous, free-flowing, Redi-Dri(TM), ReagentPlus(R), >=99%; Calcium carbonate, Pharmaceutical Secondary Standard; Certified Reference Material; Calcium carbonate, certified reference material for titrimetry, certified by BAM, according to ISO 17025, >=99.5%; Calcium carbonate, puriss., meets analytical specification of Ph. Eur., BP, USP, FCC, E170, precipitated, 98.5-100.5% (based on anhydrous substance)
DIG Function
Binding agent; Buffering agent; Diluent; Opacifying agent
PubChem CID
10112
Formula
CCaO3
Canonical SMILES
C(=O)([O-])[O-].[Ca+2]
InChI
1S/CH2O3.Ca/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2
InChIKey
VTYYLEPIZMXCLO-UHFFFAOYSA-L
   Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=10112"></iframe>
3D MOL is not available 2D MOL
Physicochemical Properties Molecular Weight 100.09 Topological Polar Surface Area 63.2
XlogP N.A. Complexity 18.8
Heavy Atom Count 5 Rotatable Bond Count 0
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 3
Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
       ICD Disease Classification 01 Infectious/parasitic disease Click to Show/Hide
Didanosine
 API Info
Human immunodeficiency virus infection [ICD-11: 1C60]
 [1]
Entecavir
 API Info
Viral hepatitis [ICD-11: 1E51]
 [2]
       ICD Disease Classification 05 Endocrine/nutritional/metabolic disease Click to Show/Hide
Atorvastatin
 API Info
Hyperlipidaemia [ICD-11: 5C8Z]
 [3]
Glyburide
 API Info
Diabetes mellitus [ICD-11: 5A10]
 [4]
Fluvastatin
 API Info
Hypertriglyceridaemia [ICD-11: 5C80]
 [5]
Chlorpropamide
 API Info
Diabetes mellitus [ICD-11: 5A10]
 [6]
       ICD Disease Classification 06 Mental/behavioural/neurodevelopmental disorder Click to Show/Hide
Risperidone
 API Info
Schizophrenia [ICD-11: 6A20]
 [7]
Lamotrigine
 API Info
Bipolar disorder [ICD-11: 6A60]
 [8]
Desipramine
 API Info
Attention deficit hyperactivity disorder [ICD-11: 6A05]
 [9]
Perphenazine
 API Info
Schizophrenia [ICD-11: 6A20]
 [10]
       ICD Disease Classification 08 Nervous system disease Click to Show/Hide
Acetaminophen
 API Info
Anaesthesia [ICD-11: 8E22]
 [11]
Gabapentin
 API Info
Focal seizure [ICD-11: 8A68]
 [12]
       ICD Disease Classification 11 Circulatory system disease Click to Show/Hide
Aspirin
 API Info
Myocardial infarction [ICD-11: BA41]
 [13]
Caffeine
 API Info
Orthostatic hypotension [ICD-11: BA21]
 [14]
       ICD Disease Classification 13 Digestive system disease Click to Show/Hide
Bisacodyl
 API Info
Irritable bowel syndrome [ICD-11: DD91]
 [15]
Pantoprazole
 API Info
Gastro-oesophageal reflux disease [ICD-11: DA22]
 [16]
Simethicone
 API Info
Irritable bowel syndrome [ICD-11: DD91]
 [17]
Esomeprazole
 API Info
Duodenal ulcer [ICD-11: DA63]
 [18]
Bismuth subsalicylate
 API Info
Irritable bowel syndrome [ICD-11: DD91]
 [19]
       ICD Disease Classification 14 Skin disease Click to Show/Hide
Propantheline
 API Info
Excessive sweating [ICD-11: EE00]
 [20]
       ICD Disease Classification 15 Musculoskeletal/connective-tissue disease Click to Show/Hide
Metaxalone
 API Info
Myalgia [ICD-11: FB56]
 [21]
       ICD Disease Classification 16 Genitourinary system disease Click to Show/Hide
Ibuprofen
 API Info
Dysmenorrhea [ICD-11: GA34]
 [22]
Trospium
 API Info
Overactive bladder [ICD-11: GC50]
 [23]
       ICD Disease Classification 17 Sexual health-related condition Click to Show/Hide
Avanafil
 API Info
Erectile dysfunction [ICD-11: HA01]
 [24]
Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
      Lyase/isomerase/ligase (L/I/G)
            DBT Name: Carbonic anhydrase IX (CA9) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity Ki = 8600 nM (estimated based on the structural similarity with CHEMBL1161632 ) [25]
                    Structural Similarity Tanimoto coefficient = 1
                    Tested Species Homo sapiens (Human)
                    UniProt ID CAH9_HUMAN
            DBT Name: Carbonic anhydrase VII (CA7) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity Ki = 160000 nM (estimated based on the structural similarity with CHEMBL1161632 ) [26]
                    Structural Similarity Tanimoto coefficient = 1
                    Tested Species Homo sapiens (Human)
                    UniProt ID CAH7_HUMAN
References
1 FDA label for approved didanosine from the official website of the U.S. Food and Drug Administration.
2 FDA label for approved entecavir from the official website of the U.S. Food and Drug Administration.
3 FDA label for approved atorvastatin from the official website of the U.S. Food and Drug Administration.
4 FDA label for approved glyburide from the official website of the U.S. Food and Drug Administration.
5 FDA label for approved fluvastatin from the official website of the U.S. Food and Drug Administration.
6 FDA label for approved chlorpropamide from the official website of the U.S. Food and Drug Administration.
7 FDA label for approved risperidone from the official website of the U.S. Food and Drug Administration.
8 FDA label for approved lamotrigine from the official website of the U.S. Food and Drug Administration.
9 FDA label for approved desipramine from the official website of the U.S. Food and Drug Administration.
10 FDA label for approved perphenazine from the official website of the U.S. Food and Drug Administration.
11 FDA label for approved acetaminophen from the official website of the U.S. Food and Drug Administration.
12 FDA label for approved gabapentin from the official website of the U.S. Food and Drug Administration.
13 FDA label for approved aspirin from the official website of the U.S. Food and Drug Administration.
14 FDA label for approved caffeine from the official website of the U.S. Food and Drug Administration.
15 FDA label for approved bisacodyl from the official website of the U.S. Food and Drug Administration.
16 FDA label for approved pantoprazole from the official website of the U.S. Food and Drug Administration.
17 FDA label for approved simethicone from the official website of the U.S. Food and Drug Administration.
18 FDA label for approved esomeprazole from the official website of the U.S. Food and Drug Administration.
19 Bismuth Subsalicylate.
20 Propantheline bromide in the management of hyperhidrosis associated with spinal cord injury. Ann Pharmacother. 1995 May;29(5):489-92.
21 FDA label for approved metaxalone from the official website of the U.S. Food and Drug Administration.
22 FDA label for approved ibuprofen from the official website of the U.S. Food and Drug Administration.
23 FDA label for approved trospium from the official website of the U.S. Food and Drug Administration.
24 FDA label for approved avanafil from the official website of the U.S. Food and Drug Administration.
25 Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):567-71.
26 Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions. Bioorg Med Chem Lett. 2006 Jun 15; 16(12):3139-43.

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