Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00313)
Name
Hydrocodone
Synonyms    Click to Show/Hide the Synonyms of This API
HYDROCODONE; Dihydrocodeinone; Hydrocodon; Hydrocone; Hydroconum; Codinovo; Dicodid; Bekadid; Idrocodone; Idrocodone [DCIT]; (-)-Dihydrocodeinone; hidrocodona; Hydrocodonum; Hydrocodonum [INN-Latin]; 125-29-1; Hidrocodona [INN-Spanish]; Multacodin; Codeinone, dihydro-; UNII-6YKS4Y3WQ7; 4,5-alpha-Epoxy-3-methoxy-17-methylmorphinan-6-one; 6-Oxo-3-methoxy-N-methyl-4,5-epoxymorphinan; 4,5alpha-Epoxy-3-methoxy-17-methylmorphinan-6-one; 6YKS4Y3WQ7; Zohydro; CHEBI:5779; NSC 19044; Hydrocodone [INN:BAN]; (4R,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one; Hydrocodone polistirex; 50678-79-0; Hydrocodone (INN); HSDB 3097; NCGC00159317-02; EINECS 204-733-9; 4,5.alpha.-Epoxy-3-methoxy-17-methylmorphinan-6-one; BRN 0094193; opioid1; DEA No. 9193; SCHEMBL2987; CHEMBL1457; 4-27-00-03580 (Beilstein Handbook Reference); 3-methoxy-17-methyl-4,5alpha-epoxymorphinan-6-one; Hydrocodone polistirex [USAN]; GTPL7081; DTXSID8023131; Morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl-; (5alpha)-17-methyl-3-(methyloxy)-4,5-epoxymorphinan-6-one; Hydrocodone 0.1 mg/ml in Methanol; Hydrocodone 1.0 mg/ml in Methanol; NSC19044; ZINC1280665; BDBM50386689; NSC-19044; DB00956; NCGC00159317-03; C08024; D08045; Q411441; 17-methyl-4,5alpha-epoxy-3-methoxymorphinan-6-one; 4,5alpha-epoxy-3-methoxy-17-methyl-morphinan-6-one; Morphinan-6-one,5.alpha.-epoxy-3-methoxy-17-methyl-; Morphinan-6-one, 4,5alpha-epoxy-3-methoxy-17-methyl- (8CI); Morphinan-6-one,5-epoxy-3-methoxy-17-methyl-, (5.alpha.)-; WLN: T B6566 B6/CO 4ABBC R BX FV HO PN GHT&&TTJ JO1 P1; Morphinan-6-one, 4,5-epoxy-3-methoxy-17-methyl-, (5alpha)- (9CI); 4aH-8,5-bcd]furan-5-(6H)-one, 7,7a,8,9-tetrahydro-3-methoxy-12-methyl-; (1S,5R,13R,17R)-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-one
Clinical Status
Approved
Disease Indication Anaesthesia ICD-11: 8E22 [1]
PubChem CID
5284569
Formula
C18H21NO3
Canonical SMILES
CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3C(=O)CC4
InChI
1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3,6,11-12,17H,4-5,7-9H2,1-2H3/t11-,12+,17-,18-/m0/s1
InChIKey
LLPOLZWFYMWNKH-CMKMFDCUSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5284569"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 299.4 Topological Polar Surface Area 38.8
XlogP 2.2 Complexity 509
Heavy Atom Count 22 Rotatable Bond Count 1
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 4
Full List of Drug Formulations (DFMs) Containing This API
          Hydrocodone 20 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butylated hydroxytoluene; Cochineal; Fd&c blue no. 2; Magnesium stearate; Ferric oxide yellow; Talc; Titanium dioxide; Polyethylene glycol 3350; Polysorbate 80; Polyvinyl alcohol; Aluminum oxide; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Polyethylene glycols
                   Dosage Form Abuse-Deterrent 24 HR Extended Release Oral Tablet
                   Company Purdue Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [2]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Caprylic acid DIG Info GPCR84 receptor (Ki = 19600 nM) [4]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [3]
Polyvinyl alcohol DIG Info Debrisoquine 4-hydroxylase (EC50 = 354.8 uM) [5]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
Polyethylene glycol 3350 DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
          Hydrocodone 100 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butylated hydroxytoluene; Fd&c blue no. 2; Magnesium stearate; Talc; Titanium dioxide; Polyethylene glycol 3350; Polysorbate 80; Polyvinyl alcohol; Aluminum oxide; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Polyethylene glycols
                   Dosage Form Abuse-Deterrent 24 HR Extended Release Oral Tablet
                   Company Purdue Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [2]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [3]
Polyvinyl alcohol DIG Info Debrisoquine 4-hydroxylase (EC50 = 354.8 uM) [5]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
Polyethylene glycol 3350 DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
          Hydrocodone 40 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butylated hydroxytoluene; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Talc; Titanium dioxide; Polyethylene glycol 3350; Polysorbate 80; Polyvinyl alcohol; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Polyethylene glycols
                   Dosage Form Abuse-Deterrent 24 HR Extended Release Oral Tablet
                   Company Purdue Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [2]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [3]
Polyvinyl alcohol DIG Info Debrisoquine 4-hydroxylase (EC50 = 354.8 uM) [5]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
Polyethylene glycol 3350 DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
          Hydrocodone 60 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butylated hydroxytoluene; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Talc; Titanium dioxide; Polyethylene glycol 3350; Polysorbate 80; Polyvinyl alcohol; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Polyethylene glycols
                   Dosage Form Abuse-Deterrent 24 HR Extended Release Oral Tablet
                   Company Purdue Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [2]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [3]
Polyvinyl alcohol DIG Info Debrisoquine 4-hydroxylase (EC50 = 354.8 uM) [5]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
Polyethylene glycol 3350 DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
          Hydrocodone 30 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butylated hydroxytoluene; Magnesium stearate; Ferric oxide yellow; Talc; Titanium dioxide; Polyethylene glycol 3350; Polysorbate 80; Polyvinyl alcohol; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Polyethylene glycols
                   Dosage Form Abuse-Deterrent 24 HR Extended Release Oral Tablet
                   Company Purdue Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [2]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [3]
Polyvinyl alcohol DIG Info Debrisoquine 4-hydroxylase (EC50 = 354.8 uM) [5]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
Polyethylene glycol 3350 DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
          Hydrocodone 80 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butylated hydroxytoluene; Magnesium stearate; Ferric oxide red; Talc; Titanium dioxide; Polyethylene glycol 3350; Polysorbate 80; Polyvinyl alcohol; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Polyethylene glycols
                   Dosage Form Abuse-Deterrent 24 HR Extended Release Oral Tablet
                   Company Purdue Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [2]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [3]
Polyvinyl alcohol DIG Info Debrisoquine 4-hydroxylase (EC50 = 354.8 uM) [5]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
Polyethylene glycol 3350 DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
          Hydrocodone 120 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butylated hydroxytoluene; Magnesium stearate; Talc; Titanium dioxide; Polyethylene glycol 3350; Polysorbate 80; Polyvinyl alcohol; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Polyethylene glycols
                   Dosage Form Abuse-Deterrent 24 HR Extended Release Oral Tablet
                   Company Purdue Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [2]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [3]
Polyvinyl alcohol DIG Info Debrisoquine 4-hydroxylase (EC50 = 354.8 uM) [5]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
Polyethylene glycol 3350 DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
          Hydrocodone 10 mg capsule Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Sucrose; Talc; Titanium dioxide; Fd&c red no. 3; Silicon dioxide; Ammonio methacrylate copolymer type b; Gelatin; Hypromelloses; Starch, corn
                   Dosage Form 12 HR Extended Release Oral Capsule
                   Company Zogenix
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [7]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [7]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Sucrose; Talc; Titanium dioxide; Fd&c red no. 3; Silicon dioxide; Ammonio methacrylate copolymer type b; Gelatin; Hypromelloses; Polyethylene glycols; Povidones
                   Dosage Form 12 HR Extended Release Oral Capsule
                   Company Zogenix
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [7]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [7]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Sucrose; Talc; Titanium dioxide; Fd&c red no. 3; Silicon dioxide; Ammonio methacrylate copolymer type b; Gelatin, unspecified; Hypromellose, unspecified; Polyethylene glycol, unspecified; Povidone, unspecified
                   Dosage Form 12 HR Extended Release Oral Capsule
                   Company Pernix Therapeutics
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [7]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [7]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
          Hydrocodone 15 mg capsule Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Sucrose; Talc; Titanium dioxide; Fd&c red no. 3; Silicon dioxide; Ammonio methacrylate copolymer type b; Gelatin; Hypromelloses; Starch, corn
                   Dosage Form 12 HR Extended Release Oral Capsule
                   Company Zogenix
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [7]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [7]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Sucrose; Talc; Titanium dioxide; Fd&c red no. 3; Silicon dioxide; Ammonio methacrylate copolymer type b; Gelatin; Hypromelloses; Polyethylene glycols; Povidones
                   Dosage Form 12 HR Extended Release Oral Capsule
                   Company Zogenix
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [7]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [7]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Sucrose; Talc; Titanium dioxide; Fd&c red no. 3; Silicon dioxide; Ammonio methacrylate copolymer type b; Gelatin, unspecified; Hypromellose, unspecified; Polyethylene glycol, unspecified; Povidone, unspecified
                   Dosage Form 12 HR Extended Release Oral Capsule
                   Company Pernix Therapeutics
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [7]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [7]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
          Hydrocodone 20 mg capsule Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Sucrose; Talc; Titanium dioxide; Fd&c red no. 3; Silicon dioxide; Ammonio methacrylate copolymer type b; Gelatin; Hypromelloses; Starch, corn
                   Dosage Form 12 HR Extended Release Oral Capsule
                   Company Zogenix
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [7]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [7]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Sucrose; Talc; Titanium dioxide; Fd&c red no. 3; Silicon dioxide; Ammonio methacrylate copolymer type b; Gelatin; Hypromelloses; Polyethylene glycols; Povidones
                   Dosage Form 12 HR Extended Release Oral Capsule
                   Company Zogenix
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [7]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [7]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Sucrose; Talc; Titanium dioxide; Fd&c red no. 3; Silicon dioxide; Ammonio methacrylate copolymer type b; Gelatin, unspecified; Hypromellose, unspecified; Polyethylene glycol, unspecified; Povidone, unspecified
                   Dosage Form 12 HR Extended Release Oral Capsule
                   Company Pernix Therapeutics
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [7]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [7]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
          Hydrocodone 30 mg capsule Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Sucrose; Talc; Titanium dioxide; Fd&c red no. 3; Silicon dioxide; Ammonio methacrylate copolymer type b; Gelatin; Hypromelloses; Starch, corn
                   Dosage Form 12 HR Extended Release Oral Capsule
                   Company Zogenix
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [7]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [7]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Sucrose; Talc; Titanium dioxide; Fd&c red no. 3; Silicon dioxide; Ammonio methacrylate copolymer type b; Gelatin; Hypromelloses; Polyethylene glycols; Povidones
                   Dosage Form 12 HR Extended Release Oral Capsule
                   Company Zogenix
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [7]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [7]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Sucrose; Talc; Titanium dioxide; Fd&c red no. 3; Silicon dioxide; Ammonio methacrylate copolymer type b; Gelatin, unspecified; Hypromellose, unspecified; Polyethylene glycol, unspecified; Povidone, unspecified
                   Dosage Form 12 HR Extended Release Oral Capsule
                   Company Pernix Therapeutics
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [7]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [7]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
          Hydrocodone 40 mg capsule Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Sucrose; Talc; Titanium dioxide; Fd&c red no. 3; Silicon dioxide; Ammonio methacrylate copolymer type b; Gelatin; Hypromelloses; Starch, corn
                   Dosage Form 12 HR Extended Release Oral Capsule
                   Company Zogenix
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [7]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [7]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Sucrose; Talc; Titanium dioxide; Fd&c red no. 3; Silicon dioxide; Ammonio methacrylate copolymer type b; Gelatin; Hypromelloses; Polyethylene glycols; Povidones
                   Dosage Form 12 HR Extended Release Oral Capsule
                   Company Zogenix
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [7]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [7]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Sucrose; Talc; Titanium dioxide; Fd&c red no. 3; Silicon dioxide; Ammonio methacrylate copolymer type b; Gelatin, unspecified; Hypromellose, unspecified; Polyethylene glycol, unspecified; Povidone, unspecified
                   Dosage Form 12 HR Extended Release Oral Capsule
                   Company Pernix Therapeutics
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [7]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [7]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
          Hydrocodone 50 mg capsule Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Sucrose; Talc; Titanium dioxide; Fd&c red no. 3; Silicon dioxide; Ammonio methacrylate copolymer type b; Gelatin; Hypromelloses; Starch, corn
                   Dosage Form 12 HR Extended Release Oral Capsule
                   Company Zogenix
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [7]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [7]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Sucrose; Talc; Titanium dioxide; Fd&c red no. 3; Silicon dioxide; Ammonio methacrylate copolymer type b; Gelatin; Hypromelloses; Polyethylene glycols; Povidones
                   Dosage Form 12 HR Extended Release Oral Capsule
                   Company Zogenix
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [7]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [7]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Sucrose; Talc; Titanium dioxide; Fd&c red no. 3; Silicon dioxide; Ammonio methacrylate copolymer type b; Gelatin, unspecified; Hypromellose, unspecified; Polyethylene glycol, unspecified; Povidone, unspecified
                   Dosage Form 12 HR Extended Release Oral Capsule
                   Company Pernix Therapeutics
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [7]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [7]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
References
1 FDA label for approved hydrocodone from the official website of the U.S. Food and Drug Administration.
2 Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. Bioorg Med Chem. 2009 Apr 15; 17(8):3207-11.
3 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
4 An Agonist Radioligand for the Proinflammatory Lipid-Activated G Protein-Coupled Receptor GPR84 Providing Structural Insights. J Med Chem. 2020 Mar 12; 63(5):2391-2410.
5 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
6 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
7 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.